Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alanine, aspartate and glutamate metabolism 💬
 [1] ABAT 💬 Vigabatrin 💬 Vigabatrin [2] 145, 158 💬
2 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
3 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
4 Amyotrophic lateral sclerosis 💬
 [1] SIGMAR1 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
5 beta-Alanine metabolism 💬
 [1] ABAT 💬 Vigabatrin 💬 Vigabatrin [2] 145, 158 💬
6 Butanoate metabolism 💬
 [1] ABAT 💬 Vigabatrin 💬 Vigabatrin [2] 145, 158 💬
7 Calcium signaling pathway 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
8 cAMP signaling pathway 💬
 [1] HTR1D 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
9 cAMP signaling pathway 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
10 cAMP signaling pathway 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
11 Circadian entrainment 💬
 [2] MTNR1A, MTNR1B 💬 Melatonin 💬 Melatonin [12]  6 ,  8 , 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
12 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
13 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
14 Cushing syndrome 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
15 Cushing syndrome 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
16 GABAergic synapse 💬
 [1] ABAT 💬 Vigabatrin 💬 Vigabatrin [2] 145, 158 💬
17 GABAergic synapse 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
18 Gap junction 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
19 Inflammatory mediator regulation of TRP channels 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
20 Metabolic pathways 💬
 [1] ABAT 💬 Vigabatrin 💬 Vigabatrin [2] 145, 158 💬
21 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
22 Neuroactive ligand-receptor interaction 💬
 [2] CNR1, CNR2 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
23 Neuroactive ligand-receptor interaction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
24 Neuroactive ligand-receptor interaction 💬
 [3] HTR1D, HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
25 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
26 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
27 Neuroactive ligand-receptor interaction 💬
 [2] MTNR1A, MTNR1B 💬 Melatonin 💬 Melatonin [12]  6 ,  8 , 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
28 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Methylprednisolone 💬 Methylprednisolone [46]  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
29 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Prednisolone 💬 Prednisolone [42]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
30 Nicotine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
31 Pathways of neurodegeneration - multiple diseases 💬
 [1] SIGMAR1 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
32 Propanoate metabolism 💬
 [1] ABAT 💬 Vigabatrin 💬 Vigabatrin [2] 145, 158 💬
33 Rap1 signaling pathway 💬
 [1] CNR1 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
34 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
35 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
36 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
37 Serotonergic synapse 💬
 [4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
38 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
39 Taste transduction 💬
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
40 Taste transduction 💬
 [1] HTR1D 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
41 Thermogenesis 💬
 [1] CNR1 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
42 Valine, leucine and isoleucine degradation 💬
 [1] ABAT 💬 Vigabatrin 💬 Vigabatrin [2] 145, 158 💬

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