Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [8] ADRA1A, ADRA1B, ADRA1D, HRH1, HTR2A, HTR2B, HTR2C, HTR6 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
2 Calcium signaling pathway 💬
 [8] CHRM1, CHRM2, CHRM3, CHRM5, HRH1, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
3 Calcium signaling pathway 💬
 [1] HTR2A 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
4 Calcium signaling pathway 💬
 [1] HTR2A 💬 Cariprazine 💬 Cariprazine [1] 21 💬
5 Calcium signaling pathway 💬
 [1] HTR2A 💬 Nelotanserin 💬 Nelotanserin [1]  6  💬
6 Calcium signaling pathway 💬
 [1] HTR2A 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
7 Calcium signaling pathway 💬
 [1] HTR2A 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
8 Calcium signaling pathway 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Iloperidone 💬 Iloperidone [1]  6  💬
9 Calcium signaling pathway 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Trazodone 💬 Trazodone [1]  2  💬
10 Calcium signaling pathway 💬
 [2] HTR2A, HTR2C 💬 Clozapine 💬 Clozapine [1]  6  💬
11 Calcium signaling pathway 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
12 Calcium signaling pathway 💬
 [2] HTR2A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬
13 Calcium signaling pathway 💬
 [2] HTR2A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬
14 Gap junction 💬
 [2] DRD2, HTR2A 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
15 Gap junction 💬
 [2] DRD2, HTR2A 💬 Cariprazine 💬 Cariprazine [1] 21 💬
16 Gap junction 💬
 [2] DRD2, HTR2A 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
17 Gap junction 💬
 [2] DRD2, HTR2A 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
18 Gap junction 💬
 [4] DRD2, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
19 Gap junction 💬
 [4] DRD2, HTR2A, HTR2B, HTR2C 💬 Iloperidone 💬 Iloperidone [1]  6  💬
20 Gap junction 💬
 [4] DRD2, HTR2A, HTR2B, HTR2C 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
21 Gap junction 💬
 [1] HTR2A 💬 Cisapride 💬 Cisapride [1] 13 💬
22 Gap junction 💬
 [1] HTR2A 💬 Cisapride 💬 Cisapride [1] 13 💬
23 Gap junction 💬
 [1] HTR2A 💬 Nelotanserin 💬 Nelotanserin [1]  6  💬
24 Gap junction 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Trazodone 💬 Trazodone [1]  2  💬
25 Gap junction 💬
 [2] HTR2A, HTR2C 💬 Clozapine 💬 Clozapine [1]  6  💬
26 Gap junction 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
27 Inflammatory mediator regulation of TRP channels 💬
 [4] HRH1, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
28 Inflammatory mediator regulation of TRP channels 💬
 [4] HRH1, HTR2A, HTR2B, HTR2C 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
29 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
30 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 Cariprazine 💬 Cariprazine [1] 21 💬
31 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 Cisapride 💬 Cisapride [1] 13 💬
32 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 Cisapride 💬 Cisapride [1] 13 💬
33 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 Nelotanserin 💬 Nelotanserin [1]  6  💬
34 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
35 Inflammatory mediator regulation of TRP channels 💬
 [1] HTR2A 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
36 Inflammatory mediator regulation of TRP channels 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Iloperidone 💬 Iloperidone [1]  6  💬
37 Inflammatory mediator regulation of TRP channels 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Trazodone 💬 Trazodone [1]  2  💬
38 Inflammatory mediator regulation of TRP channels 💬
 [2] HTR2A, HTR2C 💬 Clozapine 💬 Clozapine [1]  6  💬
39 Inflammatory mediator regulation of TRP channels 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
40 Neuroactive ligand-receptor interaction 💬
 [11] ADRA1A, ADRA1B, ADRA1D, DRD2, DRD3, DRD4, HRH1, HTR2A, HTR2B, HTR2C, HTR6 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
41 Neuroactive ligand-receptor interaction 💬
 [13] ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
42 Neuroactive ligand-receptor interaction 💬
 [6] ADRA2A, ADRA2B, ADRA2C, DRD4, HTR2A, HTR2C 💬 Clozapine 💬 Clozapine [1]  6  💬
43 Neuroactive ligand-receptor interaction 💬
 [4] DRD2, DRD3, HTR1A, HTR2A 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
44 Neuroactive ligand-receptor interaction 💬
 [3] DRD2, HTR1A, HTR2A 💬 Cariprazine 💬 Cariprazine [1] 21 💬
45 Neuroactive ligand-receptor interaction 💬
 [2] DRD2, HTR2A 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
46 Neuroactive ligand-receptor interaction 💬
 [2] DRD2, HTR2A 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
47 Neuroactive ligand-receptor interaction 💬
 [4] DRD2, HTR2A, HTR2B, HTR2C 💬 Iloperidone 💬 Iloperidone [1]  6  💬
48 Neuroactive ligand-receptor interaction 💬
 [3] HTR1D, HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
49 Neuroactive ligand-receptor interaction 💬
 [1] HTR2A 💬 Nelotanserin 💬 Nelotanserin [1]  6  💬
50 Neuroactive ligand-receptor interaction 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Trazodone 💬 Trazodone [1]  2  💬
51 Neuroactive ligand-receptor interaction 💬
 [2] HTR2A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬
52 Neuroactive ligand-receptor interaction 💬
 [2] HTR2A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬
53 Serotonergic synapse 💬
 [2] HTR1A, HTR2A 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
54 Serotonergic synapse 💬
 [2] HTR1A, HTR2A 💬 Cariprazine 💬 Cariprazine [1] 21 💬
55 Serotonergic synapse 💬
 [4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
56 Serotonergic synapse 💬
 [1] HTR2A 💬 Nelotanserin 💬 Nelotanserin [1]  6  💬
57 Serotonergic synapse 💬
 [1] HTR2A 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
58 Serotonergic synapse 💬
 [1] HTR2A 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
59 Serotonergic synapse 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
60 Serotonergic synapse 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Iloperidone 💬 Iloperidone [1]  6  💬
61 Serotonergic synapse 💬
 [4] HTR2A, HTR2B, HTR2C, HTR6 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
62 Serotonergic synapse 💬
 [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 Trazodone 💬 Trazodone [1]  2  💬
63 Serotonergic synapse 💬
 [7] HTR2A, HTR2C, HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 Clozapine 💬 Clozapine [1]  6  💬
64 Serotonergic synapse 💬
 [3] HTR2A, HTR3A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬
65 Serotonergic synapse 💬
 [3] HTR2A, HTR3A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬

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