Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Endocrine and other factor-regulated calcium reabsorption 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digitoxin 💬

Digitoxin

[1] 299 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Clomifene 💬

Clomifene

[1] 74 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Danazol 💬

Danazol

[5] 60, 63, 64, 65, 285 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Desogestrel 💬

Desogestrel

[1] 230 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estetrol 💬

Estetrol

[1] 53 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estetrol 💬

Estetrol

[1] 53 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estradiol 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

Estradiol

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estriol 💬

Estriol

[2] 13, 227 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estriol tripropionate 💬

Estriol

[2] 13, 227 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Fulvestrant 💬

Fulvestrant

[2] 49, 86 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Mestranol 💬

Mestranol

[2] 46, 49 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Prasterone 💬

Prasterone

[6] 49, 53, 83, 86, 96, 113 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Raloxifene 💬

Raloxifene

[1] 46 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Tamoxifen 💬

Tamoxifen

[3] 2 , 113, 227 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PTH1R 💬

Parathyroid hormone 💬

Parathyroid hormone

[4] 65, 70, 235, 326 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PTH1R 💬

Teriparatide 💬

Teriparatide

[7] 46, 65, 68, 70, 71, 235, 274 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
68	Ossification of the ligamentum flavum;Ossification of ligamentum flavum;OLF;
70	Spinal stenosis;Extensive spinal canal stenosis;
71	Idiopathic osteonecrosis of the femoral head;Idiopathic femoral head necrosis;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
274	Osteogenesis Imperfecta;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Alfacalcidol 💬

Alfacalcidol

[8] 41, 46, 49, 50, 96, 107, 235, 238 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
96	Crohn disease;Terminal ileitis;
107	Juvenile idiopathic arthritis;JIA;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
238	Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Calcifediol 💬

Calcifediol

[2] 113, 299 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Calcipotriene 💬

Calcipotriol

[2] 36, 51 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Calcitriol 💬

Calcitriol

[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
326	Osteopetrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Cholecalciferol 💬

Cholecalciferol

[24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
65	Primary immunodeficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
162	Pemphigoid;
202	Smith-Magenis syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Dihydrotachysterol 💬

Dihydrotachysterol

[2] 6 , 85 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Eldecalcitol 💬

Eldecalcitol

[1] 46 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Ergocalciferol 💬

Ergocalciferol

[6] 46, 49, 84, 96, 97, 299 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
299	Cystic fibrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Paricalcitol 💬

Paricalcitol

[5] 19, 66, 218, 238, 298 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
218	Alport syndrome;
238	Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;
298	Hereditary pancreatitis;Chronic pancreatitis;