Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Breast cancer 💬

[1] BRAF 💬

Dabrafenib 💬

Dabrafenib

[1] 34 💬

Breast cancer 💬

[4] BRAF, FLT4, KIT, RAF1 💬

Name	Full Name
BRAF	B-Raf proto-oncogene, serine/threonine kinase
FLT4	fms related receptor tyrosine kinase 4
KIT	KIT proto-oncogene, receptor tyrosine kinase
RAF1	Raf-1 proto-oncogene, serine/threonine kinase

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

Breast cancer 💬

[2] CDK4, CDK6 💬

Abemaciclib 💬

Abemaciclib

[1] 34 💬

Breast cancer 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

Breast cancer 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

Breast cancer 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

Breast cancer 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

Breast cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

Breast cancer 💬

[2] EGFR, ERBB2 💬

Neratinib 💬

Neratinib

[1] 34 💬

Breast cancer 💬

[3] EGFR, ERBB2, FLT4 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

Breast cancer 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Clomifene 💬

Clomifene

[1] 74 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Estradiol 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

Estradiol

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

Breast cancer 💬

[2] ESR1, ESR2 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Estriol 💬

Estriol

[2] 13, 227 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Estriol tripropionate 💬

Estriol

[2] 13, 227 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Fulvestrant 💬

Fulvestrant

[2] 49, 86 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Mestranol 💬

Mestranol

[2] 46, 49 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Prasterone 💬

Prasterone

[6] 49, 53, 83, 86, 96, 113 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;

Breast cancer 💬

[2] ESR1, ESR2 💬

Raloxifene 💬

Raloxifene

[1] 46 💬

Breast cancer 💬

[2] ESR1, ESR2 💬

Tamoxifen 💬

Tamoxifen

[3] 2 , 113, 227 💬

Breast cancer 💬

[2] ESR1, PGR 💬

Danazol 💬

Danazol

[5] 60, 63, 64, 65, 285 💬

Breast cancer 💬

[2] ESR1, PGR 💬

Desogestrel 💬

Desogestrel

[1] 230 💬

Breast cancer 💬

[1] FGF23 💬

Burosumab 💬

Burosumab

[1] 238 💬

Breast cancer 💬

[1] FGFR1 💬

Infigratinib 💬

Infigratinib

[1] 276 💬

Breast cancer 💬

[2] FGFR1, FLT4 💬

Nintedanib 💬

Nintedanib

[5] 51, 85, 89, 227, 228 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Breast cancer 💬

[1] FLT4 💬

Axitinib 💬

Axitinib

[1] 34 💬

Breast cancer 💬

[1] FLT4 💬

Cediranib 💬

Cediranib

[1] 34 💬

Breast cancer 💬

[2] FLT4, KIT 💬

Sunitinib 💬

Sunitinib

[2] 28, 34 💬

Breast cancer 💬

[1] IGF1R 💬

Linsitinib 💬

Linsitinib

[1] 232 💬

Breast cancer 💬

[1] IGF1R 💬

Mecasermin 💬

Mecasermin

[6] 65, 78, 96, 168, 265, 299 💬

Breast cancer 💬

[1] IGF1R 💬

Teprotumumab 💬

Teprotumumab

[1] 51 💬

Breast cancer 💬

[1] KIT 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Breast cancer 💬

[1] KIT 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Breast cancer 💬

[1] KIT 💬

Imatinib 💬

Imatinib

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

Breast cancer 💬

[1] KIT 💬

Masitinib 💬

Masitinib

[6] 2 , 5 , 6 , 13, 46, 96 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
96	Crohn disease;Terminal ileitis;

Breast cancer 💬

[1] KIT 💬

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

Breast cancer 💬

[1] KIT 💬

Pexidartinib 💬

Pexidartinib

[1] 34 💬

Breast cancer 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

Breast cancer 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

Breast cancer 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

Breast cancer 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

Breast cancer 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Breast cancer 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

Breast cancer 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Breast cancer 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

Breast cancer 💬

[1] PGR 💬

Dydrogesterone 💬

Dydrogesterone

[1] 13 💬

Breast cancer 💬

[1] PGR 💬

Levonorgestrel 💬

Levonorgestrel

[1] 13 💬

Breast cancer 💬

[1] PGR 💬

Medroxyprogesterone acetate 💬

Medroxyprogesterone acetate

[8] 13, 35, 46, 49, 50, 51, 60, 107 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
107	Juvenile idiopathic arthritis;JIA;

Breast cancer 💬

[1] PGR 💬

Megestrol acetate 💬

Megestrol acetate

[1] 76 💬

Breast cancer 💬

[1] PGR 💬

Mifepristone 💬

Mifepristone

[1] 75 💬

Breast cancer 💬

[1] PGR 💬

Nomegestrol 💬

Nomegestrol

[1] 13 💬

Breast cancer 💬

[1] PGR 💬

Nomegestrol acetate 💬

Nomegestrol acetate

[1] 13 💬

Breast cancer 💬

[1] PGR 💬

Norethindrone 💬

Norethisterone

[4] 13, 46, 49, 299 💬

Breast cancer 💬

[1] PGR 💬

Norgestimate 💬

Norgestimate

[1] 299 💬

Breast cancer 💬

[1] PGR 💬

Progesterone 💬

Progesterone

[2] 76, 299 💬

Breast cancer 💬

[1] PGR 💬

Ulipristal 💬

Ulipristal

[1] 10 💬

Breast cancer 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

Breast cancer 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Breast cancer 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Breast cancer 💬

[1] TNFSF11 💬

Denosumab 💬

Denosumab

[8] 46, 50, 70, 93, 95, 96, 274, 299 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
70	Spinal stenosis;Extensive spinal canal stenosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
274	Osteogenesis Imperfecta;
299	Cystic fibrosis;