Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MAPK14 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
2 MAPK14 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
3 IFNA1 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
4 IFNA1 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
5 IFNA2 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
6 IFNA2 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
7 IFNA4 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
8 IFNA4 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
9 IFNA5 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
10 IFNA5 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
11 IFNA6 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
12 IFNA6 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
13 IFNA7 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
14 IFNA7 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
15 IFNA8 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
16 IFNA8 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
17 IFNA10 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
18 IFNA10 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
19 IFNA13 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
20 IFNA13 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
21 IFNA14 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
22 IFNA14 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
23 IFNA16 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
24 IFNA16 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
25 IFNA17 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
26 IFNA17 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
27 IFNA21 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab 1件: 49
28 IFNA21 3件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab 1件: 49
29 IL12A 6件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
30 IL12B 6件: Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
31 NFKB1 15件: Sphingolipid signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Small cell lung cancer D01146 Iguratimod 4件: 46, 51, 53, 271
32 MAPK11 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
33 MAPK11 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
34 MAPK13 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
35 MAPK13 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
36 RELA 15件: Sphingolipid signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Small cell lung cancer D12181 Edasalonexent 1件: 113
37 MAPK12 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
38 MAPK12 15件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
39 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00742 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298
40 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
41 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
42 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02597 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271
43 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02598 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
44 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D03441 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271
45 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04358 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271
46 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
47 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D05393 Pegsunercept 1件: 46
48 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D08976 Pomalidomide 6件: 28, 34, 51, 85, 227, 331
49 TNF 15件: Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D09944 Ozoralizumab 1件: 46