Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] ALK 💬 Brigatinib 💬 Brigatinib [1] 34 💬
2 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] ALK 💬 Crizotinib 💬 Crizotinib [1] 34 💬
3 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] CD274 💬 Atezolizumab 💬 Atezolizumab [1] 85 💬
4 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] CD274 💬 Durvalumab 💬 Durvalumab [1] 85 💬
5 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [3] CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab [1] 46 💬
6 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [3] CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab [2] 96, 97 💬
7 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab [1] 49 💬
8 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] CD4 💬 Zanolimumab 💬 Zanolimumab [1] 46 💬
9 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
10 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
11 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
12 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
13 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
14 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
15 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
16 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬
17 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬
18 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
19 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] JAK1 💬 Abrocitinib 💬 Abrocitinib [1] 84 💬
20 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] JAK1 💬 Filgotinib 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
21 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬
22 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] JAK1 💬 Upadacitinib 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
23 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] JAK1, JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
24 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] JAK1, JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬
25 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
26 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] JAK1, JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
27 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] LCK 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
28 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] LCK 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
29 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
30 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
31 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
32 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
33 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
34 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
35 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
36 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
37 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
38 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
39 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
40 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] PDCD1 💬 Nivolumab 💬 Nivolumab [12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
41 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] PDCD1 💬 Pembrolizumab 💬 Pembrolizumab [2] 25, 285 💬
42 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
43 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
44 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
45 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
46 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬
47 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
48 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
49 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬
50 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
51 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
52 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
53 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] TLR9 💬 Cobitolimod 💬 Cobitolimod [1] 97 💬