Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Chemical carcinogenesis - reactive oxygen species 💬
 [1] ABL1 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
2 Chemical carcinogenesis - reactive oxygen species 💬
 [1] ABL1 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
3 Chemical carcinogenesis - reactive oxygen species 💬
 [2] ABL1, SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
4 Chemical carcinogenesis - reactive oxygen species 💬
 [2] ABL1, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
5 Chemical carcinogenesis - reactive oxygen species 💬
 [2] ABL1, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
6 Chemical carcinogenesis - reactive oxygen species 💬
 [2] ABL1, SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
7 Chemical carcinogenesis - reactive oxygen species 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
8 Chemical carcinogenesis - reactive oxygen species 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
9 Chemical carcinogenesis - reactive oxygen species 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
10 Chemical carcinogenesis - reactive oxygen species 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
11 Chemical carcinogenesis - reactive oxygen species 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
12 Chemical carcinogenesis - reactive oxygen species 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
13 Chemical carcinogenesis - reactive oxygen species 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
14 Chemical carcinogenesis - reactive oxygen species 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
15 Chemical carcinogenesis - reactive oxygen species 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
16 Chemical carcinogenesis - reactive oxygen species 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
17 Chemical carcinogenesis - reactive oxygen species 💬
 [1] KEAP1 💬 Dimethyl fumarate 💬 Dimethyl fumarate [5] 13, 49, 51, 86, 296 💬
18 Chemical carcinogenesis - reactive oxygen species 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
19 Chemical carcinogenesis - reactive oxygen species 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
20 Chemical carcinogenesis - reactive oxygen species 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
21 Chemical carcinogenesis - reactive oxygen species 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
22 Chemical carcinogenesis - reactive oxygen species 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
23 Chemical carcinogenesis - reactive oxygen species 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
24 Chemical carcinogenesis - reactive oxygen species 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
25 Chemical carcinogenesis - reactive oxygen species 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
26 Chemical carcinogenesis - reactive oxygen species 💬
 [1] MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
27 Chemical carcinogenesis - reactive oxygen species 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
28 Chemical carcinogenesis - reactive oxygen species 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
29 Chemical carcinogenesis - reactive oxygen species 💬
 [1] NQO1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
30 Chemical carcinogenesis - reactive oxygen species 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
31 Chemical carcinogenesis - reactive oxygen species 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
32 Chemical carcinogenesis - reactive oxygen species 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
33 Chemical carcinogenesis - reactive oxygen species 💬
 [1] PRKCD 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
34 Chemical carcinogenesis - reactive oxygen species 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
35 Chemical carcinogenesis - reactive oxygen species 💬
 [1] SOD1 💬 Tofersen 💬 Tofersen [1]  2  💬
36 Chemical carcinogenesis - reactive oxygen species 💬
 [1] VEGFA 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
37 Chemical carcinogenesis - reactive oxygen species 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
38 Chemical carcinogenesis - reactive oxygen species 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬