Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Morphine addiction 💬
 [1] ADORA1 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
2 Morphine addiction 💬
 [1] ADORA1 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
3 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
4 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
5 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
6 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
7 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
8 Morphine addiction 💬
 [1] CACNA1B 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
9 Morphine addiction 💬
 [1] DRD1 💬 Apomorphine 💬 Apomorphine [3]  5 ,  6 ,  7  💬
10 Morphine addiction 💬
 [1] DRD1 💬 Dexpramipexole 💬 Dexpramipexole [1]  2  💬
11 Morphine addiction 💬
 [1] DRD1 💬 Dopamine 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
12 Morphine addiction 💬
 [1] DRD1 💬 Flupentixol 💬 Flupentixol [1] 97 💬
13 Morphine addiction 💬
 [1] DRD1 💬 Foslevodopa 💬 Foslevodopa [1]  6  💬
14 Morphine addiction 💬
 [1] DRD1 💬 Levodopa 💬 Levodopa [6]  6 , 17, 90, 140, 164, 201 💬
15 Morphine addiction 💬
 [1] DRD1 💬 Pergolide 💬 Pergolide [1]  6  💬
16 Morphine addiction 💬
 [1] DRD1 💬 Tavapadon 💬 Tavapadon [1]  6  💬
17 Morphine addiction 💬
 [2] GABBR1, GABBR2 💬 Arbaclofen 💬 Arbaclofen [2] 13, 206 💬
18 Morphine addiction 💬
 [2] GABBR1, GABBR2 💬 Arbaclofen placarbil 💬 Arbaclofen Placarbil [1] 13 💬
19 Morphine addiction 💬
 [2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
20 Morphine addiction 💬
 [2] GABBR1, GABBR2 💬 Valiloxybate 💬 Valiloxybate [1]  6  💬
21 Morphine addiction 💬
 [1] GABRA1 💬 Etomidate 💬 Etomidate [1]  6  💬
22 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Alprazolam 💬 Alprazolam [2]  8 , 75 💬
23 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Brexanolone 💬 Brexanolone [1] 205 💬
24 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬
25 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clonazepam 💬 Clonazepam [1]  6  💬
26 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Delorazepam 💬 Delorazepam [3]  6 , 46, 97 💬
27 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Diazepam 💬 Diazepam [3] 46, 155, 298 💬
28 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Eszopiclone 💬 Eszopiclone [3]  6 , 13, 46 💬
29 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
30 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Gaboxadol 💬 Gaboxadol [2] 201, 206 💬
31 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
32 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Lorazepam 💬 Lorazepam [1] 36 💬
33 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Midazolam 💬 Midazolam [12]  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
34 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Propofol 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
35 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
36 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Zolpidem 💬 Zolpidem [3]  5 ,  6 , 46 💬
37 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Zopiclone 💬 Zopiclone [1]  6  💬
38 Morphine addiction 💬
 [2] KCNJ3, KCNJ5 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
39 Morphine addiction 💬
 [1] OPRM1 💬 Buprenorphine 💬 Buprenorphine [2] 46, 70 💬
40 Morphine addiction 💬
 [1] OPRM1 💬 Dezocine 💬 Dezocine [1] 46 💬
41 Morphine addiction 💬
 [1] OPRM1 💬 Dihydrocodeine 💬 Dihydrocodeine [1] 310 💬
42 Morphine addiction 💬
 [1] OPRM1 💬 Fentanyl 💬 Fentanyl [3] 46, 70, 215 💬
43 Morphine addiction 💬
 [1] OPRM1 💬 Hydromorphone 💬 Hydromorphone [1] 70 💬
44 Morphine addiction 💬
 [1] OPRM1 💬 Loperamide 💬 Loperamide [2] 13, 97 💬
45 Morphine addiction 💬
 [1] OPRM1 💬 Morphine 💬 Morphine [5] 36, 46, 70, 85, 86 💬
46 Morphine addiction 💬
 [1] OPRM1 💬 Nalbuphine 💬 Nalbuphine [1] 85 💬
47 Morphine addiction 💬
 [1] OPRM1 💬 Nalmefene 💬 Nalmefene [1]  6  💬
48 Morphine addiction 💬
 [1] OPRM1 💬 Naloxone 💬 Naloxone [2]  6 , 226 💬
49 Morphine addiction 💬
 [1] OPRM1 💬 Naltrexone 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
50 Morphine addiction 💬
 [1] OPRM1 💬 Oxycodone 💬 Oxycodone [5]  6 , 13, 70, 226, 298 💬
51 Morphine addiction 💬
 [1] OPRM1 💬 Oxymorphone 💬 Oxymorphone [1] 70 💬
52 Morphine addiction 💬
 [1] OPRM1 💬 Remifentanil 💬 Remifentanil [2]  6 , 70 💬
53 Morphine addiction 💬
 [1] OPRM1 💬 Sufentanil 💬 Sufentanil [2] 70, 280 💬
54 Morphine addiction 💬
 [1] OPRM1 💬 Tramadol 💬 Tramadol [5] 46, 70, 78, 226, 271 💬
55 Morphine addiction 💬
 [1] OPRM1 💬 Trimebutine 💬 Trimebutine [1] 51 💬
56 Morphine addiction 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
57 Morphine addiction 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
58 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
59 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
60 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
61 Morphine addiction 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
62 Morphine addiction 💬
 [1] PDE4A 💬 Dipyridamole 💬 Dipyridamole [6] 46, 49, 51, 66, 96, 224 💬
63 Morphine addiction 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Apremilast 💬 Apremilast [7] 46, 50, 56, 97, 107, 162, 271 💬
64 Morphine addiction 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Roflumilast 💬 Roflumilast [4] 84, 97, 206, 299 💬
65 Morphine addiction 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Rolipram 💬 Rolipram [2]  8 , 13 💬
66 Morphine addiction 💬
 [1] PDE4D 💬 Zatolmilast 💬 Zatolmilast [1] 206 💬
67 Morphine addiction 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬