Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
2 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
3 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Bisoprolol 💬 Bisoprolol [4] 58, 67, 86, 113 💬
4 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Celiprolol 💬 Celiprolol [1] 168 💬
5 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Dobutamine 💬 Dobutamine [4] 57, 58, 86, 215 💬
6 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Esmolol 💬 Esmolol [1] 58 💬
7 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Metoprolol 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
8 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
9 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Carvedilol 💬 Carvedilol [4] 57, 86, 113, 210 💬
10 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Nadolol 💬 Nadolol [1]  6  💬
11 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Timolol 💬 Timolol [2] 157, 227 💬
12 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Timolol 💬 Timolol [2] 157, 227 💬
13 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin [1]  6  💬
14 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
15 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine [1] 11 💬
16 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine [3] 46, 70, 96 💬
17 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine [2] 22, 296 💬
18 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
19 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine [1] 17 💬
20 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬
21 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Formoterol 💬 Formoterol [3] 85, 228, 299 💬
22 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Isoxsuprine 💬 Isoxsuprine [1] 13 💬
23 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Levosalbutamol 💬 Levosalbutamol [1] 49 💬
24 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
25 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Salmeterol 💬 Salmeterol [1] 299 💬
26 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Terbutaline 💬 Terbutaline [1] 118 💬
27 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Tulobuterol 💬 Tulobuterol [1]  6  💬
28 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB3 💬 Mirabegron 💬 Mirabegron [4]  6 , 13, 53, 226 💬
29 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Calusterone 💬 Calusterone [1]  2  💬
30 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Flutamide 💬 Flutamide [1] 81 💬
31 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Nandrolone 💬 Nandrolone [2] 60, 85 💬
32 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate [2] 60, 85 💬
33 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
34 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Stanozolol 💬 Stanozolol [1] 60 💬
35 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
36 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone decanoate 💬 Testosterone decanoate [1] 113 💬
37 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone enanthate 💬 Testosterone enanthate [1] 113 💬
38 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate [1] 113 💬
39 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone propionate 💬 Testosterone propionate [1] 113 💬
40 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate [2] 13, 60 💬
41 Chemical carcinogenesis - receptor activation 💬
 [3] AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
42 Chemical carcinogenesis - receptor activation 💬
 [3] AR, ESR1, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
43 Chemical carcinogenesis - receptor activation 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
44 Chemical carcinogenesis - receptor activation 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
45 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
46 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
47 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
48 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
49 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
50 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
51 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
52 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
53 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
54 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
55 Chemical carcinogenesis - receptor activation 💬
 [6] CHRNA3, CHRNA4, CHRNA7, CHRNA9, CHRNB2, CHRNB4 💬 Nicotine 💬 Nicotine [3]  6 , 13, 84 💬
56 Chemical carcinogenesis - receptor activation 💬
 [2] CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline [3]  6 , 18, 53 💬
57 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
58 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
59 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
60 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
61 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
62 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
63 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
64 Chemical carcinogenesis - receptor activation 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
65 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
66 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
67 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
68 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
69 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
70 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
71 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
72 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
73 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
74 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
75 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
76 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, PGR 💬 Desogestrel 💬 Desogestrel [1] 230 💬
77 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
78 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬
79 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
80 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
81 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
82 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
83 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
84 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
85 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
86 Chemical carcinogenesis - receptor activation 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
87 Chemical carcinogenesis - receptor activation 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
88 Chemical carcinogenesis - receptor activation 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
89 Chemical carcinogenesis - receptor activation 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
90 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Dydrogesterone 💬 Dydrogesterone [1] 13 💬
91 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Levonorgestrel 💬 Levonorgestrel [1] 13 💬
92 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Medroxyprogesterone acetate 💬 Medroxyprogesterone acetate [8] 13, 35, 46, 49, 50, 51, 60, 107 💬
93 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Megestrol acetate 💬 Megestrol acetate [1] 76 💬
94 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Mifepristone 💬 Mifepristone [1] 75 💬
95 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Nomegestrol 💬 Nomegestrol [1] 13 💬
96 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Nomegestrol acetate 💬 Nomegestrol acetate [1] 13 💬
97 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Norethindrone 💬 Norethisterone [4] 13, 46, 49, 299 💬
98 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Norgestimate 💬 Norgestimate [1] 299 💬
99 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Progesterone 💬 Progesterone [2] 76, 299 💬
100 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Ulipristal 💬 Ulipristal [1] 10 💬
101 Chemical carcinogenesis - receptor activation 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
102 Chemical carcinogenesis - receptor activation 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
103 Chemical carcinogenesis - receptor activation 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
104 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Bezafibrate 💬 Bezafibrate [7] 20, 93, 94, 160, 296, 316, 324 💬
105 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Elafibranor 💬 Elafibranor [2] 93, 94 💬
106 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Fenofibrate 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
107 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Pemafibrate 💬 Pemafibrate [1] 93 💬
108 Chemical carcinogenesis - receptor activation 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
109 Chemical carcinogenesis - receptor activation 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
110 Chemical carcinogenesis - receptor activation 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
111 Chemical carcinogenesis - receptor activation 💬
 [3] RXRA, RXRB, RXRG 💬 Acitretin 💬 Acitretin [1] 37 💬
112 Chemical carcinogenesis - receptor activation 💬
 [3] RXRA, RXRB, RXRG 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬
113 Chemical carcinogenesis - receptor activation 💬
 [3] RXRA, RXRB, RXRG 💬 Bexarotene 💬 Bexarotene [2] 13, 75 💬
114 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
115 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
116 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
117 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
118 Chemical carcinogenesis - receptor activation 💬
 [1] TNFSF11 💬 Denosumab 💬 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299 💬
119 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Alfacalcidol 💬 Alfacalcidol [8] 41, 46, 49, 50, 96, 107, 235, 238 💬
120 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Calcifediol 💬 Calcifediol [2] 113, 299 💬
121 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Calcipotriene 💬 Calcipotriol [2] 36, 51 💬
122 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Calcitriol 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
123 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Cholecalciferol 💬 Cholecalciferol [24]  6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
124 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Dihydrotachysterol 💬 Dihydrotachysterol [2]  6 , 85 💬
125 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Eldecalcitol 💬 Eldecalcitol [1] 46 💬
126 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Ergocalciferol 💬 Ergocalciferol [6] 46, 49, 84, 96, 97, 299 💬
127 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Paricalcitol 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬
128 Chemical carcinogenesis - receptor activation 💬
 [1] VEGFA 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
129 Chemical carcinogenesis - receptor activation 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
130 Chemical carcinogenesis - receptor activation 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬