Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
2 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
3 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
4 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
5 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
6 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
7 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
8 Vascular smooth muscle contraction 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
9 Vascular smooth muscle contraction 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
10 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
11 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
12 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
13 Vascular smooth muscle contraction 💬
 [1] ADRA1A 💬 Alfuzosin 💬 Alfuzosin [1] 13 💬
14 Vascular smooth muscle contraction 💬
 [1] ADRA1A 💬 Silodosin 💬 Silodosin [2]  6 , 13 💬
15 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
16 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Carvedilol 💬 Carvedilol [4] 57, 86, 113, 210 💬
17 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Dipivefrin 💬 Dipivefrin [1]  6  💬
18 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Doxazosin 💬 Doxazosin [2] 57, 67 💬
19 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Droxidopa 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
20 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Ephedrine 💬 Ephedrine [1] 11 💬
21 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Epinephrine 💬 Epinephrine [3] 46, 70, 96 💬
22 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Methylergometrine 💬 Methylergometrine [1] 280 💬
23 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Midodrine 💬 Midodrine [3]  6 , 17, 58 💬
24 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Noradrenaline 💬 Norepinephrine [2] 22, 296 💬
25 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
26 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Phenylephrine 💬 Phenylephrine [1] 22 💬
27 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Pseudoephedrine 💬 Pseudoephedrine [1] 17 💬
28 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Tamsulosin 💬 Tamsulosin [1] 13 💬
29 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 Terazosin 💬 Terazosin [1]  6  💬
30 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
31 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
32 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬
33 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil [1] 67 💬
34 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
35 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
36 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬
37 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
38 Vascular smooth muscle contraction 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
39 Vascular smooth muscle contraction 💬
 [1] AVPR1A 💬 Conivaptan 💬 Conivaptan [1] 86 💬
40 Vascular smooth muscle contraction 💬
 [2] AVPR1A, AVPR1B 💬 Terlipressin 💬 Terlipressin [1] 299 💬
41 Vascular smooth muscle contraction 💬
 [2] AVPR1A, AVPR1B 💬 Vasopressin 💬 Vasopressin [1] 210 💬
42 Vascular smooth muscle contraction 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
43 Vascular smooth muscle contraction 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
44 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
45 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
46 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
47 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
48 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
49 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
50 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
51 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
52 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
53 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
54 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
55 Vascular smooth muscle contraction 💬
 [1] CALCA 💬 Fremanezumab 💬 Fremanezumab [2] 124, 226 💬
56 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
57 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
58 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
59 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
60 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬
61 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬
62 Vascular smooth muscle contraction 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Amyl nitrite 💬 Amyl Nitrite [1] 58 💬
63 Vascular smooth muscle contraction 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
64 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
65 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
66 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
67 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
68 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
69 Vascular smooth muscle contraction 💬
 [1] NPR1 💬 Nesiritide 💬 Nesiritide [2] 46, 58 💬
70 Vascular smooth muscle contraction 💬
 [2] NPR1, NPR2 💬 Erythrityl tetranitrate 💬 Erythrityl tetranitrate [1] 46 💬
71 Vascular smooth muscle contraction 💬
 [1] NPR2 💬 Vosoritide 💬 Vosoritide [1] 276 💬
72 Vascular smooth muscle contraction 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
73 Vascular smooth muscle contraction 💬
 [4] PRKCD, PRKCE, PRKCH, PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
74 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Beraprost 💬 Beraprost [1] 86 💬
75 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Epoprostenol 💬 Epoprostenol [1] 86 💬
76 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
77 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Iloprost 💬 Iloprost [4] 51, 84, 85, 86 💬
78 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Ralinepag 💬 Ralinepag [1] 86 💬
79 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Selexipag 💬 Selexipag [5] 51, 70, 84, 86, 88 💬
80 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 Treprostinil 💬 Treprostinil [6] 51, 84, 85, 86, 88, 210 💬
81 Vascular smooth muscle contraction 💬
 [2] ROCK1, ROCK2 💬 Fasudil 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
82 Vascular smooth muscle contraction 💬
 [1] ROCK2 💬 Belumosudil 💬 Belumosudil [2] 51, 85 💬