Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Estrogen signaling pathway 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
2 Estrogen signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
3 Estrogen signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
4 Estrogen signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
5 Estrogen signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
6 Estrogen signaling pathway 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
7 Estrogen signaling pathway 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
8 Estrogen signaling pathway 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
9 Estrogen signaling pathway 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
10 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
11 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
12 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
13 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
14 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
15 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
16 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
17 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
18 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
19 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
20 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
21 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
22 Estrogen signaling pathway 💬
 [2] ESR1, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
23 Estrogen signaling pathway 💬
 [2] ESR1, PGR 💬 Desogestrel 💬 Desogestrel [1] 230 💬
24 Estrogen signaling pathway 💬
 [2] GABBR1, GABBR2 💬 Arbaclofen 💬 Arbaclofen [2] 13, 206 💬
25 Estrogen signaling pathway 💬
 [2] GABBR1, GABBR2 💬 Arbaclofen placarbil 💬 Arbaclofen Placarbil [1] 13 💬
26 Estrogen signaling pathway 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
27 Estrogen signaling pathway 💬
 [2] GABBR1, GABBR2 💬 Valiloxybate 💬 Valiloxybate [1]  6  💬
28 Estrogen signaling pathway 💬
 [2] KCNJ3, KCNJ5 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
29 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
30 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
31 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
32 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
33 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
34 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Buprenorphine 💬 Buprenorphine [2] 46, 70 💬
35 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Dezocine 💬 Dezocine [1] 46 💬
36 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Dihydrocodeine 💬 Dihydrocodeine [1] 310 💬
37 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Fentanyl 💬 Fentanyl [3] 46, 70, 215 💬
38 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Hydromorphone 💬 Hydromorphone [1] 70 💬
39 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Loperamide 💬 Loperamide [2] 13, 97 💬
40 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Morphine 💬 Morphine [5] 36, 46, 70, 85, 86 💬
41 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Nalbuphine 💬 Nalbuphine [1] 85 💬
42 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Nalmefene 💬 Nalmefene [1]  6  💬
43 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Naloxone 💬 Naloxone [2]  6 , 226 💬
44 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Naltrexone 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
45 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Oxycodone 💬 Oxycodone [5]  6 , 13, 70, 226, 298 💬
46 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Oxymorphone 💬 Oxymorphone [1] 70 💬
47 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Remifentanil 💬 Remifentanil [2]  6 , 70 💬
48 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Sufentanil 💬 Sufentanil [2] 70, 280 💬
49 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Tramadol 💬 Tramadol [5] 46, 70, 78, 226, 271 💬
50 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Trimebutine 💬 Trimebutine [1] 51 💬
51 Estrogen signaling pathway 💬
 [1] PGR 💬 Dydrogesterone 💬 Dydrogesterone [1] 13 💬
52 Estrogen signaling pathway 💬
 [1] PGR 💬 Levonorgestrel 💬 Levonorgestrel [1] 13 💬
53 Estrogen signaling pathway 💬
 [1] PGR 💬 Medroxyprogesterone acetate 💬 Medroxyprogesterone acetate [8] 13, 35, 46, 49, 50, 51, 60, 107 💬
54 Estrogen signaling pathway 💬
 [1] PGR 💬 Megestrol acetate 💬 Megestrol acetate [1] 76 💬
55 Estrogen signaling pathway 💬
 [1] PGR 💬 Mifepristone 💬 Mifepristone [1] 75 💬
56 Estrogen signaling pathway 💬
 [1] PGR 💬 Nomegestrol 💬 Nomegestrol [1] 13 💬
57 Estrogen signaling pathway 💬
 [1] PGR 💬 Nomegestrol acetate 💬 Nomegestrol acetate [1] 13 💬
58 Estrogen signaling pathway 💬
 [1] PGR 💬 Norethindrone 💬 Norethisterone [4] 13, 46, 49, 299 💬
59 Estrogen signaling pathway 💬
 [1] PGR 💬 Norgestimate 💬 Norgestimate [1] 299 💬
60 Estrogen signaling pathway 💬
 [1] PGR 💬 Progesterone 💬 Progesterone [2] 76, 299 💬
61 Estrogen signaling pathway 💬
 [1] PGR 💬 Ulipristal 💬 Ulipristal [1] 10 💬
62 Estrogen signaling pathway 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
63 Estrogen signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
64 Estrogen signaling pathway 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
65 Estrogen signaling pathway 💬
 [1] PRKCD 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
66 Estrogen signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
67 Estrogen signaling pathway 💬
 [1] RARA 💬 Acitretin 💬 Acitretin [1] 37 💬
68 Estrogen signaling pathway 💬
 [1] RARA 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬
69 Estrogen signaling pathway 💬
 [1] RARA 💬 Fenretinide 💬 Fenretinide [1] 299 💬
70 Estrogen signaling pathway 💬
 [1] RARA 💬 Isotretinoin 💬 Isotretinoin [4] 36, 39, 159, 160 💬
71 Estrogen signaling pathway 💬
 [1] RARA 💬 Tamibarotene 💬 Tamibarotene [2] 26, 96 💬
72 Estrogen signaling pathway 💬
 [1] RARA 💬 Tretinoin 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
73 Estrogen signaling pathway 💬
 [1] RARA 💬 Vitamin A 💬 Vitamin A [3] 13, 53, 90 💬
74 Estrogen signaling pathway 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
75 Estrogen signaling pathway 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
76 Estrogen signaling pathway 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
77 Estrogen signaling pathway 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬