Gene

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Amphetamine addiction 💬

[1] DDC 💬

Benserazide 💬

Benserazide

[1] 6 💬

Amphetamine addiction 💬

[1] DDC 💬

Carbidopa 💬

Carbidopa

[7] 6 , 13, 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
90	Retinitis pigmentosa;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;
201	Angelman syndrome;

Amphetamine addiction 💬

[1] DRD1 💬

Apomorphine 💬

Apomorphine

[3] 5 , 6 , 7 💬

Amphetamine addiction 💬

[1] DRD1 💬

Dexpramipexole 💬

Dexpramipexole

[1] 2 💬

Amphetamine addiction 💬

[1] DRD1 💬

Dopamine 💬

Dopamine

[4] 6 , 7 , 74, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
7	Corticobasal degeneration;Corticobasal syndrome;CBD;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
299	Cystic fibrosis;

Amphetamine addiction 💬

[1] DRD1 💬

Flupentixol 💬

Flupentixol

[1] 97 💬

Amphetamine addiction 💬

[1] DRD1 💬

Foslevodopa 💬

Foslevodopa

[1] 6 💬

Amphetamine addiction 💬

[1] DRD1 💬

Levodopa 💬

Levodopa

[6] 6 , 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
90	Retinitis pigmentosa;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;
201	Angelman syndrome;

Amphetamine addiction 💬

[1] DRD1 💬

Pergolide 💬

Pergolide

[1] 6 💬

Amphetamine addiction 💬

[1] DRD1 💬

Tavapadon 💬

Tavapadon

[1] 6 💬

Amphetamine addiction 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Perampanel 💬

Perampanel

[3] 2 , 6 , 144 💬

Amphetamine addiction 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Talampanel 💬

Talampanel

[2] 2 , 6 💬

Amphetamine addiction 💬

[9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Riluzole 💬

Riluzole

[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
18	Spinocerebellar degeneration;SCD;
203	22q11.2 deletion syndrome;
206	Fragile X syndrome;

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Acamprosate 💬

Acamprosate

[2] 6 , 206 💬

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Amantadine 💬

Amantadine

[4] 6 , 8 , 13, 127 💬

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Esketamine 💬

Esketamine

[3] 2 , 4 , 70 💬

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Ketamine 💬

Ketamine

[8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
4	Primary lateral sclerosis;PLS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
70	Spinal stenosis;Extensive spinal canal stenosis;
113	Muscular dystrophy;
156	Rett syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Latrepirdine 💬

Latrepirdine

[1] 8 💬

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Memantine 💬

Memantine

[8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
49	Systemic lupus erythematosus;SLE;
127	Frontotemporal lobar degeneration;
205	Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;
206	Fragile X syndrome;

Amphetamine addiction 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

Vorinostat

[2] 75, 96 💬

Amphetamine addiction 💬

[1] MAOA 💬

Moclobemide 💬

Moclobemide

[1] 6 💬

Amphetamine addiction 💬

[2] MAOA, MAOB 💬

Iproniazid 💬

Iproniazid

[1] 6 💬

Amphetamine addiction 💬

[2] MAOA, MAOB 💬

Phenelzine 💬

Phenelzine

[1] 6 💬

Amphetamine addiction 💬

[3] MAOA, MAOB, SLC6A3 💬

Phentermine 💬

Phentermine

[1] 97 💬

Amphetamine addiction 💬

[1] MAOB 💬

Rasagiline 💬

Rasagiline

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

Amphetamine addiction 💬

[1] MAOB 💬

Rasagiline tartrate 💬

Rasagiline

[6] 2 , 5 , 6 , 17, 58, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

Amphetamine addiction 💬

[1] MAOB 💬

Safinamide 💬

Safinamide

[2] 6 , 17 💬

Amphetamine addiction 💬

[1] MAOB 💬

Selegiline 💬

Selegiline

[1] 6 💬

Amphetamine addiction 💬

[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬

Name	Full Name
PPP3CA	protein phosphatase 3 catalytic subunit alpha
PPP3CB	protein phosphatase 3 catalytic subunit beta
PPP3CC	protein phosphatase 3 catalytic subunit gamma
PPP3R1	protein phosphatase 3 regulatory subunit B, alpha
PPP3R2	protein phosphatase 3 regulatory subunit B, beta

Cyclosporine 💬

Cyclosporine

[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
58	Hypertrophic cardiomyopathy;HCM;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
64	Thrombotic thrombocytopenic purpura;TTP;
65	Primary immunodeficiency;
90	Retinitis pigmentosa;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
162	Pemphigoid;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
274	Osteogenesis Imperfecta;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
302	Leber hereditary optic neuropathy;
326	Osteopetrosis;

Amphetamine addiction 💬

[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬

Name	Full Name
PPP3CA	protein phosphatase 3 catalytic subunit alpha
PPP3CB	protein phosphatase 3 catalytic subunit beta
PPP3CC	protein phosphatase 3 catalytic subunit gamma
PPP3R1	protein phosphatase 3 regulatory subunit B, alpha
PPP3R2	protein phosphatase 3 regulatory subunit B, beta

Pimecrolimus 💬

Pimecrolimus

[1] 160 💬

Amphetamine addiction 💬

[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬

Name	Full Name
PPP3CA	protein phosphatase 3 catalytic subunit alpha
PPP3CB	protein phosphatase 3 catalytic subunit beta
PPP3CC	protein phosphatase 3 catalytic subunit gamma
PPP3R1	protein phosphatase 3 regulatory subunit B, alpha
PPP3R2	protein phosphatase 3 regulatory subunit B, beta

Tacrolimus 💬

Tacrolimus

[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
113	Muscular dystrophy;
151	Rasmussen encephalitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
299	Cystic fibrosis;

Amphetamine addiction 💬

[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬

Name	Full Name
PPP3CA	protein phosphatase 3 catalytic subunit alpha
PPP3CB	protein phosphatase 3 catalytic subunit beta
PPP3CC	protein phosphatase 3 catalytic subunit gamma
PPP3R1	protein phosphatase 3 regulatory subunit B, alpha
PPP3R2	protein phosphatase 3 regulatory subunit B, beta

Tacrolimus 💬

Tacrolimus

[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
113	Muscular dystrophy;
151	Rasmussen encephalitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
224	Purpura nephritis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
299	Cystic fibrosis;

Amphetamine addiction 💬

[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬

Name	Full Name
PPP3CA	protein phosphatase 3 catalytic subunit alpha
PPP3CB	protein phosphatase 3 catalytic subunit beta
PPP3CC	protein phosphatase 3 catalytic subunit gamma
PPP3R1	protein phosphatase 3 regulatory subunit B, alpha
PPP3R2	protein phosphatase 3 regulatory subunit B, beta

Voclosporin 💬

Voclosporin

[2] 49, 222 💬

Amphetamine addiction 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Amphetamine addiction 💬

[1] SLC18A2 💬

Deutetrabenazine 💬

Deutetrabenazine

[1] 8 💬

Amphetamine addiction 💬

[1] SLC18A2 💬

Tetrabenazine 💬

Tetrabenazine

[1] 8 💬

Amphetamine addiction 💬

[1] SLC18A2 💬

Valbenazine 💬

Valbenazine

[1] 8 💬

Amphetamine addiction 💬

[1] SLC6A3 💬

Armodafinil 💬

Armodafinil

[3] 6 , 13, 84 💬

Amphetamine addiction 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

Amphetamine addiction 💬

[1] SLC6A3 💬

Lisdexamfetamine 💬

Lisdexamfetamine

[1] 13 💬

Amphetamine addiction 💬

[1] SLC6A3 💬

Methylphenidate 💬

Methylphenidate

[7] 6 , 13, 34, 84, 113, 179, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
84	Sarcoidosis;
113	Muscular dystrophy;
179	Williams syndrome;
206	Fragile X syndrome;