Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Transcriptional misregulation in cancer 💬
 [1] CD40 💬 Bleselumab 💬 Bleselumab [1] 222 💬
2 Transcriptional misregulation in cancer 💬
 [1] CD40 💬 Iscalimab 💬 Iscalimab [2] 49, 53 💬
3 Transcriptional misregulation in cancer 💬
 [1] CD40 💬 Ravagalimab 💬 Ravagalimab [2] 53, 97 💬
4 Transcriptional misregulation in cancer 💬
 [1] CD86 💬 Abatacept 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
5 Transcriptional misregulation in cancer 💬
 [1] CD86 💬 Belatacept 💬 Belatacept [1] 46 💬
6 Transcriptional misregulation in cancer 💬
 [3] CSF1R, FLT1, FLT3 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
7 Transcriptional misregulation in cancer 💬
 [2] CSF1R, FLT3 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬
8 Transcriptional misregulation in cancer 💬
 [1] CSF2 💬 Otilimab 💬 Otilimab [1] 46 💬
9 Transcriptional misregulation in cancer 💬
 [1] ELANE 💬 Sivelestat 💬 Sivelestat [3] 13, 85, 96 💬
10 Transcriptional misregulation in cancer 💬
 [1] FLT1 💬 Axitinib 💬 Axitinib [1] 34 💬
11 Transcriptional misregulation in cancer 💬
 [1] FLT1 💬 Cediranib 💬 Cediranib [1] 34 💬
12 Transcriptional misregulation in cancer 💬
 [1] FLT1 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
13 Transcriptional misregulation in cancer 💬
 [1] FLT3 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
14 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
15 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
16 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
17 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
18 Transcriptional misregulation in cancer 💬
 [2] HDAC1, HDAC2 💬 Vorinostat 💬 Vorinostat [2] 75, 96 💬
19 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
20 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
21 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 Teprotumumab 💬 Teprotumumab [1] 51 💬
22 Transcriptional misregulation in cancer 💬
 [1] IL1R2 💬 Anakinra 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
23 Transcriptional misregulation in cancer 💬
 [1] IL2RB 💬 Aldesleukin 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
24 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
25 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
26 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
27 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
28 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
29 Transcriptional misregulation in cancer 💬
 [1] ITGB7 💬 Abrilumab 💬 Abrilumab [2] 96, 97 💬
30 Transcriptional misregulation in cancer 💬
 [1] ITGB7 💬 Etrolizumab 💬 Etrolizumab [2] 96, 97 💬
31 Transcriptional misregulation in cancer 💬
 [1] ITGB7 💬 Vedolizumab 💬 Vedolizumab [3] 94, 96, 97 💬
32 Transcriptional misregulation in cancer 💬
 [1] MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
33 Transcriptional misregulation in cancer 💬
 [1] MPO 💬 Verdiperstat 💬 Verdiperstat [3]  2 , 17, 127 💬
34 Transcriptional misregulation in cancer 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
35 Transcriptional misregulation in cancer 💬
 [1] NGFR 💬 Cenegermin 💬 Cenegermin [2] 53, 90 💬
36 Transcriptional misregulation in cancer 💬
 [2] PML, RARA 💬 Tretinoin 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
37 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 Bocidelpar 💬 Bocidelpar [1] 113 💬
38 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 Leriglitazone 💬 Leriglitazone [1] 20 💬
39 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
40 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 Rosiglitazone 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
41 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 Seladelpar 💬 Seladelpar [2] 93, 94 💬
42 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 Fenretinide 💬 Fenretinide [1] 299 💬
43 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 Isotretinoin 💬 Isotretinoin [4] 36, 39, 159, 160 💬
44 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 Tamibarotene 💬 Tamibarotene [2] 26, 96 💬
45 Transcriptional misregulation in cancer 💬
 [1] RARA 💬 Vitamin A 💬 Vitamin A [3] 13, 53, 90 💬
46 Transcriptional misregulation in cancer 💬
 [4] RARA, RXRA, RXRB, RXRG 💬 Acitretin 💬 Acitretin [1] 37 💬
47 Transcriptional misregulation in cancer 💬
 [4] RARA, RXRA, RXRB, RXRG 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬
48 Transcriptional misregulation in cancer 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
49 Transcriptional misregulation in cancer 💬
 [3] RXRA, RXRB, RXRG 💬 Bexarotene 💬 Bexarotene [2] 13, 75 💬