Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Amiloride
(Synonym: Midamor Tablets 5mg)		[3] Amiloride; Amiloride Hydrochloride; Midamor[1] D07447 [3] SCNN1A,
SCNN1B,
SCNN1G 💬		[2] Aldosterone-regulated sodium reabsorption, Taste transduction 💬[4] 13, 67, 225, 299
2 Amlodipine
(Synonym: Ratio-amlodipine Tablets 5mg)		[1] Amlodipine[1] D07450 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 13, 51, 67, 298
3 Benazepril
(Synonym: Lotensin 5mg)		[1] Benazepril[1] D07499 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[4] 49, 57, 218, 224
4 Bendroflumethiazide
(Synonym: Naturetin 5mg)		[1] BENDROFLUMETHIAZIDE[1] D00650 [1] SLC12A3 💬-[1] 67
5 Betamethasone
(Synonym: Betnesol Retention Enema 5mg/100ml)		[1] Betamethasone[1] D00244 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[8] 2, 28, 46, 65, 83, 90, 96, 235
6 Bethanechol
(Synonym: Urecholine Inj 5mg/ml)		[1] Bethanechol---[1] 98
7 Bisacodyl
(Synonym: Correctol Laxative - Ect 5mg)		[1] Bisacodyl[1] D00245 --[1] 13
8 Bromocriptine
(Synonym: Parlodel Cap 5mg)		[1] BROMOCRIPTINE[1] D03165 [2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 74
9 Cisapride
(Synonym: Prepulsid Tab 5mg)		[1] CISAPRIDE[2] D00274 ,
D02092 		[3] HTR2A,
HTR3A,
HTR4 💬		[7] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[1] 13
10 Copper
(Synonym: Copper Chelate - 5mg Tab)		[2] Copper; Nicotinamide---[4] 2, 169, 170, 171
11 Cortisone acetate
(Synonym: Cortone Tab 5mg)		[1] Cortisone acetate[1] D00973 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 81
12 Daclizumab
(Synonym: Zenapax 5mg/ml)		[3] DACLIZUMAB; Zenapax; Zinbryta[1] D03639 [1] IL2RA 💬[11] Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, JAK-STAT signaling pathway, Measles, PI3K-Akt signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[8] 13, 56, 60, 65, 97, 107, 283, 284
13 Diazepam
(Synonym: Valium Inj Roche 5mg/ml)		[1] Diazepam[1] D00293 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 46, 155, 298
14 Diltiazem
(Synonym: Cardizem Injectable Liq 5mg/ml)		[2] Diltiazem; Diltiazem Hydrochloride[1] D07845 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 58, 86
15 Donepezil
(Synonym: Donepezil Hyrochloride 5mg)		[3] ARICEPT; Donepezil; Donepezil Hydrochloride[1] D07869 [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
16 Enalapril
(Synonym: Apo-enalapril Tab 5mg)		[2] Enalapril; Enalapril Maleate[1] D07892 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[6] 19, 46, 66, 113, 210, 222
17 Erythromycin
(Synonym: Erymycin Ophthalmic Ointment 5mg/g)		[1] Erythromycin[1] D00140 --[5] 6, 36, 164, 228, 291
18 Escitalopram
(Synonym: Cipralex -5mg)		[3] Citalopram; Escitalopram; Escitalopram oxalate[1] D07913 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 2, 6, 13, 46
19 Flunarizine
(Synonym: Novo-flunarizine - Cap 5mg)		[0] [1] D07971 [3] CACNA1G,
CACNA1H,
CACNA1I 💬		[8] Aldosterone synthesis and secretion, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GnRH secretion, MAPK signaling pathway, Type II diabetes mellitus 💬[1] 149
20 Folic acid
(Synonym: Folvite Inj 5mg/ml)		[5] Acide folique; Folate; Folic acid; Multivitamin; Nicotinamide[1] D00070 --[6] 6, 41, 46, 49, 84, 296
21 Gentamicin
(Synonym: Garatec Otic Dps 5mg/ml)		[2] Gentamicin; Gentamicin Sulfate[1] D08013 --[3] 36, 113, 299
22 Haloperidol
(Synonym: Haldol Injection 5mg/ml)		[1] Haloperidol[1] D00136 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 8
23 Isosorbide dinitrate
(Synonym: Isosorbide-5 Tab 5mg)		[2] Isosorbide; ISOSORBIDE DINITRATE[1] D00516 --[1] 113
24 Leucovorin
(Synonym: Leucovorin Calcium Tab 5mg)		[2] Folinic acid; Leucovorin[2] D07986 ,
D07987 		--[4] 19, 46, 107, 320
25 Levofloxacin
(Synonym: Levaquin 5mg/ml)		[2] Levaquin; Levofloxacin[2] D00588 ,
D08120 		--[5] 46, 53, 84, 85, 299
26 Lisinopril
(Synonym: Lisinopril 5mg)		[2] Lisinopril; Zestril[2] D00362 ,
D08131 		[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 19, 46, 49, 66, 67, 113, 222
27 Medroxyprogesterone acetate
(Synonym: Gen-medroxy Tablet 5mg)		[1] Medroxyprogesterone[1] D00951 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[8] 13, 35, 46, 49, 50, 51, 60, 107
28 Metoclopramide
(Synonym: Maxeran 5mg Tab)		[1] METOCLOPRAMIDE[1] D00726 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 46, 51
29 Midazolam
(Synonym: Versed Inj 5mg/ml)		[2] Midazolam; Midazolam injection[1] D00550 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299
30 Mitomycin
(Synonym: Mutamycin Inj 5mg/vial)		[2] Mitomycin; Mitomycin C[1] D00208 --[3] 94, 118, 329
31 Morphine
(Synonym: Statex Suppositories 5mg)		[2] Morphine; Morphine Sulfate[1] D08233 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[5] 36, 46, 70, 85, 86
32 Nifedipine
(Synonym: Novo-nifedin Cap 5mg)		[1] Nifedipine[1] D00437 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 50, 81
33 Nitroglycerin
(Synonym: Nitroject Inj 5mg/ml)		[2] Nitroglycerin; Nitroglycerine[1] D00515 --[2] 46, 51
34 Olanzapine
(Synonym: Zyprexa - 5mg)		[2] Olanzapine; Zyprexa[1] D00454 [11] ADRA1A,
ADRA1B,
ADRA1D,
DRD2,
DRD3,
DRD4,
HRH1,
HTR2A,
HTR2B,
HTR2C,
HTR6 💬		[16] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 8
35 Oxybutynin
(Synonym: Oxybutynine-5 - Tab 5mg)		[1] Oxybutynin[1] D00465 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[3] 6, 13, 53
36 Oxycodone
(Synonym: Oxycontin 5mg)		[2] Oxycodone; OXYCODONE HYDROCHLORIDE[1] D05312 [3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[5] 6, 13, 70, 226, 298
37 Oxymorphone
(Synonym: Numorphan Suppository 5mg)		[1] Opana[1] D08323 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
38 Phenylephrine
(Synonym: Novahistine Decon Liq 5mg/5ml)		[1] Phenylephrine[1] D08365 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 22
39 Prednisolone
(Synonym: Novo-prednisolone 5mg)		[3] Prednisolona; PREDNISOLONE; Prednisolonum[1] D00472 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[42] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300
40 Prednisone
(Synonym: Jaa Prednisone Tab 5mg USP)		[3] Prednisona; Prednisone; RAYOS[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331
41 Pyridostigmine
(Synonym: Regonol Inj 5mg/ml)		[3] Mestinon; Pyridostigmine; PYRIDOSTIGMINE BROMIDE---[4] 3, 6, 11, 256
42 Quinapril
(Synonym: Accupril 5mg Tab)		[1] Accuretic[1] D03752 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 19
43 Ramipril
(Synonym: Altace Plus Felodipine 5mg + 5mg)		[1] Ramipril[1] D00421 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 46, 49, 66, 67, 113, 218, 257
44 Riboflavin
(Synonym: Riboflavin Tab 5mg)		[2] Riboflavin; Vitamin B2[1] D00050 --[7] 38, 46, 96, 97, 162, 168, 265
45 Rosuvastatin
(Synonym: Crestor - 5mg)		[3] Crestor; Rosuvastatin; ROSUVASTATIN CALCIUM[1] D08492 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
46 Salbutamol
(Synonym: Ventolin Respirator Solution 5mg/ml)		[3] Albuterol; SALBUTAMOL; Ventolin[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[12] 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299
47 Selegiline
(Synonym: Eldepryl - 5mg Tab)		[2] SELEGILINE; Zelapar[1] D03731 [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
48 Simvastatin
(Synonym: Simvastatin Tablets 5mg)		[3] Simvastatin; Simvastatina; Simvastatine[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
49 Somatotropin
(Synonym: Nutropin AQ - Sc 5mg/ml)		[17] Genotropin; Growth hormone; Human growth hormone; Humatrope; Norditropin; Norditropin SimpleXx; NUTROPIN; Nutropin AQ; NutropinAq; OMNITROPE; Recombinant human growth hormone; RhGH; SAIZEN; Somatotropin; Somatropin; SOMATROPINA; Zomacton---[25] 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 246, 265, 274, 276, 299, 337
50 Terazosin
(Synonym: Ratio-terazosin - Tab 5mg)		[1] Terazosin[1] D08569 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 6
51 Timolol
(Synonym: Nu-timolol Tab 5mg)		[2] Timolol; TIMOLOL MALEATE[2] D00378 ,
D08600 		[2] ADRB1,
ADRB2 💬		[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 157, 227
52 Trifluoperazine
(Synonym: PMS Trifluoperazine Tab 5mg)		[1] Trifluoperazine[2] D01448 ,
D08636 		[1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 283, 284
53 Trihexyphenidyl
(Synonym: Aparkane Tab 5mg)		[1] Trihexyphenidyl[1] D08638 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 5, 6
54 Vincristine
(Synonym: Vincristine Sulfate Inj 5mg/vial USP)		[2] Vincristine; Vincristine Sulfate[1] D08679 [9] TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬		[10] Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬[4] 26, 34, 65, 331
55 Warfarin
(Synonym: Coumadin Tab 5mg)		[2] Warfarin; Warfarin Sodium[1] D08682 [2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
56 Water
(Synonym: Protropin Pws 5mg/vial)		[8] AVONEX; ENBREL; Hiberix; Indocyanine green; OMNITROPE; Sterile Water for Injection; Water; WATER FOR INJECTION[1] D00001 --[21] 2, 5, 6, 13, 17, 22, 35, 46, 53, 57, 63, 65, 67, 78, 84, 96, 97, 206, 226, 278, 299