Target Gene/Pathway Pathway / Gene

[3] 245, 246, 251 💬

[1] ALOX5 💬

Oxatomide 💬

Oxatomide

[1] 113 💬

[1] ALOX5 💬

Zileuton 💬

Zileuton

[3] 85, 160, 164 💬

[3] PTGES, PTGS1, PTGS2 💬

Aceclofenac 💬

Aceclofenac

[1] 46 💬

[2] PTGS1, PTGS2 💬

Acetaminophen 💬

Acetaminophen

[15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
337	Homocystinuria;

[2] PTGS1, PTGS2 💬

Aspirin 💬

Acetylsalicylic acid

[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
64	Thrombotic thrombocytopenic purpura;TTP;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
158	Tuberous sclerosis;Tuberous sclerosis complex;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
231	Alpha-1-antitrypsin deficiency;AATD;
251	Urea cycle disorder;

[2] PTGS1, PTGS2 💬

Diclofenac 💬

Diclofenac

[5] 13, 34, 46, 78, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

[2] PTGS1, PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

[2] PTGS1, PTGS2 💬

Ibuprofen 💬

Ibuprofen

[7] 13, 46, 65, 107, 113, 271, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

[2] PTGS1, PTGS2 💬

Indomethacin 💬

Indomethacin

[3] 225, 271, 298 💬

Disease ID	Name
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
298	Hereditary pancreatitis;Chronic pancreatitis;

[2] PTGS1, PTGS2 💬

Ketoprofen 💬

Ketoprofen

[1] 46 💬

[2] PTGS1, PTGS2 💬

Ketorolac 💬

Ketorolac

[2] 70, 226 💬

[2] PTGS1, PTGS2 💬

Loxoprofen 💬

Loxoprofen

[2] 46, 271 💬

[2] PTGS1, PTGS2 💬

Naproxen 💬

Naproxen

[4] 13, 46, 107, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

[2] PTGS1, PTGS2 💬

Salsalate 💬

Salsalate

[1] 5 💬

[2] PTGS1, PTGS2 💬

Sulindac 💬

Sulindac

[1] 206 💬

[2] PTGS1, PTGS2 💬

Tolfenamic acid 💬

Tolfenamic acid

[1] 5 💬

[1] PTGS2 💬

Celecoxib 💬

Celecoxib

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

[1] PTGS2 💬

Diflunisal 💬

Diflunisal

[1] 28 💬

[1] PTGS2 💬

Etodolac 💬

Etodolac

[1] 46 💬

[1] PTGS2 💬

Etoricoxib 💬

Etoricoxib

[2] 46, 271 💬

[1] PTGS2 💬

Lumiracoxib 💬

Lumiracoxib

[1] 46 💬

[1] PTGS2 💬

Meloxicam 💬

Meloxicam

[4] 46, 49, 271, 296 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
296	Biliary atresia;

[1] PTGS2 💬

Nimesulide 💬

Nimesulide

[1] 46 💬

[1] PTGS2 💬

Parecoxib 💬

Parecoxib

[2] 46, 271 💬

[1] PTGS2 💬

Rofecoxib 💬

Rofecoxib

[1] 46 💬

[1] PTGS2 💬

Valdecoxib 💬

Valdecoxib

[1] 46 💬

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

[1] MAOB 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

[1] MAOB 💬

Safinamide 💬

[2] 6 , 17 💬

[1] MAOB 💬

Selegiline 💬

[1] 6 💬

[1] ODC1 💬

Eflornithine 💬

Eflornithine

[1] 65 💬

Ascorbate and aldarate metabolism 💬

[1] GUSB 💬

[1] 19 💬

Axon guidance 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

Bacterial invasion of epithelial cells 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

beta-Alanine metabolism 💬

[1] ABAT 💬

Vigabatrin 💬

[2] 145, 158 💬

beta-Alanine metabolism 💬

[3] ABAT, GAD1, GAD2 💬

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

beta-Alanine metabolism 💬

[1] AOC3 💬

Hydralazine 💬

[1] 67 💬

Butanoate metabolism 💬

[1] ABAT 💬

Vigabatrin 💬

[2] 145, 158 💬

Butanoate metabolism 💬

[4] ABAT, ALDH5A1, GAD1, GAD2 💬

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Caffeine metabolism 💬

[1] XDH 💬

Allopurinol 💬

[7] 6 , 46, 57, 60, 66, 96, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

Caffeine metabolism 💬

[1] XDH 💬

Febuxostat 💬

[3] 2 , 6 , 13 💬

Calcium signaling pathway 💬

[2] KDR, MET 💬

Cabozantinib 💬

[1] 34 💬

Carbon metabolism 💬

[1] CPS1 💬

[3] 245, 246, 251 💬

Carbon metabolism 💬

[1] HAO1 💬

Lumasiran 💬

Lumasiran

[1] 234 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

[2] EGFR, ERBB2 💬

Neratinib 💬

Neratinib

[1] 34 💬

[2] EGFR, ERBB2 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

[3] FGFR1, FGFR2, FGFR3 💬

Infigratinib 💬

Infigratinib

[1] 276 💬

[5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB 💬

Name	Full Name
FGFR1	fibroblast growth factor receptor 1
FGFR2	fibroblast growth factor receptor 2
FGFR3	fibroblast growth factor receptor 3
PDGFRA	platelet derived growth factor receptor alpha
PDGFRB	platelet derived growth factor receptor beta

Nintedanib 💬

Nintedanib

[5] 51, 85, 89, 227, 228 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

[1] FGFR2 💬

Palifermin 💬

Palifermin

[5] 13, 36, 38, 39, 65 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
65	Primary immunodeficiency;

[2] FLT3, KIT 💬

Pexidartinib 💬

Pexidartinib

[1] 34 💬

[5] FLT3, KIT, PDGFRA, PDGFRB, RET 💬

Name	Full Name
FLT3	fms related receptor tyrosine kinase 3
KIT	KIT proto-oncogene, receptor tyrosine kinase
PDGFRA	platelet derived growth factor receptor alpha
PDGFRB	platelet derived growth factor receptor beta
RET	ret proto-oncogene

Sunitinib 💬

Sunitinib

[2] 28, 34 💬

[5] FLT3, KIT, PDGFRB, RAF1, RET 💬

Name	Full Name
FLT3	fms related receptor tyrosine kinase 3
KIT	KIT proto-oncogene, receptor tyrosine kinase
PDGFRB	platelet derived growth factor receptor beta
RAF1	Raf-1 proto-oncogene, serine/threonine kinase
RET	ret proto-oncogene

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

[1] KIT 💬

Masitinib 💬

Masitinib

[6] 2 , 5 , 6 , 13, 46, 96 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
96	Crohn disease;Terminal ileitis;

[2] KIT, PDGFRA 💬

Imatinib 💬

Imatinib

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

[3] KIT, PDGFRA, PDGFRB 💬

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

[2] KIT, PDGFRB 💬

Dasatinib 💬

[2] 51, 85 💬

[2] KIT, PDGFRB 💬

Dasatinib 💬

[2] 51, 85 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

[1] PIK3CA 💬

Alpelisib 💬

[1] 138 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

[2] 53, 65 💬

[1] PIK3CD 💬

Parsaclisib 💬

[3] 35, 53, 61 💬

Chemical carcinogenesis - reactive oxygen species 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

[1] ANGPTL3 💬

Evinacumab 💬

Evinacumab

[1] 79 💬

[1] APOC3 💬

Volanesorsen 💬

Volanesorsen

[1] 265 💬

[1] CETP 💬

Anacetrapib 💬

Anacetrapib

[1] 79 💬

[1] LIPA 💬

Sebelipase alfa 💬

Sebelipase alfa

[1] 19 💬

[1] PCSK9 💬

Alirocumab 💬

Alirocumab

[1] 79 💬

[1] PCSK9 💬

Evolocumab 💬

Evolocumab

[2] 79, 222 💬

[1] PCSK9 💬

Inclisiran 💬

Inclisiran

[1] 79 💬

[1] SORT1 💬

Latozinemab 💬

Latozinemab

[2] 2 , 127 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

[1] EGFR 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

[1] EGFR 💬

Neratinib 💬

Neratinib

[1] 34 💬

[1] EGFR 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

100

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

101

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

102

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

103

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

104

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

105

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

106

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

107

[1] PDGFRA 💬

Imatinib 💬

Imatinib

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

108

[2] PDGFRA, PDGFRB 💬

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

109

[2] PDGFRA, PDGFRB 💬

Nintedanib 💬

Nintedanib

[5] 51, 85, 89, 227, 228 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

110

[2] PDGFRA, PDGFRB 💬

Sunitinib 💬

Sunitinib

[2] 28, 34 💬

111

[1] PDGFRB 💬

Dasatinib 💬

[2] 51, 85 💬

112

[1] PDGFRB 💬

Dasatinib 💬

[2] 51, 85 💬

113

[2] PDGFRB, RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

114

[1] PIK3CA 💬

Alpelisib 💬

[1] 138 💬

115

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

[2] 53, 65 💬

116

[1] PIK3CD 💬

Parsaclisib 💬

[3] 35, 53, 61 💬

117

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

118

Cysteine and methionine metabolism 💬

[3] DNMT1, DNMT3A, DNMT3B 💬

Decitabine 💬

Decitabine

[3] 13, 60, 63 💬

119

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

[1] 301 💬

120

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

121

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

122

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

123

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

124

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

125

[1] MAOB 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

126

[1] MAOB 💬

Safinamide 💬

[2] 6 , 17 💬

127

[1] MAOB 💬

Selegiline 💬

[1] 6 💬

128

[1] GUSB 💬

[1] 19 💬

129

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

130

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

131

[1] HPRT1 💬

Tioguanine 💬

[2] 13, 37 💬

132

[2] IMPDH1, IMPDH2 💬

Mizoribine 💬

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
94	Primary sclerosing cholangitis;PSC;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

133

[2] IMPDH1, IMPDH2 💬

[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

134

[2] IMPDH1, IMPDH2 💬

[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

135

[1] MPO 💬

Verdiperstat 💬

Verdiperstat

[3] 2 , 17, 127 💬

136

[1] RRM1 💬

Cladribine 💬

[3] 11, 13, 94 💬

137

[1] RRM1 💬

Clofarabine 💬

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

138

[1] RRM1 💬

Fludarabine 💬

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

139

[1] RRM2 💬

Hydroxyurea 💬

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

140

[1] XDH 💬

Allopurinol 💬

[7] 6 , 46, 57, 60, 66, 96, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

141

[1] XDH 💬

Febuxostat 💬

[3] 2 , 6 , 13 💬

142

EGFR tyrosine kinase inhibitor resistance 💬

[3] AXL, KDR, MET 💬

Cabozantinib 💬

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] 34 💬

143

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

144

Ether lipid metabolism 💬

[1] ENPP2 💬

Ziritaxestat 💬

Ziritaxestat

[2] 51, 85 💬

145

Fatty acid metabolism 💬

[4] CPT1A, CPT1B, CPT1C, CPT2 💬

Perhexiline 💬

Perhexiline

[2] 58, 272 💬

146

Focal adhesion 💬

[2] KDR, MET 💬

Cabozantinib 💬

[1] 34 💬

147

[1] GAA 💬

Alglucosidase alfa 💬

Alglucosidase alfa

[1] 256 💬

148

[1] GAA 💬

Avalglucosidase alfa 💬

Avalglucosidase alfa

[1] 256 💬

149

[1] GAA 💬

Cipaglucosidase alfa 💬

Cipaglucosidase alfa

[1] 256 💬

150

[1] GAA 💬

Duvoglustat 💬

Duvoglustat

[1] 256 💬

151

[3] GAA, GANC, MGAM 💬

Acarbose 💬

Acarbose

[1] 298 💬

152

[1] GLA 💬

[1] 19 💬

153

[1] GLA 💬

[1] 19 💬

154

Gastric cancer 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

155

[1] ANPEP 💬

Ubenimex 💬

Ubenimex

[1] 86 💬

156

[1] ODC1 💬

Eflornithine 💬

Eflornithine

[1] 65 💬

157

[1] RRM1 💬

Cladribine 💬

[3] 11, 13, 94 💬

158

[1] RRM1 💬

Clofarabine 💬

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

159

[1] RRM1 💬

Fludarabine 💬

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

160

[1] RRM2 💬

Hydroxyurea 💬

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

161

Glycerolipid metabolism 💬

[1] GLA 💬

[1] 19 💬

162

Glycerolipid metabolism 💬

[1] GLA 💬

[1] 19 💬

163

[1] ACHE 💬

Donepezil 💬

Donepezil

[9] 5 , 6 , 13, 46, 78, 124, 127, 156, 206 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;
127	Frontotemporal lobar degeneration;
156	Rett syndrome;
206	Fragile X syndrome;

164

[1] ACHE 💬

Galantamine 💬

Galantamine

[2] 6 , 127 💬

165

[1] ACHE 💬

Latrepirdine 💬

Latrepirdine

[1] 8 💬

166

[1] ACHE 💬

Rivastigmine 💬

Rivastigmine

[3] 5 , 6 , 13 💬

167

[1] ACHE 💬

Tacrine 💬

Tacrine

[2] 46, 271 💬

168

[1] ALAS1 💬

Givosiran 💬

Givosiran

[1] 254 💬

169

[2] ALAS1, ALAS2 💬

Hemin 💬

Hemin

[1] 254 💬

170

[1] AOC3 💬

Hydralazine 💬

[1] 67 💬

171

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

172

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

173

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

174

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

175

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

176

[1] MAOB 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

177

[1] MAOB 💬

Safinamide 💬

[2] 6 , 17 💬

178

[1] MAOB 💬

Selegiline 💬

[1] 6 💬

179

Glyoxylate and dicarboxylate metabolism 💬

[1] HAO1 💬

Lumasiran 💬

Lumasiran

[1] 234 💬

180

Hepatocellular carcinoma 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

181

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

182

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

183

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

184

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

185

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

186

[1] MAOB 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

187

[1] MAOB 💬

Safinamide 💬

[2] 6 , 17 💬

188

[1] MAOB 💬

Selegiline 💬

[1] 6 💬

189

Inositol phosphate metabolism 💬

[1] PIK3CA 💬

Alpelisib 💬

[1] 138 💬

190

Inositol phosphate metabolism 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

[2] 53, 65 💬

191

Inositol phosphate metabolism 💬

[1] PIK3CD 💬

Parsaclisib 💬

[3] 35, 53, 61 💬

192

Malaria 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

193

MAPK signaling pathway 💬

[2] KDR, MET 💬

Cabozantinib 💬

[1] 34 💬

194

Melanoma 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

195

[1] ABAT 💬

Vigabatrin 💬

[2] 145, 158 💬

196

[4] ABAT, ALDH5A1, GAD1, GAD2 💬

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

197

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

[1] 301 💬

198

[1] ALAS1 💬

Givosiran 💬

Givosiran

[1] 254 💬

199

[2] ALAS1, ALAS2 💬

Hemin 💬

Hemin

[1] 254 💬

200

[1] ALOX5 💬

Oxatomide 💬

Oxatomide

[1] 113 💬

201

[1] ALOX5 💬

Zileuton 💬

Zileuton

[3] 85, 160, 164 💬

202

[1] ALPL 💬

Asfotase alfa 💬

Asfotase alfa

[1] 172 💬

203

[5] AMY2A, AMY2B, GAA, GANC, MGAM 💬

Acarbose 💬

Acarbose

[1] 298 💬

204

[1] ANPEP 💬

Ubenimex 💬

Ubenimex

[1] 86 💬

205

[1] AOC3 💬

Hydralazine 💬

[1] 67 💬

206

[1] ARSB 💬

Galsulfase 💬

Galsulfase

[1] 19 💬

207

[2] ATP4A, ATP4B 💬

Dexlansoprazole 💬

Dexlansoprazole

[1] 98 💬

208

[2] ATP4A, ATP4B 💬

Esomeprazole 💬

Esomeprazole

[8] 13, 46, 86, 98, 107, 113, 298, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
86	Pulmonary arterial hypertension;PAH;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

209

[2] ATP4A, ATP4B 💬

Lansoprazole 💬

Lansoprazole

[7] 63, 71, 85, 98, 166, 222, 299 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
71	Idiopathic osteonecrosis of the femoral head;Idiopathic femoral head necrosis;
85	Idiopathic interstitial pneumonia;IIPs;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
166	Pseudoxanthoma elasticum;PXE;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

210

[2] ATP4A, ATP4B 💬

Omeprazole 💬

Omeprazole

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

211

[2] ATP4A, ATP4B 💬

Pantoprazole 💬

Pantoprazole

[2] 13, 65 💬

212

[2] ATP4A, ATP4B 💬

Rabeprazole 💬

Rabeprazole

[2] 2 , 51 💬

213

[2] ATP4A, ATP4B 💬

Vonoprazan 💬

Vonoprazan

[2] 63, 98 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

214

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

215

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Dichlorphenamide 💬

Diclofenamide

[1] 114 💬

216

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Dorzolamide 💬

Dorzolamide

[1] 90 💬

217

[2] CA2, CA4 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

218

[1] CD38 💬

Daratumumab 💬

Daratumumab

[5] 13, 28, 48, 49, 63 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
48	Primary antiphospholipid syndrome;Primary antiphospholipid antibody syndrome;Primary APS;PAPS;
49	Systemic lupus erythematosus;SLE;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;

219

[1] CD38 💬

Isatuximab 💬

Isatuximab

[3] 28, 61, 283 💬

220

[1] CD38 💬

Mezagitamab 💬

Mezagitamab

[2] 63, 66 💬

221

[1] COMT 💬

Entacapone 💬

Entacapone

[2] 6 , 17 💬

222

[1] COMT 💬

Opicapone 💬

Opicapone

[1] 6 💬

223

[1] COMT 💬

Tolcapone 💬

Tolcapone

[3] 6 , 28, 127 💬

224

[1] CPS1 💬

[3] 245, 246, 251 💬

225

[3] CYP11A1, CYP11B1, CYP17A1 💬

Levoketoconazole 💬

Levoketoconazole

[1] 75 💬

226

[1] CYP11B1 💬

Metyrapone 💬

Metyrapone

[1] 75 💬

227

[1] CYP11B2 💬

Osilodrostat 💬

Osilodrostat

[1] 75 💬

228

[1] CYP17A1 💬

Ketoconazole 💬

Ketoconazole

[3] 8 , 13, 75 💬

229

[1] CYP19A1 💬

Anastrozole 💬

Anastrozole

[3] 78, 86, 193 💬

230

[1] CYP19A1 💬

Letrozole 💬

Letrozole

[2] 81, 89 💬

231

[1] DDC 💬

Benserazide 💬

[1] 6 💬

232

[1] DDC 💬

Carbidopa 💬

[7] 6 , 13, 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
90	Retinitis pigmentosa;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;
201	Angelman syndrome;

233

[2] DHFR, DHFR2 💬

Methotrexate 💬

Methotrexate

[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
164	Oculocutaneous albinism;
172	Hypophosphatasia;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

234

[1] DHODH 💬

Leflunomide 💬

Leflunomide

[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
224	Purpura nephritis;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

235

[1] DHODH 💬

Teriflunomide 💬

Teriflunomide

[3] 13, 25, 26 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;

236

[3] DNMT1, DNMT3A, DNMT3B 💬

Decitabine 💬

Decitabine

[3] 13, 60, 63 💬

237

[1] ENPP2 💬

Ziritaxestat 💬

Ziritaxestat

[2] 51, 85 💬

238

[1] FDPS 💬

Alendronic acid 💬

Alendronic acid

[7] 19, 41, 46, 50, 271, 274, 299 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
274	Osteogenesis Imperfecta;
299	Cystic fibrosis;

239

[1] FDPS 💬

Pamidronic acid 💬

Pamidronic acid

[3] 270, 271, 274 💬

240

[1] FDPS 💬

Risedronic acid 💬

Risedronic acid

[9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
274	Osteogenesis Imperfecta;

241

[1] FDPS 💬

Zoledronic acid 💬

Zoledronic acid

[13] 5 , 6 , 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
270	Chronic recurrent multifocal osteomyelitis;
274	Osteogenesis Imperfecta;
299	Cystic fibrosis;
333	Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;

242

[1] FDPS 💬

Zoledronic acid 💬

Zoledronic acid

[13] 5 , 6 , 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
270	Chronic recurrent multifocal osteomyelitis;
274	Osteogenesis Imperfecta;
299	Cystic fibrosis;
333	Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;

243

[1] GAA 💬

Alglucosidase alfa 💬

Alglucosidase alfa

[1] 256 💬

244

[1] GAA 💬

Avalglucosidase alfa 💬

Avalglucosidase alfa

[1] 256 💬

245

[1] GAA 💬

Cipaglucosidase alfa 💬

Cipaglucosidase alfa

[1] 256 💬

246

[1] GAA 💬

Duvoglustat 💬

Duvoglustat

[1] 256 💬

247

[1] GALNS 💬

Elosulfase alfa 💬

Elosulfase alfa

[1] 19 💬

248

[1] GBA1 💬

Alglucerase 💬

Alglucerase

[1] 19 💬

249

[1] GBA1 💬

Imiglucerase 💬

Imiglucerase

[1] 19 💬

250

[1] GBA1 💬

Taliglucerase alfa 💬

Taliglucerase alfa

[1] 19 💬

251

[1] GBA1 💬

Velaglucerase alfa 💬

Velaglucerase alfa

[1] 19 💬

252

[1] GLA 💬

[1] 19 💬

253

[1] GLA 💬

[1] 19 💬

254

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

Amyl Nitrite

[1] 58 💬

255

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Riociguat 💬

Riociguat

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

256

[1] GUCY2C 💬

Linaclotide 💬

Linaclotide

[2] 6 , 97 💬

257

[1] GUSB 💬

[1] 19 💬

258

[1] HAO1 💬

Lumasiran 💬

Lumasiran

[1] 234 💬

259

[1] HMGCR 💬

Atorvastatin 💬

Atorvastatin

[19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
79	Homozygous familial hypercholesterolemia;
84	Sarcoidosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
160	Congenital ichthyosis;
222	Primary nephrotic syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
265	Lipodystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
297	Alagille syndrome;
299	Cystic fibrosis;

260

[1] HMGCR 💬

Fluvastatin 💬

Fluvastatin

[3] 79, 218, 222 💬

261

[1] HMGCR 💬

Lovastatin 💬

Lovastatin

[11] 6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
79	Homozygous familial hypercholesterolemia;
156	Rett syndrome;
160	Congenital ichthyosis;
195	Noonan syndrome;
206	Fragile X syndrome;
263	Cerebrotendinous xanthomatosis;27-hydroxylase deficiency;CYP27 deficiency;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
310	Congenital anomalies syndrome;

262

[1] HMGCR 💬

Pravastatin 💬

Pravastatin

[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
79	Homozygous familial hypercholesterolemia;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
265	Lipodystrophy;
333	Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;

263

[1] HMGCR 💬

Rosuvastatin 💬

Rosuvastatin

[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
18	Spinocerebellar degeneration;SCD;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
56	Behcet disease;Behçet disease;BD;
79	Homozygous familial hypercholesterolemia;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

264

[1] HMGCR 💬

Simvastatin 💬

Simvastatin

[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
79	Homozygous familial hypercholesterolemia;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
94	Primary sclerosing cholangitis;PSC;
158	Tuberous sclerosis;Tuberous sclerosis complex;
160	Congenital ichthyosis;
162	Pemphigoid;
195	Noonan syndrome;
265	Lipodystrophy;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;
310	Congenital anomalies syndrome;

265

[2] HMOX1, HMOX2 💬

Stannsoporfin 💬

Stannsoporfin

[1] 254 💬

266

[1] HPD 💬

Nitisinone 💬

Nitisinone

[3] 6 , 164, 241 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
164	Oculocutaneous albinism;
241	Hypertyrosinemia type I;Tyrosinemia type I;Tyrosinemia I;Hereditary tyrosinemia, Type I;Fumarylacetoacetate hydrolase deficiency;FAH deficiency;

267

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

268

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

269

[1] HPRT1 💬

Tioguanine 💬

[2] 13, 37 💬

270

[1] IDS 💬

Idursulfase 💬

Idursulfase

[1] 19 💬

271

[1] IDS 💬

Idursulfase beta 💬

Idursulfase beta

[1] 19 💬

272

[1] IDS 💬

Pabinafusp alfa 💬

Pabinafusp alfa

[1] 19 💬

273

[1] IDUA 💬

Laronidase 💬

Laronidase

[2] 19, 256 💬

274

[2] IMPDH1, IMPDH2 💬

Mizoribine 💬

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
94	Primary sclerosing cholangitis;PSC;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

275

[2] IMPDH1, IMPDH2 💬

[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

276

[2] IMPDH1, IMPDH2 💬

[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

277

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

278

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

279

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

280

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

281

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

282

[1] MAOB 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

283

[1] MAOB 💬

Safinamide 💬

[2] 6 , 17 💬

284

[1] MAOB 💬

Selegiline 💬

[1] 6 💬

285

[1] NPR1 💬

Nesiritide 💬

Nesiritide

[2] 46, 58 💬

286

[2] NPR1, NPR2 💬

Erythrityl tetranitrate 💬

Erythrityl tetranitrate

[1] 46 💬

287

[1] NPR2 💬

Vosoritide 💬

Vosoritide

[1] 276 💬

288

[2] NQO1, VKORC1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

289

[1] ODC1 💬

Eflornithine 💬

Eflornithine

[1] 65 💬

290

[1] PAH 💬

Pegvaliase 💬

Pegvaliase

[1] 240 💬

291

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Aminophylline 💬

Aminophylline

[1] 63 💬

292

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Bucladesine 💬

Bucladesine

[1] 246 💬

293

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Flavoxate 💬

Flavoxate

[1] 226 💬

294

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

[2] 236, 299 💬

295

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

[2] 236, 299 💬

296

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

297

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine hydrate 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

298

[2] PDE3A, PDE3B 💬

Cilostazol 💬

Cilostazol

[3] 46, 51, 70 💬

299

[2] PDE3A, PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

300

[2] PDE3A, PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

301

[6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

302

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Apremilast 💬

Apremilast

[7] 46, 50, 56, 97, 107, 162, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
56	Behcet disease;Behçet disease;BD;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

303

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Roflumilast 💬

Roflumilast

[4] 84, 97, 206, 299 💬

304

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Rolipram 💬

Rolipram

[2] 8 , 13 💬

305

[2] PDE4A, PDE5A 💬

Dipyridamole 💬

Dipyridamole

[6] 46, 49, 51, 66, 96, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
224	Purpura nephritis;

306

[1] PDE4D 💬

Zatolmilast 💬

Zatolmilast

[1] 206 💬

307

[1] PDE5A 💬

Sildenafil 💬

Sildenafil

[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
294	Congenital diaphragmatic hernia;
299	Cystic fibrosis;
301	Macular dystrophy;

308

[1] PDE5A 💬

Tadalafil 💬

Tadalafil

[7] 6 , 51, 75, 84, 86, 113, 210 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

309

[1] PDE5A 💬

Udenafil 💬

Udenafil

[2] 86, 210 💬

310

[1] PDE5A 💬

Vardenafil 💬

Vardenafil

[3] 13, 86, 299 💬

311

[1] PIK3CA 💬

Alpelisib 💬

[1] 138 💬

312

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

[2] 53, 65 💬

313

[1] PIK3CD 💬

Parsaclisib 💬

[3] 35, 53, 61 💬

314

[3] PTGES, PTGS1, PTGS2 💬

Aceclofenac 💬

Aceclofenac

[1] 46 💬

315

[2] PTGS1, PTGS2 💬

Acetaminophen 💬

Acetaminophen

[15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
337	Homocystinuria;

316

[2] PTGS1, PTGS2 💬

Aspirin 💬

Acetylsalicylic acid

[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
64	Thrombotic thrombocytopenic purpura;TTP;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
158	Tuberous sclerosis;Tuberous sclerosis complex;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
231	Alpha-1-antitrypsin deficiency;AATD;
251	Urea cycle disorder;

317

[2] PTGS1, PTGS2 💬

Diclofenac 💬

Diclofenac

[5] 13, 34, 46, 78, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

318

[2] PTGS1, PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

319

[2] PTGS1, PTGS2 💬

Ibuprofen 💬

Ibuprofen

[7] 13, 46, 65, 107, 113, 271, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

320

[2] PTGS1, PTGS2 💬

Indomethacin 💬

Indomethacin

[3] 225, 271, 298 💬

Disease ID	Name
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
298	Hereditary pancreatitis;Chronic pancreatitis;

321

[2] PTGS1, PTGS2 💬

Ketoprofen 💬

Ketoprofen

[1] 46 💬

322

[2] PTGS1, PTGS2 💬

Ketorolac 💬

Ketorolac

[2] 70, 226 💬

323

[2] PTGS1, PTGS2 💬

Loxoprofen 💬

Loxoprofen

[2] 46, 271 💬

324

[2] PTGS1, PTGS2 💬

Naproxen 💬

Naproxen

[4] 13, 46, 107, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

325

[2] PTGS1, PTGS2 💬

Salsalate 💬

Salsalate

[1] 5 💬

326

[2] PTGS1, PTGS2 💬

Sulindac 💬

Sulindac

[1] 206 💬

327

[2] PTGS1, PTGS2 💬

Tolfenamic acid 💬

Tolfenamic acid

[1] 5 💬

328

[1] PTGS2 💬

Celecoxib 💬

Celecoxib

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

329

[1] PTGS2 💬

Diflunisal 💬

Diflunisal

[1] 28 💬

330

[1] PTGS2 💬

Etodolac 💬

Etodolac

[1] 46 💬

331

[1] PTGS2 💬

Etoricoxib 💬

Etoricoxib

[2] 46, 271 💬

332

[1] PTGS2 💬

Lumiracoxib 💬

Lumiracoxib

[1] 46 💬

333

[1] PTGS2 💬

Meloxicam 💬

Meloxicam

[4] 46, 49, 271, 296 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
296	Biliary atresia;

334

[1] PTGS2 💬

Nimesulide 💬

Nimesulide

[1] 46 💬

335

[1] PTGS2 💬

Parecoxib 💬

Parecoxib

[2] 46, 271 💬

336

[1] PTGS2 💬

Rofecoxib 💬

Rofecoxib

[1] 46 💬

337

[1] PTGS2 💬

Valdecoxib 💬

Valdecoxib

[1] 46 💬

338

[1] RRM1 💬

Cladribine 💬

[3] 11, 13, 94 💬

339

[1] RRM1 💬

Clofarabine 💬

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

340

[1] RRM1 💬

Fludarabine 💬

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

341

[1] RRM2 💬

Hydroxyurea 💬

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

342

[1] SMPD1 💬

Olipudase alfa 💬

Olipudase alfa

[1] 19 💬

343

[2] SRD5A1, SRD5A2 💬

Dutasteride 💬

Dutasteride

[2] 1 , 2 💬

344

[1] SRD5A2 💬

Finasteride 💬

Finasteride

[1] 6 💬

345

[2] TPH1, TPH2 💬

Telotristat 💬

Telotristat

[1] 97 💬

346

[1] TPO 💬

Methimazole 💬

Methimazole

[1] 50 💬

347

[1] TYMS 💬

Tegafur 💬

Tegafur

[1] 46 💬

348

[1] UGCG 💬

Eliglustat 💬

Eliglustat

[1] 19 💬

349

[1] UGCG 💬

Lucerastat 💬

Lucerastat

[1] 19 💬

350

[1] UGCG 💬

Miglustat 💬

Miglustat

[3] 19, 256, 299 💬

351

[1] UGCG 💬

Venglustat 💬

Venglustat

[3] 6 , 19, 67 💬

352

[1] VKORC1 💬

Phenindione 💬

Phenindione

[1] 65 💬

353

[1] XDH 💬

Allopurinol 💬

[7] 6 , 46, 57, 60, 66, 96, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

354

[1] XDH 💬

Febuxostat 💬

[3] 2 , 6 , 13 💬

355

Metabolism of xenobiotics by cytochrome P450 💬

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

[1] 301 💬

356

MicroRNAs in cancer 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

357

Nicotinate and nicotinamide metabolism 💬

[1] CD38 💬

Daratumumab 💬

Daratumumab

[5] 13, 28, 48, 49, 63 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
48	Primary antiphospholipid syndrome;Primary antiphospholipid antibody syndrome;Primary APS;PAPS;
49	Systemic lupus erythematosus;SLE;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;

358

Nicotinate and nicotinamide metabolism 💬

[1] CD38 💬

Isatuximab 💬

Isatuximab

[3] 28, 61, 283 💬

359

Nicotinate and nicotinamide metabolism 💬

[1] CD38 💬

Mezagitamab 💬

Mezagitamab

[2] 63, 66 💬

360

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

361

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Dichlorphenamide 💬

Diclofenamide

[1] 114 💬

362

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Dorzolamide 💬

Dorzolamide

[1] 90 💬

363

[2] CA2, CA4 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

364

[1] CPS1 💬

[3] 245, 246, 251 💬

365

Non-small cell lung cancer 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

366

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

367

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

368

[1] HPRT1 💬

Tioguanine 💬

[2] 13, 37 💬

369

[2] IMPDH1, IMPDH2 💬

Mizoribine 💬

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
94	Primary sclerosing cholangitis;PSC;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

370

[2] IMPDH1, IMPDH2 💬

[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

371

[2] IMPDH1, IMPDH2 💬

[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

372

[1] RRM1 💬

Cladribine 💬

[3] 11, 13, 94 💬

373

[1] RRM1 💬

Clofarabine 💬

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

374

[1] RRM1 💬

Fludarabine 💬

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

375

[1] RRM2 💬

Hydroxyurea 💬

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

376

[1] TYMS 💬

Tegafur 💬

Tegafur

[1] 46 💬

377

[1] XDH 💬

Allopurinol 💬

[7] 6 , 46, 57, 60, 66, 96, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

378

[1] XDH 💬

Febuxostat 💬

[3] 2 , 6 , 13 💬

379

Pathways in cancer 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

380

[1] AOC3 💬

Hydralazine 💬

[1] 67 💬

381

[1] DDC 💬

Benserazide 💬

[1] 6 💬

382

[1] DDC 💬

Carbidopa 💬

[7] 6 , 13, 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
90	Retinitis pigmentosa;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;
201	Angelman syndrome;

383

[1] HPD 💬

Nitisinone 💬

Nitisinone

[3] 6 , 164, 241 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
164	Oculocutaneous albinism;
241	Hypertyrosinemia type I;Tyrosinemia type I;Tyrosinemia I;Hereditary tyrosinemia, Type I;Fumarylacetoacetate hydrolase deficiency;FAH deficiency;

384

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

385

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

386

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

387

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

388

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

389

[1] MAOB 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

390

[1] MAOB 💬

Safinamide 💬

[2] 6 , 17 💬

391

[1] MAOB 💬

Selegiline 💬

[1] 6 💬

392

[1] PAH 💬

Pegvaliase 💬

Pegvaliase

[1] 240 💬

393

PI3K-Akt signaling pathway 💬

[2] KDR, MET 💬

Cabozantinib 💬

[1] 34 💬

394

[1] ALAS1 💬

Givosiran 💬

Givosiran

[1] 254 💬

395

[2] ALAS1, ALAS2 💬

Hemin 💬

Hemin

[1] 254 💬

396

[1] GUSB 💬

[1] 19 💬

397

[2] HMOX1, HMOX2 💬

Stannsoporfin 💬

Stannsoporfin

[1] 254 💬

398

Propanoate metabolism 💬

[1] ABAT 💬

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

399

Propanoate metabolism 💬

[1] ABAT 💬

Vigabatrin 💬

[2] 145, 158 💬

400

Proteoglycans in cancer 💬

[2] KDR, MET 💬

Cabozantinib 💬

[1] 34 💬

401

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

Amyl Nitrite

[1] 58 💬

402

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Riociguat 💬

Riociguat

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

403

[1] GUCY2C 💬

Linaclotide 💬

Linaclotide

[2] 6 , 97 💬

404

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

405

[1] HPRT1 💬

[4] 65, 96, 97, 164 💬

406

[1] HPRT1 💬

Tioguanine 💬

[2] 13, 37 💬

407

[2] IMPDH1, IMPDH2 💬

Mizoribine 💬

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
94	Primary sclerosing cholangitis;PSC;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

408

[2] IMPDH1, IMPDH2 💬

[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

409

[2] IMPDH1, IMPDH2 💬

[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

410

[1] NPR1 💬

Nesiritide 💬

Nesiritide

[2] 46, 58 💬

411

[2] NPR1, NPR2 💬

Erythrityl tetranitrate 💬

Erythrityl tetranitrate

[1] 46 💬

412

[1] NPR2 💬

Vosoritide 💬

Vosoritide

[1] 276 💬

413

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Aminophylline 💬

Aminophylline

[1] 63 💬

414

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Bucladesine 💬

Bucladesine

[1] 246 💬

415

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Flavoxate 💬

Flavoxate

[1] 226 💬

416

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

[2] 236, 299 💬

417

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

[2] 236, 299 💬

418

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

419

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine hydrate 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

420

[2] PDE3A, PDE3B 💬

Cilostazol 💬

Cilostazol

[3] 46, 51, 70 💬

421

[2] PDE3A, PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

422

[2] PDE3A, PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

423

[6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

424

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Apremilast 💬

Apremilast

[7] 46, 50, 56, 97, 107, 162, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
56	Behcet disease;Behçet disease;BD;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

425

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Roflumilast 💬

Roflumilast

[4] 84, 97, 206, 299 💬

426

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Rolipram 💬

Rolipram

[2] 8 , 13 💬

427

[2] PDE4A, PDE5A 💬

Dipyridamole 💬

Dipyridamole

[6] 46, 49, 51, 66, 96, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
224	Purpura nephritis;

428

[1] PDE4D 💬

Zatolmilast 💬

Zatolmilast

[1] 206 💬

429

[1] PDE5A 💬

Sildenafil 💬

Sildenafil

[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
294	Congenital diaphragmatic hernia;
299	Cystic fibrosis;
301	Macular dystrophy;

430

[1] PDE5A 💬

Tadalafil 💬

Tadalafil

[7] 6 , 51, 75, 84, 86, 113, 210 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

431

[1] PDE5A 💬

Udenafil 💬

Udenafil

[2] 86, 210 💬

432

[1] PDE5A 💬

Vardenafil 💬

Vardenafil

[3] 13, 86, 299 💬

433

[1] RRM1 💬

Cladribine 💬

[3] 11, 13, 94 💬

434

[1] RRM1 💬

Clofarabine 💬

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

435

[1] RRM1 💬

Fludarabine 💬

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

436

[1] RRM2 💬

Hydroxyurea 💬

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

437

[1] XDH 💬

Allopurinol 💬

[7] 6 , 46, 57, 60, 66, 96, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

438

[1] XDH 💬

Febuxostat 💬

[3] 2 , 6 , 13 💬

439

[1] DHODH 💬

Leflunomide 💬

Leflunomide

[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
224	Purpura nephritis;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

440

[1] DHODH 💬

Teriflunomide 💬

Teriflunomide

[3] 13, 25, 26 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;

441

[1] RRM1 💬

Cladribine 💬

[3] 11, 13, 94 💬

442

[1] RRM1 💬

Clofarabine 💬

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

443

[1] RRM1 💬

Fludarabine 💬

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

444

[1] RRM2 💬

Hydroxyurea 💬

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

445

[1] TYMS 💬

Tegafur 💬

Tegafur

[1] 46 💬

446

Pyruvate metabolism 💬

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

[1] 301 💬

447

Rap1 signaling pathway 💬

[2] KDR, MET 💬

Cabozantinib 💬

[1] 34 💬

448

Ras signaling pathway 💬

[2] KDR, MET 💬

Cabozantinib 💬

[1] 34 💬

449

Renal cell carcinoma 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

450

Retinol metabolism 💬

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

[1] 301 💬

451

[1] GBA1 💬

Alglucerase 💬

Alglucerase

[1] 19 💬

452

[1] GBA1 💬

Imiglucerase 💬

Imiglucerase

[1] 19 💬

453

[1] GBA1 💬

Taliglucerase alfa 💬

Taliglucerase alfa

[1] 19 💬

454

[1] GBA1 💬

Velaglucerase alfa 💬

Velaglucerase alfa

[1] 19 💬

455

[1] GLA 💬

[1] 19 💬

456

[1] GLA 💬

[1] 19 💬

457

[1] SMPD1 💬

Olipudase alfa 💬

Olipudase alfa

[1] 19 💬

458

[1] UGCG 💬

Eliglustat 💬

Eliglustat

[1] 19 💬

459

[1] UGCG 💬

Lucerastat 💬

Lucerastat

[1] 19 💬

460

[1] UGCG 💬

Miglustat 💬

Miglustat

[3] 19, 256, 299 💬

461

[1] UGCG 💬

Venglustat 💬

Venglustat

[3] 6 , 19, 67 💬

462

[5] AMY2A, AMY2B, GAA, GANC, MGAM 💬

Acarbose 💬

Acarbose

[1] 298 💬

463

[1] GAA 💬

Alglucosidase alfa 💬

Alglucosidase alfa

[1] 256 💬

464

[1] GAA 💬

Avalglucosidase alfa 💬

Avalglucosidase alfa

[1] 256 💬

465

[1] GAA 💬

Cipaglucosidase alfa 💬

Cipaglucosidase alfa

[1] 256 💬

466

[1] GAA 💬

Duvoglustat 💬

Duvoglustat

[1] 256 💬

467

Taurine and hypotaurine metabolism 💬

[2] GAD1, GAD2 💬

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

468

Thiamine metabolism 💬

[1] ALPL 💬

Asfotase alfa 💬

Asfotase alfa

[1] 172 💬

469

Transcriptional misregulation in cancer 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

470

[1] DDC 💬

Benserazide 💬

[1] 6 💬

471

[1] DDC 💬

Carbidopa 💬

[7] 6 , 13, 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
90	Retinitis pigmentosa;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;
201	Angelman syndrome;

472

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

473

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

474

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

475

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

476

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

477

[1] MAOB 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

478

[1] MAOB 💬

Safinamide 💬

[2] 6 , 17 💬

479

[1] MAOB 💬

Selegiline 💬

[1] 6 💬

480

[2] TPH1, TPH2 💬

Telotristat 💬

Telotristat

[1] 97 💬

481

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

[1] 301 💬

482

[1] AOC3 💬

Hydralazine 💬

[1] 67 💬

483

[1] COMT 💬

Entacapone 💬

Entacapone

[2] 6 , 17 💬

484

[1] COMT 💬

Opicapone 💬

Opicapone

[1] 6 💬

485

[1] COMT 💬

Tolcapone 💬

Tolcapone

[3] 6 , 28, 127 💬

486

[1] DDC 💬

Benserazide 💬

[1] 6 💬

487

[1] DDC 💬

Carbidopa 💬

[7] 6 , 13, 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
90	Retinitis pigmentosa;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;
201	Angelman syndrome;

488

[1] HPD 💬

Nitisinone 💬

Nitisinone

[3] 6 , 164, 241 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
164	Oculocutaneous albinism;
241	Hypertyrosinemia type I;Tyrosinemia type I;Tyrosinemia I;Hereditary tyrosinemia, Type I;Fumarylacetoacetate hydrolase deficiency;FAH deficiency;

489

[1] MAOA 💬

Moclobemide 💬

[1] 6 💬

490

[2] MAOA, MAOB 💬

Iproniazid 💬

[1] 6 💬

491

[2] MAOA, MAOB 💬

Phenelzine 💬

[1] 6 💬

492

[2] MAOA, MAOB 💬

Phentermine 💬

[1] 97 💬

493

[1] MAOB 💬

Rasagiline 💬

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

494

[1] MAOB 💬