Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Acute myeloid leukemia 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
2 AMPK signaling pathway 💬
 [1] HMGCR 💬 Atorvastatin 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
3 Axon guidance 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
4 Bile secretion 💬
 [1] HMGCR 💬 Atorvastatin 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
5 Biosynthesis of cofactors 💬
 [2] NQO1, VKORC1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
6 Breast cancer 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
7 Calcium signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
8 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
9 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
10 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
11 Calcium signaling pathway 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
12 cAMP signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
13 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
14 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
15 cAMP signaling pathway 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
16 Cell cycle 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
17 Central carbon metabolism in cancer 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
18 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
19 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
20 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
21 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
22 cGMP-PKG signaling pathway 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
23 Chemical carcinogenesis - reactive oxygen species 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
24 Chemical carcinogenesis - reactive oxygen species 💬
 [1] NQO1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
25 Choline metabolism in cancer 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
26 Chronic myeloid leukemia 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
27 Circadian entrainment 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
28 Complement and coagulation cascades 💬
 [1] F10 💬 Edoxaban 💬 Edoxaban [2] 46, 88 💬
29 EGFR tyrosine kinase inhibitor resistance 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
30 Endocytosis 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
31 ErbB signaling pathway 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
32 Fluid shear stress and atherosclerosis 💬
 [1] NQO1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
33 Focal adhesion 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
34 Gap junction 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
35 Gap junction 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
36 Glioma 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
37 Hematopoietic cell lineage 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
38 Hepatocellular carcinoma 💬
 [1] NQO1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
39 Human cytomegalovirus infection 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
40 JAK-STAT signaling pathway 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
41 Long-term depression 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
42 MAPK signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
43 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
44 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
45 Melanogenesis 💬
 [1] EDNRB 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
46 Melanogenesis 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
47 Melanoma 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
48 Metabolic pathways 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
49 Metabolic pathways 💬
 [1] HMGCR 💬 Atorvastatin 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
50 Metabolic pathways 💬
 [2] NQO1, VKORC1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
51 MicroRNAs in cancer 💬
 [2] ABL1, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
52 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
53 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
54 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
55 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
56 Neuroactive ligand-receptor interaction 💬
 [1] PTGIR 💬 Selexipag 💬 Selexipag [5] 51, 70, 84, 86, 88 💬
57 Neuroactive ligand-receptor interaction 💬
 [1] PTGIR 💬 Treprostinil 💬 Treprostinil [6] 51, 84, 85, 86, 88, 210 💬
58 Neurotrophin signaling pathway 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
59 Oxytocin signaling pathway 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
60 Pathogenic Escherichia coli infection 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
61 Pathways in cancer 💬
 [3] ABL1, KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
62 Pathways in cancer 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
63 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
64 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
65 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
66 Pathways in cancer 💬
 [1] NQO1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
67 Phospholipase D signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
68 PI3K-Akt signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
69 Platelet activation 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
70 Platelet activation 💬
 [1] PTGIR 💬 Selexipag 💬 Selexipag [5] 51, 70, 84, 86, 88 💬
71 Platelet activation 💬
 [1] PTGIR 💬 Treprostinil 💬 Treprostinil [6] 51, 84, 85, 86, 88, 210 💬
72 Prostate cancer 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
73 Purine metabolism 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
74 Rap1 signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
75 Ras signaling pathway 💬
 [3] ABL1, KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
76 Regulation of actin cytoskeleton 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
77 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
78 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
79 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
80 Renin secretion 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
81 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
82 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
83 Renin secretion 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
84 Renin secretion 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
85 Salivary secretion 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
86 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 Atorvastatin 💬 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
87 Ubiquinone and other terpenoid-quinone biosynthesis 💬
 [2] NQO1, VKORC1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
88 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
89 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
90 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
91 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
92 Vascular smooth muscle contraction 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
93 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Selexipag 💬 Selexipag [5] 51, 70, 84, 86, 88 💬
94 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Treprostinil 💬 Treprostinil [6] 51, 84, 85, 86, 88, 210 💬
95 Viral myocarditis 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

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