Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Fluid shear stress and atherosclerosis 💬
 [1] ACVR2A 💬 Sotatercept 💬 Sotatercept [2] 86, 284 💬
2 Fluid shear stress and atherosclerosis 💬
 [2] ACVR2A, ACVR2B 💬 Bimagrumab 💬 Bimagrumab [1] 15 💬
3 Fluid shear stress and atherosclerosis 💬
 [1] ACVR2B 💬 Luspatercept 💬 Luspatercept [1] 60 💬
4 Fluid shear stress and atherosclerosis 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
5 Fluid shear stress and atherosclerosis 💬
 [4] CCL2, IL1A, IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
6 Fluid shear stress and atherosclerosis 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
7 Fluid shear stress and atherosclerosis 💬
 [1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬
8 Fluid shear stress and atherosclerosis 💬
 [1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬
9 Fluid shear stress and atherosclerosis 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬
10 Fluid shear stress and atherosclerosis 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
11 Fluid shear stress and atherosclerosis 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
12 Fluid shear stress and atherosclerosis 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
13 Fluid shear stress and atherosclerosis 💬
 [2] IL1R1, IL1R2 💬 Anakinra 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
14 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
15 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
16 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
17 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
18 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
19 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
20 Fluid shear stress and atherosclerosis 💬
 [1] KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
21 Fluid shear stress and atherosclerosis 💬
 [1] KEAP1 💬 Dimethyl fumarate 💬 Dimethyl fumarate [5] 13, 49, 51, 86, 296 💬
22 Fluid shear stress and atherosclerosis 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
23 Fluid shear stress and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
24 Fluid shear stress and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
25 Fluid shear stress and atherosclerosis 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
26 Fluid shear stress and atherosclerosis 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
27 Fluid shear stress and atherosclerosis 💬
 [1] NQO1 💬 Warfarin 💬 Warfarin [11]  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
28 Fluid shear stress and atherosclerosis 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
29 Fluid shear stress and atherosclerosis 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
30 Fluid shear stress and atherosclerosis 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
31 Fluid shear stress and atherosclerosis 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
32 Fluid shear stress and atherosclerosis 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
33 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
34 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
35 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
36 Fluid shear stress and atherosclerosis 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
37 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
38 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
39 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
40 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
41 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
42 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
43 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
44 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
45 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
46 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
47 Fluid shear stress and atherosclerosis 💬
 [1] VEGFA 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
48 Fluid shear stress and atherosclerosis 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
49 Fluid shear stress and atherosclerosis 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬