Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Diabetic cardiomyopathy 💬

[1] ACE 💬

Benazepril 💬

Benazepril

[4] 49, 57, 218, 224 💬

Diabetic cardiomyopathy 💬

[1] ACE 💬

Captopril 💬

Captopril

[8] 6 , 17, 46, 86, 96, 97, 107, 271 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Diabetic cardiomyopathy 💬

[1] ACE 💬

Cilazapril 💬

Cilazapril

[1] 66 💬

Diabetic cardiomyopathy 💬

[1] ACE 💬

Cilazapril 💬

Cilazapril

[1] 66 💬

Diabetic cardiomyopathy 💬

[1] ACE 💬

Enalapril 💬

Enalapril

[6] 19, 46, 66, 113, 210, 222 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
222	Primary nephrotic syndrome;

Diabetic cardiomyopathy 💬

[1] ACE 💬

Imidapril 💬

Imidapril

[1] 67 💬

Diabetic cardiomyopathy 💬

[1] ACE 💬

Lisinopril 💬

Lisinopril

[7] 19, 46, 49, 66, 67, 113, 222 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
113	Muscular dystrophy;
222	Primary nephrotic syndrome;

Diabetic cardiomyopathy 💬

[1] ACE 💬

Lisinopril 💬

Lisinopril

[7] 19, 46, 49, 66, 67, 113, 222 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
113	Muscular dystrophy;
222	Primary nephrotic syndrome;

Diabetic cardiomyopathy 💬

[1] ACE 💬

Moexipril 💬

Moexipril

[1] 93 💬

Diabetic cardiomyopathy 💬

[1] ACE 💬

Perindopril 💬

Perindopril

[4] 58, 113, 167, 222 💬

Diabetic cardiomyopathy 💬

[1] ACE 💬

Quinapril 💬

Quinapril

[1] 19 💬

Diabetic cardiomyopathy 💬

[1] ACE 💬

Ramipril 💬

Ramipril

[7] 46, 49, 66, 67, 113, 218, 257 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
113	Muscular dystrophy;
218	Alport syndrome;
257	Hepatic glycogenosis;Liver glycogenosis;Hepatic glycogen storage disease;Liver glycogen storage disease;

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Candesartan 💬

Candesartan

[2] 58, 67 💬

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Candesartan cilexetil 💬

Candesartan cilexetil

[1] 67 💬

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Irbesartan 💬

Irbesartan

[4] 66, 167, 168, 222 💬

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Losartan 💬

Losartan

[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
36	Epidermolysis bullosa;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
167	Marfan syndrome;
179	Williams syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Sparsentan 💬

Sparsentan

[3] 66, 218, 222 💬

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Telmisartan 💬

Telmisartan

[2] 66, 67 💬

Diabetic cardiomyopathy 💬

[1] AGTR1 💬

Valsartan 💬

Valsartan

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Diabetic cardiomyopathy 💬

[2] CPT1B, CPT2 💬

Perhexiline 💬

Perhexiline

[2] 58, 272 💬

Diabetic cardiomyopathy 💬

[1] INSR 💬

Insulin detemir 💬

Insulin detemir

[1] 299 💬

Diabetic cardiomyopathy 💬

[1] INSR 💬

Insulin glargine 💬

Name	Other Names
Insulin glargine	Insulin glargine (USAN/INN) Insulin glargine (genetical recombination) (JP18) Insulin glargine (genetical recombination) [Insulin glargin biosimilar 1] (JAN) Insulin glargine (genetical recombination) [Insulin glargin biosimilar 2] (JAN) Lantus (TN) BASAGLAR INSULIN GLARGINE SOLOSTAR LANTUS SOLOSTAR REZVOGLAR SEMGLEE TOUJEO TOUJEO MAX

Insulin glargine

[1] 299 💬

Diabetic cardiomyopathy 💬

[1] INSR 💬

Insulin human 💬

Insulin human

[2] 96, 156 💬

Diabetic cardiomyopathy 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

Diabetic cardiomyopathy 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

Diabetic cardiomyopathy 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

Diabetic cardiomyopathy 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Diabetic cardiomyopathy 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

Diabetic cardiomyopathy 💬

[1] NFKB1 💬

Iguratimod 💬

Iguratimod

[5] 46, 51, 53, 271, 300 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

Diabetic cardiomyopathy 💬

[1] PARP1 💬

Olaparib 💬

Olaparib

[2] 86, 285 💬

Diabetic cardiomyopathy 💬

[3] PDK2, PDK3, PDK4 💬

Sodium dichloroacetate 💬

Sodium dichloroacetate

[1] 86 💬

Diabetic cardiomyopathy 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

Diabetic cardiomyopathy 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Diabetic cardiomyopathy 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Diabetic cardiomyopathy 💬

[1] PPARA 💬

Bezafibrate 💬

Bezafibrate

[7] 20, 93, 94, 160, 296, 316, 324 💬

Disease ID	Name
20	Adrenoleukodystrophy;ALD;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
94	Primary sclerosing cholangitis;PSC;
160	Congenital ichthyosis;
296	Biliary atresia;
316	Carnitine cycle disorder;
324	Methylglutaconic aciduria;

Diabetic cardiomyopathy 💬

[1] PPARA 💬

Elafibranor 💬

Elafibranor

[2] 93, 94 💬

Diabetic cardiomyopathy 💬

[1] PPARA 💬

Fenofibrate 💬

Fenofibrate

[6] 8 , 79, 93, 94, 97, 265 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
79	Homozygous familial hypercholesterolemia;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
94	Primary sclerosing cholangitis;PSC;
97	Ulcerative colitis;
265	Lipodystrophy;