Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Human immunodeficiency virus 1 infection 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
2 Human immunodeficiency virus 1 infection 💬
 [1] CASP9 💬 Rimiducid 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
3 Human immunodeficiency virus 1 infection 💬
 [1] CCR5 💬 Cenicriviroc 💬 Cenicriviroc [1] 94 💬
4 Human immunodeficiency virus 1 infection 💬
 [1] CCR5 💬 Maraviroc 💬 Maraviroc [2] 46, 84 💬
5 Human immunodeficiency virus 1 infection 💬
 [3] CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab [1] 46 💬
6 Human immunodeficiency virus 1 infection 💬
 [3] CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab [2] 96, 97 💬
7 Human immunodeficiency virus 1 infection 💬
 [1] CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab [1] 49 💬
8 Human immunodeficiency virus 1 infection 💬
 [1] CD4 💬 Zanolimumab 💬 Zanolimumab [1] 46 💬
9 Human immunodeficiency virus 1 infection 💬
 [1] CXCR4 💬 Plerixafor 💬 Plerixafor [5] 19, 20, 65, 285, 299 💬
10 Human immunodeficiency virus 1 infection 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Rontalizumab 💬 Rontalizumab [1] 49 💬
11 Human immunodeficiency virus 1 infection 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Sifalimumab 💬 Sifalimumab [1] 49 💬
12 Human immunodeficiency virus 1 infection 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
13 Human immunodeficiency virus 1 infection 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
14 Human immunodeficiency virus 1 infection 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
15 Human immunodeficiency virus 1 infection 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
16 Human immunodeficiency virus 1 infection 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
17 Human immunodeficiency virus 1 infection 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
18 Human immunodeficiency virus 1 infection 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
19 Human immunodeficiency virus 1 infection 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
20 Human immunodeficiency virus 1 infection 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
21 Human immunodeficiency virus 1 infection 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
22 Human immunodeficiency virus 1 infection 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
23 Human immunodeficiency virus 1 infection 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
24 Human immunodeficiency virus 1 infection 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
25 Human immunodeficiency virus 1 infection 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
26 Human immunodeficiency virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
27 Human immunodeficiency virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬
28 Human immunodeficiency virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
29 Human immunodeficiency virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
30 Human immunodeficiency virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬
31 Human immunodeficiency virus 1 infection 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
32 Human immunodeficiency virus 1 infection 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
33 Human immunodeficiency virus 1 infection 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
34 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
35 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
36 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
37 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
38 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
39 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
40 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
41 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
42 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
43 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
44 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬