Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Serotonergic synapse 💬
 [1] ALOX5 💬 Oxatomide 💬 Oxatomide [1] 113 💬
2 Serotonergic synapse 💬
 [1] ALOX5 💬 Zileuton 💬 Zileuton [3] 85, 160, 164 💬
3 Serotonergic synapse 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
4 Serotonergic synapse 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
5 Serotonergic synapse 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
6 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
7 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
8 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
9 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
10 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
11 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
12 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
13 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
14 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
15 Serotonergic synapse 💬
 [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
16 Serotonergic synapse 💬
 [1] DDC 💬 Benserazide 💬 Benserazide [1]  6  💬
17 Serotonergic synapse 💬
 [1] DDC 💬 Carbidopa 💬 Carbidopa [7]  6 , 13, 17, 90, 140, 164, 201 💬
18 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Alprazolam 💬 Alprazolam [2]  8 , 75 💬
19 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Brexanolone 💬 Brexanolone [1] 205 💬
20 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Clobazam 💬 Clobazam [2] 140, 144 💬
21 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Clonazepam 💬 Clonazepam [1]  6  💬
22 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Delorazepam 💬 Delorazepam [3]  6 , 46, 97 💬
23 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Diazepam 💬 Diazepam [3] 46, 155, 298 💬
24 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Eszopiclone 💬 Eszopiclone [3]  6 , 13, 46 💬
25 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
26 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Gaboxadol 💬 Gaboxadol [2] 201, 206 💬
27 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
28 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Lorazepam 💬 Lorazepam [1] 36 💬
29 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Midazolam 💬 Midazolam [12]  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
30 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Propofol 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
31 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Zolpidem 💬 Zolpidem [3]  5 ,  6 , 46 💬
32 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Zopiclone 💬 Zopiclone [1]  6  💬
33 Serotonergic synapse 💬
 [1] HTR1A 💬 Buspirone 💬 Buspirone [2]  6 , 51 💬
34 Serotonergic synapse 💬
 [1] HTR1A 💬 Pardoprunox 💬 Pardoprunox [1]  6  💬
35 Serotonergic synapse 💬
 [2] HTR1A, HTR2A 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
36 Serotonergic synapse 💬
 [2] HTR1A, HTR2A 💬 Cariprazine 💬 Cariprazine [1] 21 💬
37 Serotonergic synapse 💬
 [7] HTR1A, HTR3A, HTR3B, HTR3C, HTR3D, HTR3E, SLC6A4 💬 Vortioxetine 💬 Vortioxetine [1]  6  💬
38 Serotonergic synapse 💬
 [2] HTR1B, HTR1D 💬 Zolmitriptan 💬 Zolmitriptan [1]  6  💬
39 Serotonergic synapse 💬
 [4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
40 Serotonergic synapse 💬
 [1] HTR2A 💬 Nelotanserin 💬 Nelotanserin [1]  6  💬
41 Serotonergic synapse 💬
 [1] HTR2A 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
42 Serotonergic synapse 💬
 [1] HTR2A 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
43 Serotonergic synapse 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
44 Serotonergic synapse 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Iloperidone 💬 Iloperidone [1]  6  💬
45 Serotonergic synapse 💬
 [4] HTR2A, HTR2B, HTR2C, HTR6 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
46 Serotonergic synapse 💬
 [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 Trazodone 💬 Trazodone [1]  2  💬
47 Serotonergic synapse 💬
 [7] HTR2A, HTR2C, HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 Clozapine 💬 Clozapine [1]  6  💬
48 Serotonergic synapse 💬
 [3] HTR2A, HTR3A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬
49 Serotonergic synapse 💬
 [3] HTR2A, HTR3A, HTR4 💬 Cisapride 💬 Cisapride [1] 13 💬
50 Serotonergic synapse 💬
 [1] HTR2C 💬 Agomelatine 💬 Agomelatine [1]  6  💬
51 Serotonergic synapse 💬
 [5] HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 Dolasetron 💬 Dolasetron [1] 46 💬
52 Serotonergic synapse 💬
 [5] HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 Ondansetron 💬 Ondansetron [3]  6 , 97, 107 💬
53 Serotonergic synapse 💬
 [1] HTR4 💬 Mosapride 💬 Mosapride [1] 96 💬
54 Serotonergic synapse 💬
 [1] HTR4 💬 Prucalopride 💬 Prucalopride [3] 13, 51, 96 💬
55 Serotonergic synapse 💬
 [1] HTR4 💬 Velusetrag 💬 Velusetrag [1] 99 💬
56 Serotonergic synapse 💬
 [1] KCND2 💬 Amifampridine 💬 Amifampridine [3]  3 , 11, 12 💬
57 Serotonergic synapse 💬
 [1] KCND2 💬 Dalfampridine 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
58 Serotonergic synapse 💬
 [2] KCNJ3, KCNJ5 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
59 Serotonergic synapse 💬
 [1] MAOA 💬 Moclobemide 💬 Moclobemide [1]  6  💬
60 Serotonergic synapse 💬
 [2] MAOA, MAOB 💬 Iproniazid 💬 Iproniazid [1]  6  💬
61 Serotonergic synapse 💬
 [2] MAOA, MAOB 💬 Phenelzine 💬 Phenelzine [1]  6  💬
62 Serotonergic synapse 💬
 [3] MAOA, MAOB, SLC6A4 💬 Phentermine 💬 Phentermine [1] 97 💬
63 Serotonergic synapse 💬
 [1] MAOB 💬 Rasagiline 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
64 Serotonergic synapse 💬
 [1] MAOB 💬 Rasagiline tartrate 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
65 Serotonergic synapse 💬
 [1] MAOB 💬 Safinamide 💬 Safinamide [2]  6 , 17 💬
66 Serotonergic synapse 💬
 [1] MAOB 💬 Selegiline 💬 Selegiline [1]  6  💬
67 Serotonergic synapse 💬
 [1] MAP2K1 💬 Binimetinib 💬 Binimetinib [1] 34 💬
68 Serotonergic synapse 💬
 [1] MAP2K1 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
69 Serotonergic synapse 💬
 [1] MAP2K1 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
70 Serotonergic synapse 💬
 [1] MAP2K1 💬 Selumetinib 💬 Selumetinib [1] 34 💬
71 Serotonergic synapse 💬
 [1] MAP2K1 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
72 Serotonergic synapse 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
73 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Aceclofenac 💬 Aceclofenac [1] 46 💬
74 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
75 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Aspirin 💬 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
76 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
77 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Flurbiprofen 💬 Flurbiprofen [3] 13, 21, 46 💬
78 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Ibuprofen 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
79 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Indomethacin 💬 Indomethacin [3] 225, 271, 298 💬
80 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Ketoprofen 💬 Ketoprofen [1] 46 💬
81 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Ketorolac 💬 Ketorolac [2] 70, 226 💬
82 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Loxoprofen 💬 Loxoprofen [2] 46, 271 💬
83 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Naproxen 💬 Naproxen [4] 13, 46, 107, 271 💬
84 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Salsalate 💬 Salsalate [1]  5  💬
85 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Sulindac 💬 Sulindac [1] 206 💬
86 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Tolfenamic acid 💬 Tolfenamic acid [1]  5  💬
87 Serotonergic synapse 💬
 [1] PTGS2 💬 Celecoxib 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
88 Serotonergic synapse 💬
 [1] PTGS2 💬 Diflunisal 💬 Diflunisal [1] 28 💬
89 Serotonergic synapse 💬
 [1] PTGS2 💬 Etodolac 💬 Etodolac [1] 46 💬
90 Serotonergic synapse 💬
 [1] PTGS2 💬 Etoricoxib 💬 Etoricoxib [2] 46, 271 💬
91 Serotonergic synapse 💬
 [1] PTGS2 💬 Lumiracoxib 💬 Lumiracoxib [1] 46 💬
92 Serotonergic synapse 💬
 [1] PTGS2 💬 Meloxicam 💬 Meloxicam [4] 46, 49, 271, 296 💬
93 Serotonergic synapse 💬
 [1] PTGS2 💬 Nimesulide 💬 Nimesulide [1] 46 💬
94 Serotonergic synapse 💬
 [1] PTGS2 💬 Parecoxib 💬 Parecoxib [2] 46, 271 💬
95 Serotonergic synapse 💬
 [1] PTGS2 💬 Rofecoxib 💬 Rofecoxib [1] 46 💬
96 Serotonergic synapse 💬
 [1] PTGS2 💬 Valdecoxib 💬 Valdecoxib [1] 46 💬
97 Serotonergic synapse 💬
 [1] SLC18A2 💬 Deutetrabenazine 💬 Deutetrabenazine [1]  8  💬
98 Serotonergic synapse 💬
 [1] SLC18A2 💬 Tetrabenazine 💬 Tetrabenazine [1]  8  💬
99 Serotonergic synapse 💬
 [1] SLC18A2 💬 Valbenazine 💬 Valbenazine [1]  8  💬
100 Serotonergic synapse 💬
 [1] SLC6A4 💬 Amitriptyline 💬 Amitriptyline [4] 78, 97, 226, 299 💬
101 Serotonergic synapse 💬
 [1] SLC6A4 💬 Amoxapine 💬 Amoxapine [1] 46 💬
102 Serotonergic synapse 💬
 [1] SLC6A4 💬 Ampreloxetine 💬 Ampreloxetine [2]  6 , 17 💬
103 Serotonergic synapse 💬
 [1] SLC6A4 💬 Citalopram 💬 Citalopram [7]  6 ,  8 , 13, 18, 46, 98, 127 💬
104 Serotonergic synapse 💬
 [1] SLC6A4 💬 Desipramine 💬 Desipramine [2] 120, 156 💬
105 Serotonergic synapse 💬
 [1] SLC6A4 💬 Doxepin 💬 Doxepin [1]  6  💬
106 Serotonergic synapse 💬
 [1] SLC6A4 💬 Duloxetine 💬 Duloxetine [2]  6 , 13 💬
107 Serotonergic synapse 💬
 [1] SLC6A4 💬 Escitalopram 💬 Escitalopram [4]  2 ,  6 , 13, 46 💬
108 Serotonergic synapse 💬
 [1] SLC6A4 💬 Fluoxetine 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
109 Serotonergic synapse 💬
 [1] SLC6A4 💬 Milnacipran 💬 Milnacipran [2] 46, 49 💬
110 Serotonergic synapse 💬
 [1] SLC6A4 💬 Nortriptyline 💬 Nortriptyline [2]  6 , 226 💬
111 Serotonergic synapse 💬
 [1] SLC6A4 💬 Paroxetine 💬 Paroxetine [4]  6 , 13, 46, 85 💬
112 Serotonergic synapse 💬
 [1] SLC6A4 💬 Sertraline 💬 Sertraline [2]  6 , 206 💬
113 Serotonergic synapse 💬
 [1] SLC6A4 💬 Venlafaxine 💬 Venlafaxine [3]  6 , 13, 46 💬
114 Serotonergic synapse 💬
 [2] TPH1, TPH2 💬 Telotristat 💬 Telotristat [1] 97 💬