Drug Description in Trials / DrugBank / KEGG DRUG

  

Search results

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 2,2-bis(4-hydroxy-3-tert-butylphenyl)propane [0] ---[5] 19, 86, 90, 276, 299 💬
2 2-(aminomethyl)phenol [1] 2-hoba---[2] 46, 86 💬
3 Acetaminophen [2] Acetaminophen; Paracetamol[1] Acetaminophen 💬 [2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[18] 3, 6, 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
4 Acetic acid C-11 [1] 11C-acetate---[3] 13, 86, 88 💬
5 Acetylsalicylic acid [2] Acetylsalicylic acid; Aspirin[1] Aspirin 💬 [2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 13, 22, 34, 46, 49, 51, 64, 86, 96, 97, 113, 158, 210, 231, 271 💬
6 Activated charcoal [2] Activated charcoal; Carbon[1] Charcoal, activated 💬 --[11] 6, 13, 51, 62, 85, 86, 97, 149, 158, 235, 298 💬
7 Albuterol [2] Albuterol; Salbutamol[2] Albuterol sulfate ,
Albuterol 💬 		[1] ADRB2 💬 [11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[16] 2, 3, 11, 12, 13, 85, 86, 89, 111, 113, 228, 231, 256, 273, 299, 340 💬
8 Alunacedase alfa [0] ---[1] 86 💬
9 Ambrisentan [1] Ambrisentan[1] Ambrisentan 💬 [1] EDNRA 💬 [7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[8] 51, 66, 84, 85, 86, 88, 210, 211 💬
10 Aminohippuric acid [1] Aminohippurate[2] Aminohippurate sodium ,
Aminohippuric acid 💬 		--[2] 67, 86 💬
11 Anakinra [1] Anakinra[1] Anakinra 💬 [2] IL1R1,
IL1R2 💬 		[15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[19] 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
12 Anastrozole [1] Anastrozole[1] Anastrozole 💬 [1] CYP19A 💬 [2] Ovarian steroidogenesis, Steroid hormone biosynthesis 💬[3] 78, 86, 193 💬
13 Apabetalone [1] Apabetalone[1] Apabetalone 💬 --[1] 86 💬
14 Apelin [1] Apelin---[1] 86 💬
15 Artesunate [1] Artesunate[1] Artesunate 💬 --[5] 18, 66, 85, 86, 96 💬
16 AV-101 [1] AV-101---[2] 6, 86 💬
17 Aviptadil [1] Aviptadil[1] Aviptadil 💬 --[4] 49, 51, 84, 86 💬
18 Bardoxolone [0] [1] Bardoxolone 💬 --[7] 66, 67, 84, 85, 86, 218, 222 💬
19 Bardoxolone methyl [1] Bardoxolone methyl[1] Bardoxolone methyl 💬 --[7] 66, 67, 84, 85, 86, 218, 222 💬
20 Benzbromarone [1] Benzbromarone[1] Benzbromarone 💬 --[1] 86 💬
21 Beraprost [2] Beraprost; Beraprost sodium[2] Beraprost sodium ,
Beraprost 💬 		[1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
22 BIA [1] BIA---[3] 6, 86, 299 💬
23 Bisoprolol [2] Bisoprolol; Bisoprolol fumarate[2] Bisoprolol fumarate ,
Bisoprolol 💬 		[1] ADRB1 💬 [13] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 58, 67, 86, 113 💬
24 Bosentan [2] Bosentan; Bosentan monohydrate[2] Bosentan ,
Bosentan 💬 		[2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[11] 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
25 Calcifediol [1] Calcifediol[1] Calcifediol 💬 [1] VDR 💬 [5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[2] 86, 113 💬
26 Capsaicin [1] Capsaicin[1] Capsaicin 💬 [1] TRPV1 💬 [2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[4] 2, 6, 86, 226 💬
27 Captopril [1] Captopril[1] Captopril 💬 [1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 17, 46, 86, 96, 97, 107, 271 💬
28 Carbon monoxide [1] Carbon monoxide[1] Carbon monoxide 💬 --[4] 13, 85, 86, 298 💬
29 Carvedilol [1] Carvedilol[2] Carvedilol ,
Carvedilol phosphate 💬 		[5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬 		[15] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 6, 46, 57, 86, 113, 210 💬
30 Cetuximab [1] Cetuximab[1] Cetuximab 💬 [1] EGFR 💬 [47] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Virion - Hepatitis viruses 💬[5] 34, 51, 86, 89, 331 💬
31 Chlorhexidine [2] Chlorhexidine; Chlorhexidine gluconate[4] Chlorhexidine gluconate ,
Chlorhexidine hydrochloride ,
Chlorhexidine ,
Chlorhexidine acetate 💬 		--[2] 86, 299 💬
32 Cicletanine [2] Cicletanine; Cicletanine hydrochloride[2] Cicletanine ,
Cicletanine hydrochloride 💬 		--[1] 86 💬
33 Clopidogrel [1] Clopidogrel[4] Clopidogrel bisulfate ,
Clopidogrel ,
Clopidogrel hydrochloride ,
Clopidogrel besilate 💬 		[1] P2RY12 💬 [3] Efferocytosis, Neuroactive ligand signaling, Platelet activation 💬[4] 40, 49, 51, 86 💬
34 CXA-10 [1] CXA-10---[2] 86, 222 💬
35 D-glucose [1] D-glucose---[2] 86, 88 💬
36 Dapagliflozin [1] Dapagliflozin[1] Dapagliflozin 💬 --[13] 6, 19, 28, 49, 66, 67, 86, 88, 97, 210, 215, 218, 222 💬
37 Dichloroacetic acid [1] Dichloroacetate[1] Sodium dichloroacetate 💬 [3] PDK2_3_4,
PDK2_3_4,
PDK2_3_4 💬 		[1] Diabetic cardiomyopathy 💬[2] 21, 86 💬
38 Diltiazem [2] Diltiazem; Diltiazem hydrochloride[3] Diltiazem hydrochloride ,
Diltiazem malate ,
Diltiazem 💬 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 51, 58, 86, 88 💬
39 Dimethyl fumarate [2] Dimethyl fumarate; Dimethylfumarat[1] Dimethyl fumarate 💬 [1] KLHL19 💬 [6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[6] 13, 20, 49, 51, 86, 296 💬
40 Diphenhydramine [2] Diphenhydramine; Diphenhydramine hydrochloride[4] Diphenhydramine ,
Diphenhydramine hydrochloride ,
Diphenhydramine salicylate ,
Diphenhydramine citrate 💬 		[1] HRH1 💬 [4] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬[11] 11, 13, 19, 49, 51, 70, 86, 96, 222, 256, 300 💬
41 Dobutamine [2] Dobutamin; Dobutamine[3] Dobutamine hydrochloride ,
Dobutamine ,
Dobutamine tartrate 💬 		[1] ADRB1 💬 [13] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 57, 58, 86, 215 💬
42 Elafin [1] Elafin---[1] 86 💬
43 Empagliflozin [1] Empagliflozin[1] Empagliflozin 💬 --[13] 46, 58, 65, 67, 72, 77, 86, 96, 97, 113, 257, 298, 299 💬
44 Epicatechin [1] Epicatechin---[2] 86, 113 💬
45 Epoprostenol [3] Epoprostenol; Epoprostenol sodium; Prostacyclin[2] Epoprostenol ,
Epoprostenol sodium 💬 		[1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
46 Esomeprazole [3] Esomeprazole; Esomeprazole magnesium; Omeprazole[5] Esomeprazole magnesium ,
Esomeprazole sodium ,
Esomeprazole ,
Esomeprazole strontium ,
Esomeprazole magnesium dihydrate 💬 		[2] ATP4A,
ATP4B 💬 		[3] Collecting duct acid secretion, Gastric acid secretion, Oxidative phosphorylation 💬[10] 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
47 Esuberaprost [1] Esuberaprost[2] Esuberaprost ,
Esuberaprost sodium 💬 		[1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
48 Famotidine [2] Famotidina; Famotidine[1] Famotidine 💬 [1] HRH2 💬 [4] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬[7] 6, 46, 61, 86, 98, 145, 300 💬
49 Ferric carboxymaltose [1] Ferric carboxymaltose[1] Ferric carboxymaltose 💬 --[4] 86, 96, 97, 299 💬
50 Fluoxetine [3] Fluoxetine; Fluoxetine hydrochloride; Fluoxétine[2] Fluoxetine ,
Fluoxetine hydrochloride 💬 		[1] SLC6A4 💬 [3] Neuroactive ligand signaling, Serotonergic synapse, Synaptic vesicle cycle 💬[3] 13, 17, 86 💬
51 Fulvestrant [1] Fulvestrant[1] Fulvestrant 💬 [2] ESR1,
ESR2 💬 		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Estrogen signaling pathway, GnRH secretion, Hormone signaling, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[1] 86 💬
52 Furosemide [1] Furosemide[1] Furosemide 💬 [1] SLC12A2 💬 [3] Pancreatic secretion, Salivary secretion, Vibrio cholerae infection 💬[3] 6, 77, 86 💬
53 Gadolinium [1] Gadolinium---[7] 13, 34, 46, 65, 77, 86, 305 💬
54 GSK2256098 [1] GSK2256098---[1] 86 💬
55 Human interleukin-6 [2] IL-6; Interleukin-6---[6] 46, 49, 51, 70, 86, 107 💬
56 Hydroxyurea [1] Hydroxyurea[1] Hydroxyurea 💬 [1] RRM2 💬 [5] Drug metabolism - other enzymes, Glutathione metabolism, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬[10] 3, 13, 19, 20, 46, 65, 85, 86, 107, 284 💬
57 IKT-001Pro [1] IKT-001PRO---[1] 86 💬
58 Iloprost [1] Iloprost[2] Iloprost ,
Iloprost tromethamine 💬 		[1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[4] 51, 84, 85, 86 💬
59 Imatinib [2] Imatinib; Imatinib mesylate[2] Imatinib mesylate ,
Imatinib 💬 		[3] ABL1,
KIT,
PDGFRA 💬 		[31] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
60 JTT-251 [1] JTT-251---[1] 86 💬
61 Levocarnitine [3] Carnitine; L-carnitine; Levocarnitine[2] Levocarnitine chloride ,
Levocarnitine 💬 		--[11] 2, 3, 13, 46, 53, 58, 86, 96, 97, 240, 265 💬
62 Lidocaine [2] Lidocaine; Lidocaine hydrochloride[3] Lidocaine ,
Lidocaine hydrochloride ,
Lidocaine hydrochloride monohydrate 💬 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[14] 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
63 Lisuride [1] Lisuride[1] Lisuride 💬 [3] DRD2,
DRD3,
DRD4 💬 		[10] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 86 💬
64 Macitentan [1] Macitentan[1] Macitentan 💬 [2] EDNRA,
EDNRB 💬 		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210 💬
65 Medical air [1] Medical AIR[1] Air, medical 💬 --[6] 58, 85, 86, 97, 193, 299 💬
66 Melatonin [1] Melatonin[1] Melatonin 💬 [2] MTNR1A,
MTNR1B 💬 		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[17] 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
67 Metformin [3] Metformin; Metformin hydrochloride; Metformina[2] Metformin hydrochloride ,
Metformin 💬 		[2] PRKAA,
PRKAA 💬 		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[28] 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
68 Methylprednisolone [3] Methylprednisolon; Methylprednisolone; Methylprednisolone acetate[2] Methylprednisolone ,
Methylprednisolone acetate 💬 		[1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[48] 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
69 Morphine [3] Morphine; Morphine hydrochloride; Morphine sulfate[4] Morphine sulfate ,
Morphine hydrochloride hydrate ,
Morphine ,
Morphine tartrate 💬 		[1] OPRM1 💬 [5] Estrogen signaling pathway, Hormone signaling, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬[6] 36, 46, 70, 85, 86, 298 💬
70 Moxifloxacin [2] Moxifloxacin; Moxifloxacin hydrochloride[3] Moxifloxacin hydrochloride ,
Moxifloxacin ,
Moxifloxacin hydrochloride monohydrate 💬 		--[9] 2, 6, 46, 49, 85, 86, 113, 240, 299 💬
71 Nicardipine [1] Nicardipine[2] Nicardipine hydrochloride ,
Nicardipine 💬 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 70, 86 💬
72 Nilotinib [2] Nilotinib; Nilotinib hydrochloride monohydrate[1] Nilotinib 💬 [4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬 		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 6, 8, 34, 51, 86 💬
73 Nitric Oxide [1] Nitric oxide[1] Nitric oxide 💬 --[9] 51, 85, 86, 88, 97, 210, 251, 294, 299 💬
74 Olaparib [1] Olaparib[1] Olaparib 💬 [2] PARP1,
PARP2 💬 		[5] Apoptosis, Base excision repair, Diabetic cardiomyopathy, NF-kappa B signaling pathway, Necroptosis 💬[2] 86, 285 💬
75 Oxygen [1] Oxygen[1] Oxygen 💬 --[18] 6, 19, 22, 49, 70, 85, 86, 88, 96, 97, 149, 168, 211, 235, 271, 298, 299, 330 💬
76 PF-00489791 [1] PF-00489791---[1] 86 💬
77 Pioglitazone [1] Pioglitazone[2] Pioglitazone hydrochloride ,
Pioglitazone 💬 		[1] NR1C3 💬 [12] AMPK signaling pathway, Efferocytosis, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 220, 229, 265, 298, 299 💬
78 PLX-PAD [1] PLX-PAD---[1] 86 💬
79 Prasterone [3] Dehydroepiandrosterone; Dhea; Prasterone[1] Prasterone 💬 [3] AR,
ESR1,
ESR2 💬 		[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Estrogen signaling pathway, GnRH secretion, Hormone signaling, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[6] 49, 53, 83, 86, 96, 113 💬
80 Prednisone [2] Prednisona; Prednisone[1] Prednisone 💬 [1] NR3C1 💬 [1] Neuroactive ligand-receptor interaction 💬[54] 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
81 Ralinepag [1] Ralinepag[1] Ralinepag 💬 [1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
82 Ranolazine [1] Ranolazine[2] Ranolazine ,
Ranolazine hydrochloride 💬 		--[7] 2, 58, 86, 96, 97, 113, 114 💬
83 Rifampin [2] Rifampicin; Rifampin[2] Rifampin ,
Rifampicin sodium 💬 		--[10] 6, 13, 17, 46, 84, 86, 93, 97, 299, 338 💬
84 Riociguat [1] Riociguat[1] Riociguat 💬 [3] GUCY1A,
GUCY1A,
GUCY1B 💬 		[10] Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[6] 51, 84, 86, 88, 225, 299 💬
85 Ritonavir [1] Ritonavir[1] Ritonavir 💬 --[3] 2, 86, 265 💬
86 Rituximab [1] Rituximab[1] Rituximab 💬 [1] MS4A1 💬 [1] Hematopoietic cell lineage 💬[52] 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
87 Rodatristat [0] [1] Rodatristat 💬 [1] TPH1_2 💬 [3] Folate biosynthesis, Serotonergic synapse, Tryptophan metabolism 💬[1] 86 💬
88 Rodatristat ethyl [1] Rodatristat ethyl[1] Rodatristat ethyl 💬 [1] TPH1_2 💬 [3] Folate biosynthesis, Serotonergic synapse, Tryptophan metabolism 💬[1] 86 💬
89 Sapropterin [4] 6R-BH4; Sapropterin; Sapropterin dihydrochloride; Tetrahydrobiopterin[2] Sapropterin dihydrochloride ,
Sapropterin 💬 		--[3] 86, 124, 240 💬
90 Saquinavir [1] Saquinavir[2] Saquinavir ,
Saquinavir mesylate 💬 		--[2] 86, 265 💬
91 Satralizumab [2] Sapelizumab; Satralizumab[1] Satralizumab 💬 [1] IL6R 💬 [11] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[4] 11, 13, 86, 113 💬
92 Selexipag [1] Selexipag[1] Selexipag 💬 [1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 47, 51, 70, 84, 86, 88 💬
93 Selonsertib [1] Selonsertib[1] Selonsertib 💬 [1] MAP3K5 💬 [19] Alcoholic liver disease, Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Huntington disease, Lipid and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, Spinocerebellar ataxia, TNF signaling pathway, Thermogenesis, Tight junction 💬[1] 86 💬
94 Seralutinib [1] Seralutinib[1] Seralutinib 💬 [2] PDGFRA,
PDGFRB 💬 		[20] Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Endocytosis, Focal adhesion, Gap junction, Glioma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton 💬[1] 86 💬
95 Serine [1] Serine[1] Serine 💬 --[1] 86 💬
96 Sildenafil [3] Sildenafil; Sildenafil citrate; Sildenafilo[2] Sildenafil citrate ,
Sildenafil 💬 		[1] PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[14] 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
97 Simvastatin [2] Simvastatin; Simvastatine[1] Simvastatin 💬 [1] HMGCR 💬 [3] AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
98 Sirolimus [2] Rapamycin; Sirolimus[1] Sirolimus 💬 [1] MTOR 💬 [49] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[46] 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
99 Sitaxentan [3] Sitaxentan; Sitaxentan sodium; Sitaxsentan[2] Sitaxentan ,
Sitaxentan sodium 💬 		[1] EDNRA 💬 [7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
100 Sodium dichloroacetate [1] Dichloroacetate sodium---[1] 86 💬
101 Sorafenib [1] Sorafenib[2] Sorafenib tosylate ,
Sorafenib 💬 		[8] BRAF,
FLT3,
FLT4,
KDR,
KIT,
PDGFRB,
RAF1,
RET 💬 		[87] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 34, 86 💬
102 Sotatercept [1] Sotatercept[1] Sotatercept 💬 [1] ACVR2A 💬 [4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[2] 86, 284 💬
103 Spironolactone [1] Spironolactone[1] Spironolactone 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225 💬
104 Sulfasalazine [4] Salazosulfapyridine; Salicylazosulfapyridine; Sulfasalazin; Sulfasalazine[1] Sulfasalazine 💬 --[8] 46, 49, 54, 86, 94, 107, 270, 271 💬
105 Tadalafil [2] Tadalafil; Tadalafilo[1] Tadalafil 💬 [1] PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[8] 6, 51, 75, 77, 84, 86, 113, 210 💬
106 Tamoxifen [2] Tamoxifen; Tamoxifen citrate[2] Tamoxifen citrate ,
Tamoxifen 💬 		[2] ESR1,
ESR2 💬 		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Estrogen signaling pathway, GnRH secretion, Hormone signaling, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[4] 2, 86, 113, 227 💬
107 Terguride [1] Terguride[1] Terguride 💬 [2] DRD2,
PRL 💬 		[14] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, Hormone signaling, JAK-STAT signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 51, 86 💬
108 Tezosentan [1] Tezosentan---[1] 86 💬
109 Threonine [1] Threonine[1] Threonine 💬 --[3] 86, 96, 97 💬
110 Tocilizumab [1] Tocilizumab[1] Tocilizumab 💬 [1] IL6R 💬 [11] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[24] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
111 Tolvaptan [1] Tolvaptan[1] Tolvaptan 💬 [1] AVPR2 💬 [4] Hormone signaling, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[4] 67, 72, 86, 225 💬
112 Treprostinil [3] Treprostinil; Treprostinil diolamine; Treprostinil sodium[3] Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		[1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[5] 51, 85, 86, 88, 210 💬
113 Treprostinil palmitil [1] Treprostinil palmitil[1] Treprostinil palmitil 💬 [1] PTGIR 💬 [3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
114 Trimetazidine [2] Trimetazidine; Trimetazidine dihydrochloride[2] Trimetazidine hydrochloride ,
Trimetazidine 💬 		--[3] 2, 58, 86 💬
115 Tyrosine [3] Alanine; Propanoic acid; Tyrosine[1] Tyrosine 💬 --[5] 6, 75, 77, 86, 298 💬
116 Ubenimex [1] Ubenimex[1] Ubenimex 💬 [1] ANPEP 💬 [3] Glutathione metabolism, Hematopoietic cell lineage, Renin-angiotensin system 💬[1] 86 💬
117 Ubidecarenone [2] Coenzyme Q10; COQ10[1] Ubidecarenone 💬 --[14] 2, 5, 6, 8, 10, 46, 57, 86, 96, 107, 113, 193, 214, 215 💬
118 Udenafil [1] Udenafil[1] Udenafil 💬 [1] PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 210 💬
119 Ularitide [1] Ularitide---[1] 86 💬
120 Valsartan [1] Valsartan[1] Valsartan 💬 [1] AGTR1 💬 [17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[8] 57, 58, 66, 75, 86, 210, 222, 224 💬
121 Vardenafil [1] Vardenafil[2] Vardenafil ,
Vardenafil hydrochloride 💬 		[1] PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway 💬[3] 13, 86, 299 💬
122 Vasoactive intestinal peptide [0] ---[3] 49, 51, 86 💬
123 Vasomera [0] ---[1] 86 💬
124 Vericiguat [1] Vericiguat[1] Vericiguat 💬 [3] GUCY1A,
GUCY1A,
GUCY1B 💬 		[10] Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 86 💬
125 Warfarin [3] Warfarin; Warfarin potassium; Warfarin sodium[3] Warfarin sodium ,
Warfarin potassium ,
Warfarin 💬 		[2] NQO1,
VKORC1 💬 		[5] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[12] 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
126 Zamicastat [1] Zamicastat---[1] 86 💬