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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Thyroid hormone signaling pathway 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digitoxin 💬

Digitoxin

[1] 299 💬

Thyroid hormone signaling pathway 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Thyroid hormone signaling pathway 💬

[1] CASP9 💬

Rimiducid 💬

Rimiducid

[6] 19, 60, 65, 284, 285, 326 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Clomifene 💬

Clomifene

[1] 74 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Danazol 💬

Danazol

[5] 60, 63, 64, 65, 285 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Desogestrel 💬

Desogestrel

[1] 230 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Estetrol 💬

Estetrol

[1] 53 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Estetrol 💬

Estetrol

[1] 53 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Estradiol 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

Estradiol

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Estriol 💬

Estriol

[2] 13, 227 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Estriol tripropionate 💬

Estriol

[2] 13, 227 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Fulvestrant 💬

Fulvestrant

[2] 49, 86 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Mestranol 💬

Mestranol

[2] 46, 49 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Prasterone 💬

Prasterone

[6] 49, 53, 83, 86, 96, 113 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Raloxifene 💬

Raloxifene

[1] 46 💬

Thyroid hormone signaling pathway 💬

[1] ESR1 💬

Tamoxifen 💬

Tamoxifen

[3] 2 , 113, 227 💬

Thyroid hormone signaling pathway 💬

[3] HDAC1, HDAC2, HDAC3 💬

Vorinostat 💬

Vorinostat

[2] 75, 96 💬

Thyroid hormone signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

Thyroid hormone signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

Thyroid hormone signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

Thyroid hormone signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

Thyroid hormone signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Thyroid hormone signaling pathway 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

Thyroid hormone signaling pathway 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Thyroid hormone signaling pathway 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

Thyroid hormone signaling pathway 💬

[1] MYH7 💬

Mavacamten 💬

Mavacamten

[1] 58 💬

Thyroid hormone signaling pathway 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

Thyroid hormone signaling pathway 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Thyroid hormone signaling pathway 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Thyroid hormone signaling pathway 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Thyroid hormone signaling pathway 💬

[1] RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

Thyroid hormone signaling pathway 💬

[3] RXRA, RXRB, RXRG 💬

Acitretin 💬

Acitretin

[1] 37 💬

Thyroid hormone signaling pathway 💬

[3] RXRA, RXRB, RXRG 💬

Alitretinoin 💬

Alitretinoin

[1] 49 💬

Thyroid hormone signaling pathway 💬

[3] RXRA, RXRB, RXRG 💬

Bexarotene 💬

Bexarotene

[2] 13, 75 💬

Thyroid hormone signaling pathway 💬

[1] SRC 💬

Bosutinib 💬

Bosutinib

[2] 2 , 67 💬

Thyroid hormone signaling pathway 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Thyroid hormone signaling pathway 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Thyroid hormone signaling pathway 💬

[1] SRC 💬

Saracatinib 💬

Saracatinib

[3] 6 , 89, 272 💬

Thyroid hormone signaling pathway 💬

[2] THRA, THRB 💬

Levothyroxine 💬

Levothyroxine

[5] 19, 49, 78, 80, 222 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
49	Systemic lupus erythematosus;SLE;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
80	Resistance to thyroid hormone;Syndrome of resistance to thyroid hormone;Thyroid hormone insensitivity syndrome;Refetoff syndrome;RTH;
222	Primary nephrotic syndrome;

Thyroid hormone signaling pathway 💬

[2] THRA, THRB 💬

Liothyronine 💬

Liothyronine

[4] 13, 78, 210, 212 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
212	Tricuspid atresia;TA;

Thyroid hormone signaling pathway 💬

[2] THRA, THRB 💬

Tiratricol 💬

Tiratricol

[2] 78, 139 💬

Thyroid hormone signaling pathway 💬

[1] THRB 💬

Sobetirome 💬

Sobetirome

[1] 20 💬