Gene

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

Adherens junction 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Adherens junction 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Adipocytokine signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Adipocytokine signaling pathway 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

Adrenergic signaling in cardiomyocytes 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

AGE-RAGE signaling pathway in diabetic complications 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Alcoholic liver disease 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Alcoholism 💬

[1] DRD2 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

Alcoholism 💬

[11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬

Name	Full Name
HDAC1	histone deacetylase 1
HDAC10	histone deacetylase 10
HDAC11	histone deacetylase 11
HDAC2	histone deacetylase 2
HDAC3	histone deacetylase 3
HDAC4	histone deacetylase 4
HDAC5	histone deacetylase 5
HDAC6	histone deacetylase 6
HDAC7	histone deacetylase 7
HDAC8	histone deacetylase 8
HDAC9	histone deacetylase 9

Vorinostat 💬

[2] 75, 96 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

[1] CYP11A1 💬

[1] 75 💬

[1] CYP11B2 💬

Osilodrostat 💬

Osilodrostat

[1] 75 💬

[1] MC2R 💬

[12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
84	Sarcoidosis;
145	West syndrome;Infantile spasm;
222	Primary nephrotic syndrome;

Aldosterone-regulated sodium reabsorption 💬

[1] NR3C2 💬

Eplerenone 💬

Eplerenone

[4] 75, 113, 210, 215 💬

Disease ID	Name
75	Cushing disease;Cushing;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;

Amphetamine addiction 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

AMPK signaling pathway 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

AMPK signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Amyotrophic lateral sclerosis 💬

[1] HDAC6 💬

Vorinostat 💬

[2] 75, 96 💬

Apelin signaling pathway 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Apelin signaling pathway 💬

[2] HDAC4, HDAC5 💬

Vorinostat 💬

[2] 75, 96 💬

Apelin signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Autophagy - animal 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Bile secretion 💬

[1] RXRA 💬

Bexarotene 💬

[2] 13, 75 💬

Bladder cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Bladder cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Breast cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Breast cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Breast cancer 💬

[1] PGR 💬

Mifepristone 💬

[1] 75 💬

Calcium signaling pathway 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Calcium signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Calcium signaling pathway 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

[2] CRHR1, CRHR2 💬

Corticorelin 💬

[1] 75 💬

[2] CRHR1, CRHR2 💬

[1] 75 💬

[1] DRD2 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

[1] GLP1R 💬

Liraglutide 💬

Liraglutide

[3] 6 , 75, 193 💬

[1] MC2R 💬

[12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
84	Sarcoidosis;
145	West syndrome;Infantile spasm;
222	Primary nephrotic syndrome;

[3] SSTR1, SSTR2, SSTR5 💬

Pasireotide 💬

[3] 67, 74, 75 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

[1] SSTR2 💬

Octreotide 💬

[7] 67, 75, 84, 85, 89, 193, 227 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
193	Prader-Willi syndrome;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;

Cell cycle 💬

[3] HDAC1, HDAC2, HDAC8 💬

Vorinostat 💬

[2] 75, 96 💬

Central carbon metabolism in cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Central carbon metabolism in cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

cGMP-PKG signaling pathway 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

cGMP-PKG signaling pathway 💬

[1] PDE5A 💬

Tadalafil 💬

Tadalafil

[7] 6 , 51, 75, 84, 86, 113, 210 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Chemical carcinogenesis - reactive oxygen species 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Chemical carcinogenesis - reactive oxygen species 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

[1] PGR 💬

Mifepristone 💬

[1] 75 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

Choline metabolism in cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Choline metabolism in cancer 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Chronic myeloid leukemia 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

Circadian rhythm 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Cocaine addiction 💬

[1] DRD2 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

Colorectal cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Colorectal cancer 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Complement and coagulation cascades 💬

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Complement and coagulation cascades 💬

[1] F2 💬

[2] 51, 75 💬

Complement and coagulation cascades 💬

[1] F8 💬

Desmopressin 💬

[6] 6 , 64, 72, 75, 225, 288 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
64	Thrombotic thrombocytopenic purpura;TTP;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
75	Cushing disease;Cushing;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

[1] F2 💬

[2] 51, 75 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

[3] CYP11A1, CYP11B1, CYP17A1 💬

[1] 75 💬

[1] CYP11B1 💬

Metyrapone 💬

[1] 75 💬

[1] CYP17A1 💬

Ketoconazole 💬

[3] 8 , 13, 75 💬

[1] MC2R 💬

[12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
84	Sarcoidosis;
145	West syndrome;Infantile spasm;
222	Primary nephrotic syndrome;

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

[2] CRHR1, CRHR2 💬

Corticorelin 💬

[1] 75 💬

[2] CRHR1, CRHR2 💬

[1] 75 💬

[3] CYP11A1, CYP11B1, CYP17A1 💬

[1] 75 💬

[1] CYP11B1 💬

Metyrapone 💬

[1] 75 💬

[1] CYP17A1 💬

Ketoconazole 💬

[3] 8 , 13, 75 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

[1] MC2R 💬

[12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
84	Sarcoidosis;
145	West syndrome;Infantile spasm;
222	Primary nephrotic syndrome;

Cytokine-cytokine receptor interaction 💬

[1] PRL 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Dopaminergic synapse 💬

[1] DRD2 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

EGFR tyrosine kinase inhibitor resistance 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Endocrine resistance 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Endocrine resistance 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Endocytosis 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Endocytosis 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Endocytosis 💬

[1] PML 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

Endometrial cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

Endometrial cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Epithelial cell signaling in Helicobacter pylori infection 💬

[3] 34, 74, 75 💬

[1] EGFR 💬

Gefitinib 💬

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] 75 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

Epstein-Barr virus infection 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

ErbB signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

ErbB signaling pathway 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

[1] PGR 💬

Mifepristone 💬

[1] 75 💬

100

[1] RARA 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

101

Fluid shear stress and atherosclerosis 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

102

Focal adhesion 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

103

Focal adhesion 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

104

FoxO signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

105

FoxO signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

106

FoxO signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

107

GABAergic synapse 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Alprazolam 💬

[2] 8 , 75 💬

108

GABAergic synapse 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

109

Gap junction 💬

[1] DRD2 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

110

Gap junction 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

111

Gap junction 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

112

Gastric acid secretion 💬

[1] SSTR2 💬

Octreotide 💬

[7] 67, 75, 84, 85, 89, 193, 227 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
193	Prader-Willi syndrome;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;

113

Gastric acid secretion 💬

[1] SSTR2 💬

Pasireotide 💬

[3] 67, 74, 75 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

114

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

115

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

116

[1] RARB 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

117

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

118

Glioma 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

119

Glioma 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

120

Glucagon signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

121

GnRH signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

122

GnRH signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

123

Growth hormone synthesis, secretion and action 💬

[4] SSTR1, SSTR2, SSTR3, SSTR5 💬

Pasireotide 💬

[3] 67, 74, 75 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

124

Growth hormone synthesis, secretion and action 💬

[1] SSTR2 💬

Octreotide 💬

[7] 67, 75, 84, 85, 89, 193, 227 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
193	Prader-Willi syndrome;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;

125

Hepatitis C 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

126

Hepatitis C 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

127

Hepatitis C 💬

[1] RXRA 💬

Bexarotene 💬

[2] 13, 75 💬

128

Hepatocellular carcinoma 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

129

Hepatocellular carcinoma 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

130

Herpes simplex virus 1 infection 💬

[1] PML 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

131

HIF-1 signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

132

HIF-1 signaling pathway 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

133

Human cytomegalovirus infection 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

134

Human cytomegalovirus infection 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

135

Human papillomavirus infection 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

136

Human papillomavirus infection 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

137

Human papillomavirus infection 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

138

Huntington disease 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

139

Huntington disease 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

140

Hypertrophic cardiomyopathy 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

141

Influenza A 💬

[1] PML 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

142

Insulin resistance 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

143

Insulin secretion 💬

[1] GLP1R 💬

Liraglutide 💬

Liraglutide

[3] 6 , 75, 193 💬

144

Insulin signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

145

JAK-STAT signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

146

JAK-STAT signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

147

JAK-STAT signaling pathway 💬

[1] PRL 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

148

Lipid and atherosclerosis 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

149

Lipid and atherosclerosis 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

150

Long-term depression 💬

[1] CRHR1 💬

Corticorelin 💬

[1] 75 💬

151

Long-term depression 💬

[1] CRHR1 💬

[1] 75 💬

152

Longevity regulating pathway 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

153

Longevity regulating pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

154

Longevity regulating pathway - multiple species 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

155

Longevity regulating pathway - multiple species 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

156

MAPK signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

157

MAPK signaling pathway 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

158

Melanoma 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

159

Melanoma 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

160

[3] CYP11A1, CYP11B1, CYP17A1 💬

[1] 75 💬

161

[1] CYP11B1 💬

Metyrapone 💬

[1] 75 💬

162

[1] CYP11B2 💬

Osilodrostat 💬

Osilodrostat

[1] 75 💬

163

[1] CYP17A1 💬

Ketoconazole 💬

[3] 8 , 13, 75 💬

164

[1] PDE5A 💬

Tadalafil 💬

Tadalafil

[7] 6 , 51, 75, 84, 86, 113, 210 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

165

MicroRNAs in cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

166

MicroRNAs in cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

167

MicroRNAs in cancer 💬

[4] HDAC1, HDAC2, HDAC4, HDAC5 💬

Vorinostat 💬

[2] 75, 96 💬

168

Morphine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Alprazolam 💬

[2] 8 , 75 💬

169

Morphine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

170

mTOR signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

171

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

172

[1] AVPR2 💬

Desmopressin 💬

[6] 6 , 64, 72, 75, 225, 288 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
64	Thrombotic thrombocytopenic purpura;TTP;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
75	Cushing disease;Cushing;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;

173

[2] CRHR1, CRHR2 💬

Corticorelin 💬

[1] 75 💬

174

[2] CRHR1, CRHR2 💬

[1] 75 💬

175

[2] DRD2, PRL 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

176

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

177

[1] F2 💬

[2] 51, 75 💬

178

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Alprazolam 💬

[2] 8 , 75 💬

179

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

180

[1] GLP1R 💬

Liraglutide 💬

Liraglutide

[3] 6 , 75, 193 💬

181

[1] MC2R 💬

[12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
84	Sarcoidosis;
145	West syndrome;Infantile spasm;
222	Primary nephrotic syndrome;

182

[1] NR3C1 💬

Hydrocortisone 💬

Name	Other Names
Hydrocortisone	Hydrocortisone (JP18/USP/INN) HC Acticort (TN) Anusol HC (TN) Colocort (TN) Cortef (TN) Hytone (TN) Plenadren (TN) ALKINDI CORTENEMA ALA-SCALP ALACORT ANUSOL HYDROCORTISONE RECTAL SUSPENSION PROCTO-MED HC PROCTOCORT PROCTOSOL-HC PROCTOZONE PROCTOZONE-HC TEXACORT

Hydrocortisone

[10] 6 , 41, 46, 53, 75, 78, 81, 83, 97, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
75	Cushing disease;Cushing;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
83	Addison disease;Primary chronic adrenocortical insufficiency;
97	Ulcerative colitis;
299	Cystic fibrosis;

183

[1] NR3C1 💬

Mifepristone 💬

[1] 75 💬

184

[1] NR3C1 💬

Prednisolone 💬

Prednisolone

[42] 3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
35	Pemphigus;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
64	Thrombotic thrombocytopenic purpura;TTP;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
145	West syndrome;Infantile spasm;
162	Pemphigoid;
222	Primary nephrotic syndrome;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
296	Biliary atresia;
299	Cystic fibrosis;
300	IgG4-related disease;

185

[1] NR3C1 💬

Relacorilant 💬

Relacorilant

[1] 75 💬

186

[4] SSTR1, SSTR2, SSTR3, SSTR5 💬

Pasireotide 💬

[3] 67, 74, 75 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

187

[1] SSTR2 💬

Octreotide 💬

[7] 67, 75, 84, 85, 89, 193, 227 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
193	Prader-Willi syndrome;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;

188

Neutrophil extracellular trap formation 💬

[11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬

Name	Full Name
HDAC1	histone deacetylase 1
HDAC10	histone deacetylase 10
HDAC11	histone deacetylase 11
HDAC2	histone deacetylase 2
HDAC3	histone deacetylase 3
HDAC4	histone deacetylase 4
HDAC5	histone deacetylase 5
HDAC6	histone deacetylase 6
HDAC7	histone deacetylase 7
HDAC8	histone deacetylase 8
HDAC9	histone deacetylase 9

Vorinostat 💬

[2] 75, 96 💬

189

Nicotine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Alprazolam 💬

[2] 8 , 75 💬

190

Nicotine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

191

Non-alcoholic fatty liver disease 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

192

Non-alcoholic fatty liver disease 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

193

Non-alcoholic fatty liver disease 💬

[1] RXRA 💬

Bexarotene 💬

[2] 13, 75 💬

194

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

195

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

196

[1] RARB 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

197

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

198

Notch signaling pathway 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

199

Oocyte meiosis 💬

[1] PGR 💬

Mifepristone 💬

[1] 75 💬

200

Osteoclast differentiation 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

201

Ovarian steroidogenesis 💬

[2] CYP11A1, CYP17A1 💬

[1] 75 💬

202

Ovarian steroidogenesis 💬

[1] CYP17A1 💬

Ketoconazole 💬

[3] 8 , 13, 75 💬

203

Oxytocin signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

204

Oxytocin signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

205

Oxytocin signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

206

Pancreatic cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

207

Pancreatic cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

208

Parathyroid hormone synthesis, secretion and action 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

209

Parathyroid hormone synthesis, secretion and action 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

210

Parathyroid hormone synthesis, secretion and action 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

211

Parkinson disease 💬

[1] DRD2 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

212

Pathogenic Escherichia coli infection 💬

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

213

Pathogenic Escherichia coli infection 💬

[1] F2 💬

[2] 51, 75 💬

214

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

215

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

216

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

217

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

218

[1] F2 💬

[2] 51, 75 💬

219

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

220

[3] PML, RARA, RARB 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

221

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

222

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

PD-L1 expression and PD-1 checkpoint pathway in cancer 💬

[2] 13, 75 💬

223

[1] EGFR 💬

Gefitinib 💬

PD-L1 expression and PD-1 checkpoint pathway in cancer 💬

[1] 75 💬

224

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

225

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

226

[1] AVPR2 💬

Desmopressin 💬

[6] 6 , 64, 72, 75, 225, 288 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
64	Thrombotic thrombocytopenic purpura;TTP;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
75	Cushing disease;Cushing;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;

227

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

228

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

229

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

230

[1] F2 💬

[2] 51, 75 💬

231

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

232

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

233

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

234

[1] PRL 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

235

[1] RXRA 💬

Bexarotene 💬

[2] 13, 75 💬

236

Platelet activation 💬

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

237

Platelet activation 💬

[1] F2 💬

[2] 51, 75 💬

238

Platinum drug resistance 💬

[1] ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

239

PPAR signaling pathway 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

240

PPAR signaling pathway 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

241

Progesterone-mediated oocyte maturation 💬

[1] PGR 💬

Mifepristone 💬

[1] 75 💬

242

Prolactin signaling pathway 💬

[1] CYP17A1 💬

Ketoconazole 💬

[3] 8 , 13, 75 💬

243

Prolactin signaling pathway 💬

[1] CYP17A1 💬

[1] 75 💬

244

Prolactin signaling pathway 💬

[1] PRL 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

245

Prostate cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

246

Prostate cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

247

Protein digestion and absorption 💬

[1] DPP4 💬

Sitagliptin 💬

Sitagliptin

[4] 6 , 75, 233, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
75	Cushing disease;Cushing;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
299	Cystic fibrosis;

248

Proteoglycans in cancer 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

249

Proteoglycans in cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

250

Purine metabolism 💬

[1] PDE5A 💬

Tadalafil 💬

Tadalafil

[7] 6 , 51, 75, 84, 86, 113, 210 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

251

Rap1 signaling pathway 💬

[1] DRD2 💬

Cabergoline 💬

[3] 6 , 74, 75 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

252

Rap1 signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

253

Rap1 signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

254

Ras signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

255

Ras signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

256

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

257

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

258

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

259

[1] F2 💬

[2] 51, 75 💬

260

Relaxin signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

261

Relaxin signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

262

Renin secretion 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

263

Renin-angiotensin system 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

264

Retrograde endocannabinoid signaling 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Alprazolam 💬

[2] 8 , 75 💬

265

Retrograde endocannabinoid signaling 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

266

Serotonergic synapse 💬

[3] GABRB1, GABRB2, GABRB3 💬

Alprazolam 💬

[2] 8 , 75 💬

267

Serotonergic synapse 💬

[3] GABRB1, GABRB2, GABRB3 💬

Propofol 💬

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

268

Shigellosis 💬

[1] EGFR 💬

Gefitinib 💬

[1] 75 💬

269

Shigellosis 💬

[1] EGFR 💬

Lapatinib 💬

[3] 34, 74, 75 💬

270

Small cell lung cancer 💬

[1] RARB 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

271

Small cell lung cancer 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

272

[3] CYP11A1, CYP11B1, CYP17A1 💬

[1] 75 💬

273

[1] CYP11B1 💬

Metyrapone 💬

[1] 75 💬

274

[1] CYP11B2 💬

Osilodrostat 💬

Osilodrostat

[1] 75 💬

275

[1] CYP17A1 💬

Ketoconazole 💬

[3] 8 , 13, 75 💬

276

Taste transduction 💬

[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6

Alprazolam 💬

[2] 8 , 75 💬

277

Taste transduction 💬

[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6

Propofol 💬

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

278

Th17 cell differentiation 💬

[1] RARA 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

279

Th17 cell differentiation 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

280

Thermogenesis 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

281

Thermogenesis 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

282

Thyroid cancer 💬

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

283

Thyroid cancer 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

284

Thyroid hormone signaling pathway 💬

[3] HDAC1, HDAC2, HDAC3 💬

Vorinostat 💬

[2] 75, 96 💬

285

Thyroid hormone signaling pathway 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

286

Tight junction 💬

[1] ERBB2 💬

Lapatinib 💬

[3] 34, 74, 75 💬

287

Tight junction 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

288

[2] HDAC1, HDAC2 💬

Vorinostat 💬

[2] 75, 96 💬

289

[2] PML, RARA 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

290

[1] PPARG 💬

[5] 46, 75, 97, 222, 265 💬

291

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

[2] 13, 75 💬

292

Ubiquitin mediated proteolysis 💬

[1] PML 💬

Tretinoin 💬

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

293

Vascular smooth muscle contraction 💬

[1] AGTR1 💬

Valsartan 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

294

Vasopressin-regulated water reabsorption 💬

[1] AVPR2 💬

Desmopressin 💬

[6] 6 , 64, 72, 75, 225, 288 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
64	Thrombotic thrombocytopenic purpura;TTP;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
75	Cushing disease;Cushing;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;

295

Viral carcinogenesis 💬

[11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬

Name	Full Name
HDAC1	histone deacetylase 1
HDAC10	histone deacetylase 10
HDAC11	histone deacetylase 11
HDAC2	histone deacetylase 2
HDAC3	histone deacetylase 3
HDAC4	histone deacetylase 4
HDAC5	histone deacetylase 5
HDAC6	histone deacetylase 6
HDAC7	histone deacetylase 7
HDAC8	histone deacetylase 8
HDAC9	histone deacetylase 9

Vorinostat 💬