Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Parkinson disease 💬
 [1] ADORA2A 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
2 Parkinson disease 💬
 [1] ADORA2A 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
3 Parkinson disease 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
4 Parkinson disease 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
5 Parkinson disease 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
6 Parkinson disease 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
7 Parkinson disease 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
8 Parkinson disease 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
9 Parkinson disease 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
10 Parkinson disease 💬
 [1] CASP9 💬 Rimiducid 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
11 Parkinson disease 💬
 [1] DRD1 💬 Tavapadon 💬 Tavapadon [1]  6  💬
12 Parkinson disease 💬
 [2] DRD1, DRD2 💬 Apomorphine 💬 Apomorphine [3]  5 ,  6 ,  7  💬
13 Parkinson disease 💬
 [2] DRD1, DRD2 💬 Dexpramipexole 💬 Dexpramipexole [1]  2  💬
14 Parkinson disease 💬
 [2] DRD1, DRD2 💬 Dopamine 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
15 Parkinson disease 💬
 [2] DRD1, DRD2 💬 Flupentixol 💬 Flupentixol [1] 97 💬
16 Parkinson disease 💬
 [2] DRD1, DRD2 💬 Foslevodopa 💬 Foslevodopa [1]  6  💬
17 Parkinson disease 💬
 [2] DRD1, DRD2 💬 Levodopa 💬 Levodopa [6]  6 , 17, 90, 140, 164, 201 💬
18 Parkinson disease 💬
 [2] DRD1, DRD2 💬 Pergolide 💬 Pergolide [1]  6  💬
19 Parkinson disease 💬
 [1] DRD2 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
20 Parkinson disease 💬
 [1] DRD2 💬 Bromocriptine 💬 Bromocriptine [2]  6 , 74 💬
21 Parkinson disease 💬
 [1] DRD2 💬 Buspirone 💬 Buspirone [2]  6 , 51 💬
22 Parkinson disease 💬
 [1] DRD2 💬 Cabergoline 💬 Cabergoline [3]  6 , 74, 75 💬
23 Parkinson disease 💬
 [1] DRD2 💬 Cariprazine 💬 Cariprazine [1] 21 💬
24 Parkinson disease 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
25 Parkinson disease 💬
 [1] DRD2 💬 Domperidone 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬
26 Parkinson disease 💬
 [1] DRD2 💬 Domperidone maleate 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬
27 Parkinson disease 💬
 [1] DRD2 💬 Haloperidol 💬 Haloperidol [1]  8  💬
28 Parkinson disease 💬
 [1] DRD2 💬 Iloperidone 💬 Iloperidone [1]  6  💬
29 Parkinson disease 💬
 [1] DRD2 💬 Lisuride 💬 Lisuride [2]  6 , 86 💬
30 Parkinson disease 💬
 [1] DRD2 💬 Melperone 💬 Melperone [1]  6  💬
31 Parkinson disease 💬
 [1] DRD2 💬 Metoclopramide 💬 Metoclopramide [2] 46, 51 💬
32 Parkinson disease 💬
 [1] DRD2 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
33 Parkinson disease 💬
 [1] DRD2 💬 Pardoprunox 💬 Pardoprunox [1]  6  💬
34 Parkinson disease 💬
 [1] DRD2 💬 Pimozide 💬 Pimozide [1]  2  💬
35 Parkinson disease 💬
 [1] DRD2 💬 Piribedil 💬 Piribedil [1]  6  💬
36 Parkinson disease 💬
 [1] DRD2 💬 Pramipexole 💬 Pramipexole [3]  2 ,  6 , 20 💬
37 Parkinson disease 💬
 [1] DRD2 💬 Pridopidine 💬 Pridopidine [3]  2 ,  6 ,  8  💬
38 Parkinson disease 💬
 [1] DRD2 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
39 Parkinson disease 💬
 [1] DRD2 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
40 Parkinson disease 💬
 [1] DRD2 💬 Ropinirole 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
41 Parkinson disease 💬
 [1] DRD2 💬 Rotigotine 💬 Rotigotine [1]  6  💬
42 Parkinson disease 💬
 [1] DRD2 💬 Sulpiride 💬 Sulpiride [2]  6 , 70 💬
43 Parkinson disease 💬
 [1] DRD2 💬 Terguride 💬 Terguride [2] 51, 86 💬
44 Parkinson disease 💬
 [1] DRD2 💬 Tiapride 💬 Tiapride [1]  8  💬
45 Parkinson disease 💬
 [1] DRD2 💬 Trifluoperazine maleate 💬 Trifluoperazine [2] 283, 284 💬
46 Parkinson disease 💬
 [1] DRD2 💬 Trifluoperazine 💬 Trifluoperazine [2] 283, 284 💬
47 Parkinson disease 💬
 [1] KEAP1 💬 Dimethyl fumarate 💬 Dimethyl fumarate [5] 13, 49, 51, 86, 296 💬
48 Parkinson disease 💬
 [1] MAOA 💬 Moclobemide 💬 Moclobemide [1]  6  💬
49 Parkinson disease 💬
 [2] MAOA, MAOB 💬 Iproniazid 💬 Iproniazid [1]  6  💬
50 Parkinson disease 💬
 [2] MAOA, MAOB 💬 Phenelzine 💬 Phenelzine [1]  6  💬
51 Parkinson disease 💬
 [3] MAOA, MAOB, SLC6A3 💬 Phentermine 💬 Phentermine [1] 97 💬
52 Parkinson disease 💬
 [1] MAOB 💬 Rasagiline 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
53 Parkinson disease 💬
 [1] MAOB 💬 Rasagiline tartrate 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
54 Parkinson disease 💬
 [1] MAOB 💬 Safinamide 💬 Safinamide [2]  6 , 17 💬
55 Parkinson disease 💬
 [1] MAOB 💬 Selegiline 💬 Selegiline [1]  6  💬
56 Parkinson disease 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
57 Parkinson disease 💬
 [1] MAPT 💬 Flortaucipir F 18 💬 Flortaucipir [3]  5 ,  7 , 127 💬
58 Parkinson disease 💬
 [1] MAPT 💬 Gosuranemab 💬 Gosuranemab [1]  5  💬
59 Parkinson disease 💬
 [1] MAPT 💬 Hydromethylthionine mesylate 💬 Hydromethylthionine mesylate [1] 127 💬
60 Parkinson disease 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬
61 Parkinson disease 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬
62 Parkinson disease 💬
 [1] PSMB5 💬 Carfilzomib 💬 Carfilzomib [1] 28 💬
63 Parkinson disease 💬
 [1] PSMB5 💬 Ixazomib 💬 Ixazomib [5] 13, 16, 28, 51, 61 💬
64 Parkinson disease 💬
 [1] SLC18A2 💬 Deutetrabenazine 💬 Deutetrabenazine [1]  8  💬
65 Parkinson disease 💬
 [1] SLC18A2 💬 Tetrabenazine 💬 Tetrabenazine [1]  8  💬
66 Parkinson disease 💬
 [1] SLC18A2 💬 Valbenazine 💬 Valbenazine [1]  8  💬
67 Parkinson disease 💬
 [1] SLC6A3 💬 Armodafinil 💬 Armodafinil [3]  6 , 13, 84 💬
68 Parkinson disease 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
69 Parkinson disease 💬
 [1] SLC6A3 💬 Lisdexamfetamine 💬 Lisdexamfetamine [1] 13 💬
70 Parkinson disease 💬
 [1] SLC6A3 💬 Methylphenidate 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
71 Parkinson disease 💬
 [1] SNCA 💬 Prasinezumab 💬 Prasinezumab [1]  6  💬
72 Parkinson disease 💬
 [1] SOD1 💬 Tofersen 💬 Tofersen [1]  2  💬
73 Parkinson disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Belantamab mafodotin 💬 Belantamab mafodotin [1] 28 💬
74 Parkinson disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Brentuximab vedotin 💬 Brentuximab vedotin [2] 49, 51 💬
75 Parkinson disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Colchicine 💬 Colchicine [7]  2 , 42, 46, 56, 93, 210, 266 💬
76 Parkinson disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Paclitaxel 💬 Paclitaxel [2] 46, 85 💬
77 Parkinson disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vinblastine 💬 Vinblastine [2] 34, 65 💬
78 Parkinson disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vincristine 💬 Vincristine [4] 26, 34, 65, 331 💬