Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MAPK14 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
2 MAPK14 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
3 HLA-DMA 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
4 HLA-DMB 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
5 HLA-DOA 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
6 HLA-DOB 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
7 HLA-DPA1 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
8 HLA-DPB1 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
9 HLA-DQA1 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
10 HLA-DQA2 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
11 HLA-DQB1 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
12 HLA-DRA 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
13 HLA-DRB1 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
14 HLA-DRB3 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
15 HLA-DRB4 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
16 HLA-DRB5 6件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Viral myocarditis D04318 Glatiramer 4件: 2, 13, 96, 156
17 IFNG 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D04242 Fontolizumab 1件: 46
18 IFNG 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D11120 Emapalumab 2件: 49, 107
19 IFNGR1 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
20 IFNGR2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
21 IL2RA 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin 6件: 2, 35, 49, 65, 96, 97
22 IL2RA 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D03058 Basiliximab 6件: 2, 50, 66, 97, 222, 228
23 IL2RA 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D03639 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284
24 IL2RB 4件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation, Transcriptional misregulation in cancer D00748 Aldesleukin 6件: 2, 35, 49, 65, 96, 97
25 IL2RG 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin 6件: 2, 35, 49, 65, 96, 97
26 IL4 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D03117 Binetrakin 1件: 46
27 IL4R 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D10354 Dupilumab 4件: 51, 98, 160, 162
28 IL5 1件: Th1 and Th2 cell differentiation D04923 Mepolizumab 4件: 44, 45, 98, 162
29 IL5 1件: Th1 and Th2 cell differentiation D08985 Reslizumab 2件: 44, 98
30 IL12A 5件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
31 IL12B 5件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
32 IL13 1件: Th1 and Th2 cell differentiation D08857 Anrukinzumab 1件: 97
33 IL13 1件: Th1 and Th2 cell differentiation D09633 Lebrikizumab 1件: 85
34 IL13 1件: Th1 and Th2 cell differentiation D09979 Tralokinumab 2件: 85, 97
35 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09959 Ruxolitinib 1件: 228
36 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
37 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10308 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
38 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10653 Peficitinib 1件: 46
39 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10871 Filgotinib 6件: 46, 53, 96, 97, 222, 271
40 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10944 Itacitinib 5件: 46, 51, 60, 97, 228
41 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10994 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271
42 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09959 Ruxolitinib 1件: 228
43 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
44 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D10308 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
45 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D10653 Peficitinib 1件: 46
46 JAK3 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
47 JAK3 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis D10653 Peficitinib 1件: 46
48 LCK 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Yersinia infection D03658 Dasatinib 2件: 51, 85
49 LCK 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Yersinia infection D06414 Dasatinib 2件: 51, 85
50 NFKB1 9件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod 4件: 46, 51, 53, 271
51 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
52 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
53 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
54 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
55 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 1件: 222
56 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
57 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
58 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
59 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
60 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 1件: 222
61 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
62 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
63 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
64 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
65 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 1件: 222
66 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
67 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
68 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
69 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
70 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 1件: 222
71 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
72 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
73 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
74 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
75 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 1件: 222
76 PRKCQ 3件: Vascular smooth muscle contraction, Th1 and Th2 cell differentiation, Th17 cell differentiation D09671 Sotrastaurin 1件: 97
77 MAPK11 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
78 MAPK11 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
79 MAPK13 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
80 MAPK13 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
81 RELA 9件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent 1件: 113
82 MAPK12 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
83 MAPK12 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
84 TYK2 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
85 TYK2 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis D11817 Deucravacitinib 2件: 96, 97
86 CD3D 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D05092 Muromonab 3件: 60, 96, 97
87 CD3D 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab 2件: 96, 97
88 CD3D 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab 1件: 46
89 CD3E 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D05092 Muromonab 3件: 60, 96, 97
90 CD3E 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab 2件: 96, 97
91 CD3E 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab 1件: 46
92 CD3E 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D11463 Mosunetuzumab 1件: 49
93 CD3G 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D05092 Muromonab 3件: 60, 96, 97
94 CD3G 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab 2件: 96, 97
95 CD3G 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab 1件: 46