Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬
2 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Captopril 💬 Captopril [8]  6 , 17, 46, 86, 96, 97, 107, 271 💬
3 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Cilazapril 💬 Cilazapril [1] 66 💬
4 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Cilazapril 💬 Cilazapril [1] 66 💬
5 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Enalapril 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
6 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Imidapril 💬 Imidapril [1] 67 💬
7 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Lisinopril 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
8 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Lisinopril 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
9 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Moexipril 💬 Moexipril [1] 93 💬
10 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
11 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Quinapril 💬 Quinapril [1] 19 💬
12 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬
13 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
14 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
15 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
16 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
17 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
18 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
19 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
20 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
21 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
22 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
23 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
24 Hypertrophic cardiomyopathy 💬
 [2] CACNA2D1, CACNA2D2 💬 Mirogabalin 💬 Mirogabalin [1] 70 💬
25 Hypertrophic cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Gabapentin 💬 Gabapentin [5]  6 , 13, 19, 70, 298 💬
26 Hypertrophic cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Pregabalin 💬 Pregabalin [5] 13, 36, 46, 70, 298 💬
27 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 Casimersen 💬 Casimersen [1] 113 💬
28 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 Drisapersen 💬 Drisapersen [1] 113 💬
29 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 Eteplirsen 💬 Eteplirsen [1] 113 💬
30 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 Golodirsen 💬 Golodirsen [1] 113 💬
31 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 Viltolarsen 💬 Viltolarsen [1] 113 💬
32 Hypertrophic cardiomyopathy 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
33 Hypertrophic cardiomyopathy 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
34 Hypertrophic cardiomyopathy 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
35 Hypertrophic cardiomyopathy 💬
 [2] IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
36 Hypertrophic cardiomyopathy 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
37 Hypertrophic cardiomyopathy 💬
 [1] ITGA4 💬 Firategrast 💬 Firategrast [1] 13 💬
38 Hypertrophic cardiomyopathy 💬
 [1] ITGA4 💬 Natalizumab 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
39 Hypertrophic cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 Abrilumab 💬 Abrilumab [2] 96, 97 💬
40 Hypertrophic cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 Vedolizumab 💬 Vedolizumab [3] 94, 96, 97 💬
41 Hypertrophic cardiomyopathy 💬
 [1] ITGB7 💬 Etrolizumab 💬 Etrolizumab [2] 96, 97 💬
42 Hypertrophic cardiomyopathy 💬
 [1] MYH7 💬 Mavacamten 💬 Mavacamten [1] 58 💬
43 Hypertrophic cardiomyopathy 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
44 Hypertrophic cardiomyopathy 💬
 [3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬
45 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
46 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
47 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
48 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
49 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
50 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
51 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
52 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
53 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬