Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Ras signaling pathway 💬
 [1] ABL1 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
2 Ras signaling pathway 💬
 [1] ABL1 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
3 Ras signaling pathway 💬
 [4] ABL1, EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
4 Ras signaling pathway 💬
 [4] ABL1, EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
5 Ras signaling pathway 💬
 [3] ABL1, KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
6 Ras signaling pathway 💬
 [4] ABL1, KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
7 Ras signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
8 Ras signaling pathway 💬
 [3] CSF1R, FLT3, KIT 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
9 Ras signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
10 Ras signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
11 Ras signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
12 Ras signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
13 Ras signaling pathway 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
14 Ras signaling pathway 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
15 Ras signaling pathway 💬
 [3] EGFR, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
16 Ras signaling pathway 💬
 [1] FGF23 💬 Burosumab 💬 Burosumab [1] 238 💬
17 Ras signaling pathway 💬
 [3] FGFR1, FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib [1] 276 💬
18 Ras signaling pathway 💬
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
19 Ras signaling pathway 💬
 [1] FGFR2 💬 Palifermin 💬 Palifermin [5] 13, 36, 38, 39, 65 💬
20 Ras signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
21 Ras signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
22 Ras signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
23 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Acamprosate 💬 Acamprosate [2]  6 , 206 💬
24 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Amantadine 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
25 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
26 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine [3]  2 ,  4 , 70 💬
27 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Ketamine 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
28 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Latrepirdine 💬 Latrepirdine [1]  8  💬
29 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Memantine 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
30 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
31 Ras signaling pathway 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
32 Ras signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
33 Ras signaling pathway 💬
 [1] IGF1R 💬 Teprotumumab 💬 Teprotumumab [1] 51 💬
34 Ras signaling pathway 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
35 Ras signaling pathway 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
36 Ras signaling pathway 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [2] 96, 156 💬
37 Ras signaling pathway 💬
 [2] KDR, MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
38 Ras signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
39 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
40 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
41 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
42 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
43 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
44 Ras signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
45 Ras signaling pathway 💬
 [1] NGF 💬 Tanezumab 💬 Tanezumab [2] 226, 298 💬
46 Ras signaling pathway 💬
 [1] NGFR 💬 Cenegermin 💬 Cenegermin [2] 53, 90 💬
47 Ras signaling pathway 💬
 [3] PGF, VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
48 Ras signaling pathway 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
49 Ras signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
50 Ras signaling pathway 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
51 Ras signaling pathway 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
52 Ras signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
53 Ras signaling pathway 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
54 Ras signaling pathway 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬