Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Apelin signaling pathway 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Apelin signaling pathway 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Apelin signaling pathway 💬

[1] AGTR1 💬

Candesartan 💬

Candesartan

[2] 58, 67 💬

Apelin signaling pathway 💬

[1] AGTR1 💬

Candesartan cilexetil 💬

Candesartan cilexetil

[1] 67 💬

Apelin signaling pathway 💬

[1] AGTR1 💬

Irbesartan 💬

Irbesartan

[4] 66, 167, 168, 222 💬

Apelin signaling pathway 💬

[1] AGTR1 💬

Losartan 💬

Losartan

[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
36	Epidermolysis bullosa;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
167	Marfan syndrome;
179	Williams syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

Apelin signaling pathway 💬

[1] AGTR1 💬

Sparsentan 💬

Sparsentan

[3] 66, 218, 222 💬

Apelin signaling pathway 💬

[1] AGTR1 💬

Telmisartan 💬

Telmisartan

[2] 66, 67 💬

Apelin signaling pathway 💬

[1] AGTR1 💬

Valsartan 💬

Valsartan

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Apelin signaling pathway 💬

[1] CCN2 💬

Pamrevlumab 💬

Pamrevlumab

[2] 85, 113 💬

Apelin signaling pathway 💬

[2] HDAC4, HDAC5 💬

Vorinostat 💬

Vorinostat

[2] 75, 96 💬

Apelin signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

Apelin signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

Apelin signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

Apelin signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

Apelin signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Apelin signaling pathway 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

Apelin signaling pathway 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Apelin signaling pathway 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Bucladesine 💬

Bucladesine

[1] 246 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Apelin signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Apelin signaling pathway 💬

[1] PDE3B 💬

Cilostazol 💬

Cilostazol

[3] 46, 51, 70 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Flavoxate 💬

Flavoxate

[1] 226 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Levosimendan 💬

Levosimendan

[1] 2 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Milrinone 💬

Milrinone

[1] 294 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Apelin signaling pathway 💬

[1] PDE3B 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Apelin signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Apelin signaling pathway 💬

[1] PRKCE 💬

Sotrastaurin 💬

Sotrastaurin

[1] 97 💬

Apelin signaling pathway 💬

[1] RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬