3. Spinal muscular atrophy Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 297 / Drugs : 143 - (DrugBank : 32) / Drug target genes : 54 - Drug target pathways : 82
Spinal muscular atrophy and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 3 | Spinal muscular atrophy | - |
| 13 | Multiple sclerosis | 45.983 |
| 6 | Parkinson disease | 41.411 |
| 2 | Amyotrophic lateral sclerosis | 38.440 |
| 5 | Progressive supranuclear palsy | 37.572 |
| 206 | Fragile X syndrome | 28.157 |
| 18 | Spinocerebellar degeneration | 26.997 |
| 17 | Multiple system atrophy | 24.672 |
| 97 | Ulcerative colitis | 23.421 |
| 156 | Rett syndrome | 23.313 |
| 8 | Huntington disease | 22.881 |
| 205 | Fragile X syndrome related disease | 20.456 |
| 193 | Prader-Willi syndrome | 19.507 |
| 140 | Dorabe syndrome | 18.671 |
| 144 | Lennox-Gastaut syndrome | 18.531 |
| 46 | Malignant rheumatoid arthritis | 17.926 |
| 70 | Spinal stenosis | 16.795 |
| 21 | Mitochondrial disease | 16.352 |
| 152 | PCDH19 related syndrome | 16.000 |
| 96 | Crohn disease | 15.883 |
| 34 | Neurofibromatosis | 15.588 |
| 22 | Moyamoya disease | 15.082 |
| 158 | Tuberous sclerosis | 14.663 |
| 145 | West syndrome | 14.038 |
| 203 | 22q11.2 deletion syndrome | 14.000 |
| 231 | Alpha-1-antitrypsin deficiency | 13.428 |
| 201 | Angelman syndrome | 12.954 |
| 296 | Biliary atresia | 11.958 |
| 272 | Fibrodysplasia ossificans progressiva | 11.704 |
| 298 | Hereditary pancreatitis | 11.181 |
| 155 | Acquired aphasia with convulsive disorder | 10.993 |
| 98 | Eosinophilic gastro-intestinal disorder | 10.241 |
| 75 | Cushing disease | 9.564 |
| 36 | Epidermolysis bullosa | 8.477 |
| 127 | Frontotemporal lobar degeneration | 8.278 |
| 84 | Sarcoidosis | 7.847 |
| 102 | Rubinstein-Taybi syndrome | 7.000 |
| 85 | Idiopathic interstitial pneumonia | 6.635 |
| 256 | Muscle glycogenosis | 5.376 |
| 215 | Tetralogy of Fallot | 5.264 |
| 4 | Primary lateral sclerosis | 5.068 |
| 12 | Congenital myasthenic syndrome | 5.000 |
| 233 | Wolfram syndrome | 4.791 |
| 65 | Primary immunodeficiency | 4.606 |
| 113 | Muscular dystrophy | 4.605 |
| 78 | Hypopituitarism | 4.462 |
| 89 | Lymphangioleiomyomatosis | 4.019 |
| 222 | Primary nephrotic syndrome | 3.217 |
| 49 | Systemic lupus erythematosus | 3.124 |
| 11 | Myasthenia gravis | 3.023 |
| 331 | Idiopathic multicentric castleman disease | 2.960 |
| 26 | HTLV-1-associated myelopathy | 2.638 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 2.358 |
| 90 | Retinitis pigmentosa | 2.317 |
| 251 | Urea cycle disorder | 2.292 |
| 86 | Pulmonary arterial hypertension | 2.201 |
| 337 | Homocystinuria | 2.000 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 1.585 |
| 1 | Spinal and bulbar muscular atrophy | 1.019 |
| 299 | Cystic fibrosis | 1.012 |
| 111 | Congenital myopathy | 1.000 |
| 191 | Werner syndrome | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |