Gene

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Signaling pathways regulating pluripotency of stem cells 💬

[1] FGFR2 💬

Palifermin 💬

Palifermin

[5] 13, 36, 38, 39, 65 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
65	Primary immunodeficiency;

Signaling pathways regulating pluripotency of stem cells 💬

[1] IGF1R 💬

Linsitinib 💬

Linsitinib

[1] 232 💬

Signaling pathways regulating pluripotency of stem cells 💬

[1] IGF1R 💬

Mecasermin 💬

Mecasermin

[6] 65, 78, 96, 168, 265, 299 💬

Signaling pathways regulating pluripotency of stem cells 💬

[1] IGF1R 💬

Teprotumumab 💬

Teprotumumab

[1] 51 💬

Signaling pathways regulating pluripotency of stem cells 💬

[1] JAK1 💬

Abrocitinib 💬

Abrocitinib

[1] 84 💬

Signaling pathways regulating pluripotency of stem cells 💬

[1] JAK1 💬

Filgotinib 💬

Filgotinib

[6] 46, 53, 96, 97, 222, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
222	Primary nephrotic syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Signaling pathways regulating pluripotency of stem cells 💬

[1] JAK1 💬

Itacitinib 💬

Itacitinib

[4] 46, 51, 97, 228 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
97	Ulcerative colitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Signaling pathways regulating pluripotency of stem cells 💬

[1] JAK1 💬

Upadacitinib 💬

Upadacitinib

[8] 40, 41, 46, 49, 96, 97, 107, 271 💬

Disease ID	Name
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Signaling pathways regulating pluripotency of stem cells 💬

[2] JAK1, JAK2 💬

Baricitinib 💬

Baricitinib

[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
265	Lipodystrophy;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
325	Hereditary autoinflammatory syndrome;

Signaling pathways regulating pluripotency of stem cells 💬

[2] JAK1, JAK2 💬

Ruxolitinib 💬

Ruxolitinib

[3] 60, 65, 228 💬

Signaling pathways regulating pluripotency of stem cells 💬

[3] JAK1, JAK2, JAK3 💬

Peficitinib 💬

Peficitinib

[1] 46 💬

Signaling pathways regulating pluripotency of stem cells 💬

[3] JAK1, JAK2, JAK3 💬

Tofacitinib 💬

Tofacitinib

[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
65	Primary immunodeficiency;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

Signaling pathways regulating pluripotency of stem cells 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

Signaling pathways regulating pluripotency of stem cells 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

Signaling pathways regulating pluripotency of stem cells 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

Signaling pathways regulating pluripotency of stem cells 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

Signaling pathways regulating pluripotency of stem cells 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Signaling pathways regulating pluripotency of stem cells 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

Signaling pathways regulating pluripotency of stem cells 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

Signaling pathways regulating pluripotency of stem cells 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

Signaling pathways regulating pluripotency of stem cells 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Signaling pathways regulating pluripotency of stem cells 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Signaling pathways regulating pluripotency of stem cells 💬

[1] RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬