Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Toll-like receptor signaling pathway 💬
 [1] CD40 💬 Bleselumab 💬 Bleselumab [1] 222 💬
2 Toll-like receptor signaling pathway 💬
 [1] CD40 💬 Iscalimab 💬 Iscalimab [2] 49, 53 💬
3 Toll-like receptor signaling pathway 💬
 [1] CD40 💬 Ravagalimab 💬 Ravagalimab [2] 53, 97 💬
4 Toll-like receptor signaling pathway 💬
 [2] CD80, CD86 💬 Abatacept 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
5 Toll-like receptor signaling pathway 💬
 [2] CD80, CD86 💬 Belatacept 💬 Belatacept [1] 46 💬
6 Toll-like receptor signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Rontalizumab 💬 Rontalizumab [1] 49 💬
7 Toll-like receptor signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Sifalimumab 💬 Sifalimumab [1] 49 💬
8 Toll-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab [3] 46, 49, 53 💬
9 Toll-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
10 Toll-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a [1] 56 💬
11 Toll-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b [2] 25, 34 💬
12 Toll-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
13 Toll-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b [1] 13 💬
14 Toll-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a [1] 13 💬
15 Toll-like receptor signaling pathway 💬
 [2] IL12A, IL12B 💬 Ustekinumab 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
16 Toll-like receptor signaling pathway 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
17 Toll-like receptor signaling pathway 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
18 Toll-like receptor signaling pathway 💬
 [1] IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
19 Toll-like receptor signaling pathway 💬
 [3] IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
20 Toll-like receptor signaling pathway 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
21 Toll-like receptor signaling pathway 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
22 Toll-like receptor signaling pathway 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
23 Toll-like receptor signaling pathway 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
24 Toll-like receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
25 Toll-like receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
26 Toll-like receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
27 Toll-like receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
28 Toll-like receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
29 Toll-like receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
30 Toll-like receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
31 Toll-like receptor signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
32 Toll-like receptor signaling pathway 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
33 Toll-like receptor signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
34 Toll-like receptor signaling pathway 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
35 Toll-like receptor signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
36 Toll-like receptor signaling pathway 💬
 [1] TLR7 💬 Imiquimod 💬 Imiquimod [2] 34, 51 💬
37 Toll-like receptor signaling pathway 💬
 [1] TLR9 💬 Cobitolimod 💬 Cobitolimod [1] 97 💬
38 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
39 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
40 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
41 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
42 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
43 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
44 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
45 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
46 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬