Gene

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
109	Atypical hemolytic uremic syndrome;aHUS;
222	Primary nephrotic syndrome;

Complement and coagulation cascades 💬

[1] C5 💬

Nomacopan 💬

Nomacopan

[3] 62, 109, 162 💬

Complement and coagulation cascades 💬

[1] C5 💬

Pozelimab 💬

Pozelimab

[2] 11, 62 💬

Complement and coagulation cascades 💬

[1] C5 💬

Ravulizumab 💬

Ravulizumab

[7] 2 , 11, 13, 50, 62, 66, 109 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
50	Dermatomyositis;Polymyositis;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
109	Atypical hemolytic uremic syndrome;aHUS;

Complement and coagulation cascades 💬

[1] C5 💬

Vilobelimab 💬

Vilobelimab

[3] 43, 44, 269 💬

Disease ID	Name
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;

Complement and coagulation cascades 💬

[1] C5 💬

Zilucoplan 💬

Zilucoplan

[3] 2 , 11, 62 💬

Complement and coagulation cascades 💬

[1] C5AR1 💬

Avacopan 💬

Avacopan

[3] 43, 44, 222 💬

Complement and coagulation cascades 💬

[1] CFB 💬

Iptacopan 💬

Iptacopan

[5] 61, 62, 66, 109, 222 💬

Disease ID	Name
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
109	Atypical hemolytic uremic syndrome;aHUS;
222	Primary nephrotic syndrome;

Complement and coagulation cascades 💬

[1] CFD 💬

Danicopan 💬

Danicopan

[1] 62 💬

Complement and coagulation cascades 💬

[1] F10 💬

Apixaban 💬

Apixaban

[1] 222 💬

Complement and coagulation cascades 💬

[1] F10 💬

Edoxaban 💬

Edoxaban

[2] 46, 88 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Complement and coagulation cascades 💬

[1] F10 💬

Rivaroxaban 💬

Rivaroxaban

[4] 46, 49, 91, 210 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
91	Budd-Chiari syndrome;BCS;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Complement and coagulation cascades 💬

[2] F10, F9 💬

Emicizumab 💬

Emicizumab

[1] 288 💬

Complement and coagulation cascades 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Complement and coagulation cascades 💬

[1] F2 💬

Dabigatran etexilate 💬

Dabigatran etexilate

[2] 51, 75 💬

Complement and coagulation cascades 💬

[1] F2 💬

Thrombomodulin alfa 💬

Thrombomodulin Alfa

[1] 85 💬

Complement and coagulation cascades 💬

[1] F8 💬

Desmopressin 💬

Desmopressin

[6] 6 , 64, 72, 75, 225, 288 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
64	Thrombotic thrombocytopenic purpura;TTP;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
75	Cushing disease;Cushing;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;

Complement and coagulation cascades 💬

[1] MASP2 💬

Narsoplimab 💬

Narsoplimab

[4] 64, 66, 109, 222 💬

Complement and coagulation cascades 💬

[1] PLG 💬

Aminocaproic acid 💬

Aminocaproic acid

[1] 70 💬

Complement and coagulation cascades 💬

[1] PLG 💬

Tranexamic acid 💬

Tranexamic acid

[7] 46, 70, 215, 227, 274, 288, 299 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
215	Tetralogy of Fallot;Fallot tetralogy;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
274	Osteogenesis Imperfecta;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
299	Cystic fibrosis;

Complement and coagulation cascades 💬

[1] SERPINC1 💬

Adomiparin 💬

Enoxaparin

[1] 46 💬

Complement and coagulation cascades 💬

[1] SERPINC1 💬

Adomiparin 💬

Heparin

[11] 47, 60, 70, 84, 107, 224, 226, 280, 299, 316, 317 💬

Disease ID	Name
47	Buerger disease;Thromboangiitis obliterans;
60	Aplastic anemia;
70	Spinal stenosis;Extensive spinal canal stenosis;
84	Sarcoidosis;
107	Juvenile idiopathic arthritis;JIA;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
299	Cystic fibrosis;
316	Carnitine cycle disorder;
317	Trifunctional protein deficiency;TFP deficiency;

Complement and coagulation cascades 💬

[1] SERPINC1 💬

Adomiparin 💬

Parnaparin

[1] 97 💬

Complement and coagulation cascades 💬

[2] SERPINC1, SERPIND1 💬

Sulodexide 💬

Sulodexide

[2] 51, 271 💬

Complement and coagulation cascades 💬

[1] VWF 💬

Caplacizumab 💬

Caplacizumab

[1] 64 💬