Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Acute myeloid leukemia 💬
 [4] BRAF, FLT3, KIT, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
2 Acute myeloid leukemia 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
3 Acute myeloid leukemia 💬
 [3] CSF1R, FLT3, KIT 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
4 Acute myeloid leukemia 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
5 Acute myeloid leukemia 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
6 Acute myeloid leukemia 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
7 Acute myeloid leukemia 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
8 Acute myeloid leukemia 💬
 [1] KIT 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
9 Breast cancer 💬
 [4] BRAF, FLT4, KIT, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
10 Breast cancer 💬
 [2] FLT4, KIT 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
11 Breast cancer 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
12 Breast cancer 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
13 Breast cancer 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
14 Breast cancer 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
15 Breast cancer 💬
 [1] KIT 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
16 Breast cancer 💬
 [1] KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
17 Central carbon metabolism in cancer 💬
 [2] FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
18 Central carbon metabolism in cancer 💬
 [5] FLT3, KIT, PDGFRA, PDGFRB, RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
19 Central carbon metabolism in cancer 💬
 [5] FLT3, KIT, PDGFRB, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
20 Central carbon metabolism in cancer 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
21 Central carbon metabolism in cancer 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
22 Central carbon metabolism in cancer 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
23 Central carbon metabolism in cancer 💬
 [2] KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
24 Central carbon metabolism in cancer 💬
 [2] KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
25 Hematopoietic cell lineage 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
26 Hematopoietic cell lineage 💬
 [3] CSF1R, FLT3, KIT 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
27 Hematopoietic cell lineage 💬
 [2] FLT3, KIT 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
28 Hematopoietic cell lineage 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
29 Hematopoietic cell lineage 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
30 Hematopoietic cell lineage 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
31 Hematopoietic cell lineage 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
32 Hematopoietic cell lineage 💬
 [1] KIT 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
33 MAPK signaling pathway 💬
 [7] BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
34 MAPK signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
35 MAPK signaling pathway 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
36 MAPK signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
37 MAPK signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
38 MAPK signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
39 MAPK signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
40 MAPK signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
41 Melanogenesis 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
42 Melanogenesis 💬
 [1] KIT 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
43 Melanogenesis 💬
 [1] KIT 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
44 Melanogenesis 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
45 Melanogenesis 💬
 [1] KIT 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
46 Melanogenesis 💬
 [1] KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
47 Melanogenesis 💬
 [1] KIT 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
48 Melanogenesis 💬
 [2] KIT, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
49 Pathways in cancer 💬
 [3] ABL1, KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
50 Pathways in cancer 💬
 [4] ABL1, KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
51 Pathways in cancer 💬
 [3] ABL1, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
52 Pathways in cancer 💬
 [3] ABL1, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
53 Pathways in cancer 💬
 [7] BRAF, FLT3, FLT4, KIT, PDGFRB, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
54 Pathways in cancer 💬
 [7] CSF1R, FLT3, FLT4, KIT, PDGFRA, PDGFRB, RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
55 Pathways in cancer 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
56 Pathways in cancer 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
57 Phospholipase D signaling pathway 💬
 [3] FYN, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
58 Phospholipase D signaling pathway 💬
 [3] FYN, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
59 Phospholipase D signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
60 Phospholipase D signaling pathway 💬
 [1] KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
61 Phospholipase D signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
62 Phospholipase D signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
63 Phospholipase D signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
64 Phospholipase D signaling pathway 💬
 [3] KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
65 PI3K-Akt signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
66 PI3K-Akt signaling pathway 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
67 PI3K-Akt signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
68 PI3K-Akt signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
69 PI3K-Akt signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
70 PI3K-Akt signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
71 PI3K-Akt signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
72 PI3K-Akt signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
73 Rap1 signaling pathway 💬
 [6] BRAF, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
74 Rap1 signaling pathway 💬
 [7] CSF1R, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
75 Rap1 signaling pathway 💬
 [2] CSF1R, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
76 Rap1 signaling pathway 💬
 [4] EPHA2, KIT, PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
77 Rap1 signaling pathway 💬
 [4] EPHA2, KIT, PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
78 Rap1 signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
79 Rap1 signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
80 Rap1 signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
81 Ras signaling pathway 💬
 [4] ABL1, EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
82 Ras signaling pathway 💬
 [4] ABL1, EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
83 Ras signaling pathway 💬
 [3] ABL1, KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
84 Ras signaling pathway 💬
 [4] ABL1, KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
85 Ras signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
86 Ras signaling pathway 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
87 Ras signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
88 Ras signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬

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