Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alzheimer disease 💬
 [1] ADAM17 💬 Apratastat 💬 Apratastat [1] 46 💬
2 Alzheimer disease 💬
 [4] APH1A, NCSTN, PSEN1, PSENEN 💬 Tarenflurbil 💬 Tarenflurbil [1] 13 💬
3 Alzheimer disease 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
4 Alzheimer disease 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
5 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
6 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
7 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
8 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
9 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
10 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
11 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
12 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
13 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
14 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
15 Alzheimer disease 💬
 [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM3, CHRM5 💬 Propiverine 💬 Propiverine [1] 226 💬
16 Alzheimer disease 💬
 [1] CASP9 💬 Rimiducid 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
17 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Atropine 💬 Atropine [2]  2 , 299 💬
18 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Blarcamesine 💬 Blarcamesine [1] 156 💬
19 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
20 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Oxybutynin 💬 Oxybutynin [3]  6 , 13, 53 💬
21 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Scopolamine 💬 Scopolamine [1]  2  💬
22 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Trihexyphenidyl 💬 Trihexyphenidyl [2]  5 ,  6  💬
23 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Tropicamide 💬 Tropicamide [1]  6  💬
24 Alzheimer disease 💬
 [1] CHRM3 💬 Cevimeline 💬 Cevimeline [1] 53 💬
25 Alzheimer disease 💬
 [1] CHRM3 💬 Darifenacin 💬 Darifenacin [2]  6 , 13 💬
26 Alzheimer disease 💬
 [1] CHRM3 💬 Fesoterodine 💬 Fesoterodine [1]  6  💬
27 Alzheimer disease 💬
 [1] CHRM3 💬 Pilocarpine 💬 Pilocarpine [3]  6 , 53, 299 💬
28 Alzheimer disease 💬
 [1] CHRM3 💬 Solifenacin 💬 Solifenacin [3]  6 , 13, 53 💬
29 Alzheimer disease 💬
 [1] CHRM3 💬 Tolterodine 💬 Tolterodine [2] 17, 53 💬
30 Alzheimer disease 💬
 [1] CHRNA7 💬 Nicotine 💬 Nicotine [3]  6 , 13, 84 💬
31 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Acamprosate 💬 Acamprosate [2]  6 , 206 💬
32 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amantadine 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
33 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
34 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine [3]  2 ,  4 , 70 💬
35 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Ketamine 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
36 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Latrepirdine 💬 Latrepirdine [1]  8  💬
37 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
38 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
39 Alzheimer disease 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬
40 Alzheimer disease 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
41 Alzheimer disease 💬
 [4] IL1A, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
42 Alzheimer disease 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
43 Alzheimer disease 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
44 Alzheimer disease 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
45 Alzheimer disease 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
46 Alzheimer disease 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
47 Alzheimer disease 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
48 Alzheimer disease 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
49 Alzheimer disease 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
50 Alzheimer disease 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [2] 96, 156 💬
51 Alzheimer disease 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
52 Alzheimer disease 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
53 Alzheimer disease 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
54 Alzheimer disease 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
55 Alzheimer disease 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
56 Alzheimer disease 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
57 Alzheimer disease 💬
 [1] MAPT 💬 Flortaucipir F 18 💬 Flortaucipir [3]  5 ,  7 , 127 💬
58 Alzheimer disease 💬
 [1] MAPT 💬 Gosuranemab 💬 Gosuranemab [1]  5  💬
59 Alzheimer disease 💬
 [1] MAPT 💬 Hydromethylthionine mesylate 💬 Hydromethylthionine mesylate [1] 127 💬
60 Alzheimer disease 💬
 [1] MME 💬 Sacubitril 💬 Sacubitril [2] 58, 222 💬
61 Alzheimer disease 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
62 Alzheimer disease 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
63 Alzheimer disease 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
64 Alzheimer disease 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
65 Alzheimer disease 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
66 Alzheimer disease 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
67 Alzheimer disease 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
68 Alzheimer disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
69 Alzheimer disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬
70 Alzheimer disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
71 Alzheimer disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
72 Alzheimer disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬
73 Alzheimer disease 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬
74 Alzheimer disease 💬
 [1] PSMB5 💬 Carfilzomib 💬 Carfilzomib [1] 28 💬
75 Alzheimer disease 💬
 [1] PSMB5 💬 Ixazomib 💬 Ixazomib [5] 13, 16, 28, 51, 61 💬
76 Alzheimer disease 💬
 [1] PTGS2 💬 Aceclofenac 💬 Aceclofenac [1] 46 💬
77 Alzheimer disease 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
78 Alzheimer disease 💬
 [1] PTGS2 💬 Aspirin 💬 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
79 Alzheimer disease 💬
 [1] PTGS2 💬 Celecoxib 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
80 Alzheimer disease 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
81 Alzheimer disease 💬
 [1] PTGS2 💬 Diflunisal 💬 Diflunisal [1] 28 💬
82 Alzheimer disease 💬
 [1] PTGS2 💬 Etodolac 💬 Etodolac [1] 46 💬
83 Alzheimer disease 💬
 [1] PTGS2 💬 Etoricoxib 💬 Etoricoxib [2] 46, 271 💬
84 Alzheimer disease 💬
 [1] PTGS2 💬 Flurbiprofen 💬 Flurbiprofen [3] 13, 21, 46 💬
85 Alzheimer disease 💬
 [1] PTGS2 💬 Ibuprofen 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
86 Alzheimer disease 💬
 [1] PTGS2 💬 Indomethacin 💬 Indomethacin [3] 225, 271, 298 💬
87 Alzheimer disease 💬
 [1] PTGS2 💬 Ketoprofen 💬 Ketoprofen [1] 46 💬
88 Alzheimer disease 💬
 [1] PTGS2 💬 Ketorolac 💬 Ketorolac [2] 70, 226 💬
89 Alzheimer disease 💬
 [1] PTGS2 💬 Loxoprofen 💬 Loxoprofen [2] 46, 271 💬
90 Alzheimer disease 💬
 [1] PTGS2 💬 Lumiracoxib 💬 Lumiracoxib [1] 46 💬
91 Alzheimer disease 💬
 [1] PTGS2 💬 Meloxicam 💬 Meloxicam [4] 46, 49, 271, 296 💬
92 Alzheimer disease 💬
 [1] PTGS2 💬 Naproxen 💬 Naproxen [4] 13, 46, 107, 271 💬
93 Alzheimer disease 💬
 [1] PTGS2 💬 Nimesulide 💬 Nimesulide [1] 46 💬
94 Alzheimer disease 💬
 [1] PTGS2 💬 Parecoxib 💬 Parecoxib [2] 46, 271 💬
95 Alzheimer disease 💬
 [1] PTGS2 💬 Rofecoxib 💬 Rofecoxib [1] 46 💬
96 Alzheimer disease 💬
 [1] PTGS2 💬 Salsalate 💬 Salsalate [1]  5  💬
97 Alzheimer disease 💬
 [1] PTGS2 💬 Sulindac 💬 Sulindac [1] 206 💬
98 Alzheimer disease 💬
 [1] PTGS2 💬 Tolfenamic acid 💬 Tolfenamic acid [1]  5  💬
99 Alzheimer disease 💬
 [1] PTGS2 💬 Valdecoxib 💬 Valdecoxib [1] 46 💬
100 Alzheimer disease 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
101 Alzheimer disease 💬
 [1] RTN4 💬 Ozanezumab 💬 Ozanezumab [1]  2  💬
102 Alzheimer disease 💬
 [1] SNCA 💬 Prasinezumab 💬 Prasinezumab [1]  6  💬
103 Alzheimer disease 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
104 Alzheimer disease 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
105 Alzheimer disease 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
106 Alzheimer disease 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
107 Alzheimer disease 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
108 Alzheimer disease 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
109 Alzheimer disease 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
110 Alzheimer disease 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
111 Alzheimer disease 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
112 Alzheimer disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Belantamab mafodotin 💬 Belantamab mafodotin [1] 28 💬
113 Alzheimer disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Brentuximab vedotin 💬 Brentuximab vedotin [2] 49, 51 💬
114 Alzheimer disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Colchicine 💬 Colchicine [7]  2 , 42, 46, 56, 93, 210, 266 💬
115 Alzheimer disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Paclitaxel 💬 Paclitaxel [2] 46, 85 💬
116 Alzheimer disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vinblastine 💬 Vinblastine [2] 34, 65 💬
117 Alzheimer disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vincristine 💬 Vincristine [4] 26, 34, 65, 331 💬