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DR info

Clinical trials : 1,348 / Drugs : 828 - (DrugBank : 133) / Drug target genes : 82 - Drug target pathways : 197

Pulmonary arterial hypertension and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
86	Pulmonary arterial hypertension	-
13	Multiple sclerosis/Neuromyelitis optica	53.159
6	Parkinson disease	38.700
2	Amyotrophic lateral sclerosis	23.588
225	Congenital nephrogenic diabetes insipidus	23.435
46	Malignant rheumatoid arthritis	23.170
51	Scleroderma	22.363
114	Non-dystrophic myotonia syndrome	18.000
85	Idiopathic interstitial pneumonia	17.274
90	Retinitis pigmentosa	16.969
230	Alveolar hypoventilation syndrome	16.216
96	Crohn disease	16.101
58	Hypertrophic cardiomyopathy	16.016
67	Polycystic kidney disease	16.009
299	Cystic fibrosis	15.562
97	Ulcerative colitis	14.247
113	Muscular dystrophy	14.195
115	Hereditary periodic paralysis	13.000
154	Epilepsy with continuous spikes and waves during slow sleep	13.000
226	Interstitial cystitis with Hunners ulcer	12.600
89	Lymphangioleiomyomatosis	11.774
88	Chronic thromboembolic pulmonary hypertension	11.188
127	Frontotemporal lobar degeneration	10.920
34	Neurofibromatosis	10.792
28	Systemic amyloidosis	10.560
70	Spinal stenosis	10.560
81	Congenital adrenal hyperplasia	10.184
8	Huntington disease	10.139
49	Systemic lupus erythematosus	9.600
65	Primary immunodeficiency	8.281
210	Single Ventricle	8.227
222	Primary nephrotic syndrome	7.595
298	Hereditary pancreatitis	7.416
156	Rett syndrome	7.408
256	Muscle glycogenosis	7.397
84	Sarcoidosis	7.176
155	Acquired aphasia with convulsive disorder	6.760
5	Progressive supranuclear palsy	6.580
167	Marfan syndrome	6.528
53	Sjogren syndrome	6.470
19	Lysosomal storage disease	6.366
140	Dorabe syndrome	6.234
17	Multiple system atrophy	6.085
107	Juvenile idiopathic arthritis	5.928
168	Ehlers-Danlos syndrome	5.553
57	Idiopathic dilated cardiomyopathy	5.553
98	Eosinophilic gastro-intestinal disorder	5.276
193	Prader-Willi syndrome	5.265
1	Spinal and bulbar muscular atrophy	5.047
211	Hypoplastic left heart syndrome	5.000
74	Prolactin secreting pituitary adenoma	4.320
66	IgA nephropathy	4.287
218	Alport syndrome	4.208
83	Addison disease	4.208
35	Pemphigus	4.160
144	Lennox-Gastaut syndrome	4.026
227	Osler disease	4.015
87	Pulmonary veno-occlusive disease	4.000
215	Tetralogy of Fallot	3.911
280	Huge arteriovenous malformation with cervicofacial or limb lesion	3.745
254	Porphyria	3.739
296	Biliary atresia	3.603
11	Myasthenia gravis	3.603
10	Charcot-Marie-Tooth disease	3.436
15	Inclusion body myositis	3.436
285	Fanconi anemia	3.267
278	Huge lymphatic malformation with cervicofacial lesion	3.232
206	Fragile X syndrome	3.204
271	Ankylosing spondylitis	3.195
331	Idiopathic multicentric castleman disease	3.188
288	Autoimmune acquired coagulation factor deficiency	3.022
75	Cushing disease	2.947
231	Alpha-1-antitrypsin deficiency	2.916
169	Menkes disease	2.889
170	Occipital horn syndrome	2.889
50	Dermatomyositis	2.875
36	Epidermolysis bullosa	2.837
26	HTLV-1-associated myelopathy	2.750
38	Stevens-Johnson syndrome	2.616
300	IgG4-related disease	2.616
78	Hypopituitarism	2.485
41	Giant cell arteritis	2.424
233	Wolfram syndrome	2.409
149	Hemiconvulsion hemiplegia epilepsy syndrome	2.351
158	Tuberous sclerosis	2.322
251	Urea cycle disorder	2.272
309	Progressive myoclonus epilepsy	2.272
71	Idiopathic osteonecrosis of the femoral head	2.272
3	Spinal muscular atrophy	2.201
22	Moyamoya disease	2.118
118	Myelomeningocele	2.080
77	Growth hormone secreting pituitary adenoma	2.000
337	Homocystinuria	2.000
257	Hepatic glycogenosis	2.000
282	Congenital dyserythropoietic anemia	2.000
63	Idiopathic thrombocytopenic purpura	1.948
228	Bronchiolitis obliterans	1.871
301	Macular dystrophy	1.867
157	Sturge-Weber syndrome	1.836
166	Pseudoxanthoma elasticum	1.836
294	Congenital diaphragmatic hernia	1.836
224	Purpura nephritis	1.833
64	Thrombotic thrombocytopenic purpura	1.734
265	Lipodystrophy	1.662
60	Aplastic anemia	1.575
76	Pituitary gonadotropin secretion hyperthyroidism	1.545
47	Buerger disease	1.545
94	Primary sclerosing cholangitis	1.500
162	Pemphigoid	1.385
164	Oculocutaneous albinism	1.355
310	Congenital anomalies syndrome	1.347
229	Autoimmune pulmonary alveolar proteinosis	1.347
102	Rubinstein-Taybi syndrome	1.337
284	Diamond-Blackfan anemia	1.330
20	Adrenoleukodystrophy	1.330
56	Behcet disease	1.300
43	Microscopic polyangiitis	1.257
61	Autoimmune hemolytic anemia	1.200
212	Tricuspid atresia	1.181
272	Fibrodysplasia ossificans progressiva	1.163
21	Mitochondrial disease	1.080
7	Corticobasal degeneration	1.060
179	Williams syndrome	1.060
106	Cryopyrin-associated periodic syndrome	1.020
91	Budd-Chiari syndrome	1.020
283	Acquired pure red cell aplasia	1.013
137	Focal cortical dysplasia	1.000
192	Cockayne syndrome	1.000
277	Lymphangiomatosis	1.000
281	Klippel-Trenaunay-Weber syndrome	1.000
111	Congenital myopathy	1.000
54	Adult still disease	1.000
52	Mixed connective tissue disease	1.000
220	Rapidly progressive glomerulonephritis	1.000
30	Distal myopathy	1.000