Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 HIF-1 signaling pathway 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
2 HIF-1 signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
3 HIF-1 signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
4 HIF-1 signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
5 HIF-1 signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
6 HIF-1 signaling pathway 💬
 [2] EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
7 HIF-1 signaling pathway 💬
 [2] EGFR, ERBB2 💬 Neratinib 💬 Neratinib [1] 34 💬
8 HIF-1 signaling pathway 💬
 [2] EGFR, ERBB2 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
9 HIF-1 signaling pathway 💬
 [1] FLT1 💬 Axitinib 💬 Axitinib [1] 34 💬
10 HIF-1 signaling pathway 💬
 [1] FLT1 💬 Cediranib 💬 Cediranib [1] 34 💬
11 HIF-1 signaling pathway 💬
 [1] FLT1 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
12 HIF-1 signaling pathway 💬
 [1] FLT1 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
13 HIF-1 signaling pathway 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
14 HIF-1 signaling pathway 💬
 [1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬
15 HIF-1 signaling pathway 💬
 [1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬
16 HIF-1 signaling pathway 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
17 HIF-1 signaling pathway 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
18 HIF-1 signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
19 HIF-1 signaling pathway 💬
 [1] IGF1R 💬 Teprotumumab 💬 Teprotumumab [1] 51 💬
20 HIF-1 signaling pathway 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
21 HIF-1 signaling pathway 💬
 [1] IL6 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
22 HIF-1 signaling pathway 💬
 [1] IL6 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
23 HIF-1 signaling pathway 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
24 HIF-1 signaling pathway 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
25 HIF-1 signaling pathway 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
26 HIF-1 signaling pathway 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [3] 11, 13, 86 💬
27 HIF-1 signaling pathway 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
28 HIF-1 signaling pathway 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
29 HIF-1 signaling pathway 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
30 HIF-1 signaling pathway 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [2] 96, 156 💬
31 HIF-1 signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
32 HIF-1 signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
33 HIF-1 signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
34 HIF-1 signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
35 HIF-1 signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
36 HIF-1 signaling pathway 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
37 HIF-1 signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
38 HIF-1 signaling pathway 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
39 HIF-1 signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
40 HIF-1 signaling pathway 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
41 HIF-1 signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
42 HIF-1 signaling pathway 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
43 HIF-1 signaling pathway 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
44 HIF-1 signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
45 HIF-1 signaling pathway 💬
 [1] TFRC 💬 Pabinafusp alfa 💬 Pabinafusp alfa [1] 19 💬
46 HIF-1 signaling pathway 💬
 [1] VEGFA 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
47 HIF-1 signaling pathway 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
48 HIF-1 signaling pathway 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬