Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
2 Alcoholism 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
3 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
4 Amphetamine addiction 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
5 Amphetamine addiction 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
6 AMPK signaling pathway 💬
 [1] HMGCR 💬 Rosuvastatin 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
7 Amyotrophic lateral sclerosis 💬
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
8 Bile secretion 💬
 [1] HMGCR 💬 Rosuvastatin 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
9 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
10 cAMP signaling pathway 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
11 cAMP signaling pathway 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
12 Chagas disease 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
13 Chemical carcinogenesis - reactive oxygen species 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
14 Chemical carcinogenesis - receptor activation 💬
 [2] CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline [3]  6 , 18, 53 💬
15 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Calcitriol 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
16 Cholinergic synapse 💬
 [2] CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline [3]  6 , 18, 53 💬
17 Circadian entrainment 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
18 Cocaine addiction 💬
 [6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
19 Cocaine addiction 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
20 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 Lenograstim 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
21 Cytokine-cytokine receptor interaction 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
22 Dopaminergic synapse 💬
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
23 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
24 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] VDR 💬 Calcitriol 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
25 Estrogen signaling pathway 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
26 Fluid shear stress and atherosclerosis 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
27 GABAergic synapse 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
28 GABAergic synapse 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
29 Glutamatergic synapse 💬
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
30 GnRH secretion 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
31 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 Lenograstim 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
32 Hepatocellular carcinoma 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
33 Herpes simplex virus 1 infection 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
34 HIF-1 signaling pathway 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
35 Huntington disease 💬
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
36 Inflammatory bowel disease 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
37 Influenza A 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
38 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 Lenograstim 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
39 JAK-STAT signaling pathway 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
40 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] IFNGR1 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
41 Leishmaniasis 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
42 Lipid and atherosclerosis 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
43 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
44 Long-term potentiation 💬
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
45 Metabolic pathways 💬
 [1] HMGCR 💬 Rosuvastatin 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
46 Mineral absorption 💬
 [1] VDR 💬 Calcitriol 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
47 Morphine addiction 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
48 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
49 Natural killer cell mediated cytotoxicity 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
50 Necroptosis 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
51 Neuroactive ligand-receptor interaction 💬
 [2] CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline [3]  6 , 18, 53 💬
52 Neuroactive ligand-receptor interaction 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
53 Neuroactive ligand-receptor interaction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
54 Neuroactive ligand-receptor interaction 💬
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
55 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Methylprednisolone 💬 Methylprednisolone [46]  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
56 Nicotine addiction 💬
 [2] CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline [3]  6 , 18, 53 💬
57 Nicotine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
58 Nicotine addiction 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
59 Osteoclast differentiation 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
60 Parathyroid hormone synthesis, secretion and action 💬
 [1] VDR 💬 Calcitriol 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
61 Parkinson disease 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
62 Parkinson disease 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
63 Pathways in cancer 💬
 [1] CSF3R 💬 Lenograstim 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
64 Pathways in cancer 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
65 Pathways in cancer 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
66 Pathways of neurodegeneration - multiple diseases 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
67 Pathways of neurodegeneration - multiple diseases 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
68 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
69 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 Lenograstim 💬 Lenograstim [7]  2 , 13, 16, 18, 19, 57, 65 💬
70 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
71 Protein processing in endoplasmic reticulum 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
72 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
73 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
74 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
75 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
76 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
77 Serotonergic synapse 💬
 [1] SLC6A4 💬 Citalopram 💬 Citalopram [7]  6 ,  8 , 13, 18, 46, 98, 127 💬
78 Spinocerebellar ataxia 💬
 [8] GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
79 Synaptic vesicle cycle 💬
 [2] SLC6A2, SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
80 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Citalopram 💬 Citalopram [7]  6 ,  8 , 13, 18, 46, 98, 127 💬
81 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
82 Taste transduction 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
83 Taste transduction 💬
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
84 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 Rosuvastatin 💬 Rosuvastatin [11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
85 Th1 and Th2 cell differentiation 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
86 Th17 cell differentiation 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
87 Toxoplasmosis 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
88 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
89 Tuberculosis 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
90 Tuberculosis 💬
 [1] VDR 💬 Calcitriol 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬

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