Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 TNF signaling pathway 💬
 [4] CCL2, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
2 TNF signaling pathway 💬
 [1] CSF2 💬 Otilimab 💬 Otilimab [1] 46 💬
3 TNF signaling pathway 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
4 TNF signaling pathway 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
5 TNF signaling pathway 💬
 [1] IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
6 TNF signaling pathway 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
7 TNF signaling pathway 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
8 TNF signaling pathway 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
9 TNF signaling pathway 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
10 TNF signaling pathway 💬
 [1] LTA 💬 Pateclizumab 💬 Pateclizumab [1] 46 💬
11 TNF signaling pathway 💬
 [2] LTA, TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
12 TNF signaling pathway 💬
 [1] MAP2K1 💬 Binimetinib 💬 Binimetinib [1] 34 💬
13 TNF signaling pathway 💬
 [1] MAP2K1 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
14 TNF signaling pathway 💬
 [1] MAP2K1 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
15 TNF signaling pathway 💬
 [1] MAP2K1 💬 Selumetinib 💬 Selumetinib [1] 34 💬
16 TNF signaling pathway 💬
 [1] MAP2K1 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
17 TNF signaling pathway 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
18 TNF signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
19 TNF signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
20 TNF signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
21 TNF signaling pathway 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
22 TNF signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
23 TNF signaling pathway 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
24 TNF signaling pathway 💬
 [1] PTGS2 💬 Aceclofenac 💬 Aceclofenac [1] 46 💬
25 TNF signaling pathway 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
26 TNF signaling pathway 💬
 [1] PTGS2 💬 Aspirin 💬 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
27 TNF signaling pathway 💬
 [1] PTGS2 💬 Celecoxib 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
28 TNF signaling pathway 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
29 TNF signaling pathway 💬
 [1] PTGS2 💬 Diflunisal 💬 Diflunisal [1] 28 💬
30 TNF signaling pathway 💬
 [1] PTGS2 💬 Etodolac 💬 Etodolac [1] 46 💬
31 TNF signaling pathway 💬
 [1] PTGS2 💬 Etoricoxib 💬 Etoricoxib [2] 46, 271 💬
32 TNF signaling pathway 💬
 [1] PTGS2 💬 Flurbiprofen 💬 Flurbiprofen [3] 13, 21, 46 💬
33 TNF signaling pathway 💬
 [1] PTGS2 💬 Ibuprofen 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
34 TNF signaling pathway 💬
 [1] PTGS2 💬 Indomethacin 💬 Indomethacin [3] 225, 271, 298 💬
35 TNF signaling pathway 💬
 [1] PTGS2 💬 Ketoprofen 💬 Ketoprofen [1] 46 💬
36 TNF signaling pathway 💬
 [1] PTGS2 💬 Ketorolac 💬 Ketorolac [2] 70, 226 💬
37 TNF signaling pathway 💬
 [1] PTGS2 💬 Loxoprofen 💬 Loxoprofen [2] 46, 271 💬
38 TNF signaling pathway 💬
 [1] PTGS2 💬 Lumiracoxib 💬 Lumiracoxib [1] 46 💬
39 TNF signaling pathway 💬
 [1] PTGS2 💬 Meloxicam 💬 Meloxicam [4] 46, 49, 271, 296 💬
40 TNF signaling pathway 💬
 [1] PTGS2 💬 Naproxen 💬 Naproxen [4] 13, 46, 107, 271 💬
41 TNF signaling pathway 💬
 [1] PTGS2 💬 Nimesulide 💬 Nimesulide [1] 46 💬
42 TNF signaling pathway 💬
 [1] PTGS2 💬 Parecoxib 💬 Parecoxib [2] 46, 271 💬
43 TNF signaling pathway 💬
 [1] PTGS2 💬 Rofecoxib 💬 Rofecoxib [1] 46 💬
44 TNF signaling pathway 💬
 [1] PTGS2 💬 Salsalate 💬 Salsalate [1]  5  💬
45 TNF signaling pathway 💬
 [1] PTGS2 💬 Sulindac 💬 Sulindac [1] 206 💬
46 TNF signaling pathway 💬
 [1] PTGS2 💬 Tolfenamic acid 💬 Tolfenamic acid [1]  5  💬
47 TNF signaling pathway 💬
 [1] PTGS2 💬 Valdecoxib 💬 Valdecoxib [1] 46 💬
48 TNF signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
49 TNF signaling pathway 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
50 TNF signaling pathway 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
51 TNF signaling pathway 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
52 TNF signaling pathway 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
53 TNF signaling pathway 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
54 TNF signaling pathway 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
55 TNF signaling pathway 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
56 TNF signaling pathway 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬