Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Purine metabolism 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

Amyl Nitrite

[1] 58 💬

Purine metabolism 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Riociguat 💬

Riociguat

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

Purine metabolism 💬

[1] GUCY2C 💬

Linaclotide 💬

Linaclotide

[2] 6 , 97 💬

Purine metabolism 💬

[1] HPRT1 💬

Mercaptopurine 💬

Mercaptopurine

[4] 65, 96, 97, 164 💬

Purine metabolism 💬

[1] HPRT1 💬

Mercaptopurine 💬

Mercaptopurine

[4] 65, 96, 97, 164 💬

Purine metabolism 💬

[1] HPRT1 💬

Tioguanine 💬

Tioguanine

[2] 13, 37 💬

Purine metabolism 💬

[2] IMPDH1, IMPDH2 💬

Mizoribine 💬

Mizoribine

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
94	Primary sclerosing cholangitis;PSC;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Purine metabolism 💬

[2] IMPDH1, IMPDH2 💬

Mycophenolate mofetil 💬

Mycophenolate mofetil

[34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

Purine metabolism 💬

[2] IMPDH1, IMPDH2 💬

Mycophenolic acid 💬

Mycophenolic acid

[36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
36	Epidermolysis bullosa;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

Purine metabolism 💬

[1] NPR1 💬

Nesiritide 💬

Nesiritide

[2] 46, 58 💬

Purine metabolism 💬

[2] NPR1, NPR2 💬

Erythrityl tetranitrate 💬

Erythrityl tetranitrate

[1] 46 💬

Purine metabolism 💬

[1] NPR2 💬

Vosoritide 💬

Vosoritide

[1] 276 💬

Purine metabolism 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Aminophylline 💬

Aminophylline

[1] 63 💬

Purine metabolism 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Bucladesine 💬

Bucladesine

[1] 246 💬

Purine metabolism 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Flavoxate 💬

Flavoxate

[1] 226 💬

Purine metabolism 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

Theophylline

[2] 236, 299 💬

Purine metabolism 💬

[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬

Name	Full Name
PDE10A	phosphodiesterase 10A
PDE11A	phosphodiesterase 11A
PDE1A	phosphodiesterase 1A
PDE1B	phosphodiesterase 1B
PDE1C	phosphodiesterase 1C
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE7A	phosphodiesterase 7A
PDE7B	phosphodiesterase 7B
PDE8A	phosphodiesterase 8A
PDE8B	phosphodiesterase 8B

Theophylline 💬

Theophylline

[2] 236, 299 💬

Purine metabolism 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Purine metabolism 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Purine metabolism 💬

[2] PDE3A, PDE3B 💬

Cilostazol 💬

Cilostazol

[3] 46, 51, 70 💬

Purine metabolism 💬

[2] PDE3A, PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

Purine metabolism 💬

[2] PDE3A, PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

Purine metabolism 💬

[6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

Purine metabolism 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Apremilast 💬

Apremilast

[7] 46, 50, 56, 97, 107, 162, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
56	Behcet disease;Behçet disease;BD;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Purine metabolism 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Roflumilast 💬

Roflumilast

[4] 84, 97, 206, 299 💬

Purine metabolism 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Rolipram 💬

Rolipram

[2] 8 , 13 💬

Purine metabolism 💬

[2] PDE4A, PDE5A 💬

Dipyridamole 💬

Dipyridamole

[6] 46, 49, 51, 66, 96, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
224	Purpura nephritis;

Purine metabolism 💬

[1] PDE4D 💬

Zatolmilast 💬

Zatolmilast

[1] 206 💬

Purine metabolism 💬

[1] PDE5A 💬

Sildenafil 💬

Sildenafil

[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
294	Congenital diaphragmatic hernia;
299	Cystic fibrosis;
301	Macular dystrophy;

Purine metabolism 💬

[1] PDE5A 💬

Tadalafil 💬

Tadalafil

[7] 6 , 51, 75, 84, 86, 113, 210 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Purine metabolism 💬

[1] PDE5A 💬

Udenafil 💬

Udenafil

[2] 86, 210 💬

Purine metabolism 💬

[1] PDE5A 💬

Vardenafil 💬

Vardenafil

[3] 13, 86, 299 💬

Purine metabolism 💬

[1] RRM1 💬

Cladribine 💬

Cladribine

[3] 11, 13, 94 💬

Purine metabolism 💬

[1] RRM1 💬

Clofarabine 💬

Clofarabine

[5] 19, 20, 60, 234, 326 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
60	Aplastic anemia;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
326	Osteopetrosis;

Purine metabolism 💬

[1] RRM1 💬

Fludarabine 💬

Fludarabine

[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
326	Osteopetrosis;

Purine metabolism 💬

[1] RRM2 💬

Hydroxyurea 💬

Hydroxyurea

[8] 3 , 13, 19, 20, 65, 85, 86, 284 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
284	Diamond-Blackfan anemia;

Purine metabolism 💬

[1] XDH 💬

Allopurinol 💬

Allopurinol

[7] 6 , 46, 57, 60, 66, 96, 97 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
57	Idiopathic dilated cardiomyopathy;
60	Aplastic anemia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

Purine metabolism 💬

[1] XDH 💬

Febuxostat 💬

Febuxostat

[3] 2 , 6 , 13 💬