Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)2件: Abatacept,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Abatacept 💬 		4件: CD80,
CD86,
DHFR,
DHFR2 💬 		17件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecule (CAM) interaction, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, IgSF CAM signaling, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬1件: 46 💬
2Adalimumab with methotrexate2件: Adalimumab,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Adalimumab 💬 		3件: DHFR,
DHFR2,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
3AZATHIOPRINE or METHOTREXATE2件: Azathioprine,
Methotrexate (Methotrexate)		4件: Methotrexate (Methotrexate),
Azathioprine ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Azathioprine sodium 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 96 💬
4BMS-582949 and Methotrexate2件: BMS-582949,
Methotrexate (Methotrexate)		2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
5Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF4件: Busulfan,
Fludarabine,
Methotrexate (Methotrexate),
Tacrolimus		7件: Tacrolimus ,
Methotrexate (Methotrexate),
Busulfan ,
Fludarabine phosphate ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Fludarabine ,
Tacrolimus 💬 		8件: DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬 		40件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Folate transport and metabolism, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬1件: 60 💬
6Certolizumab Pegol + Methotrexate (MTX)2件: Certolizumab pegol,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Certolizumab pegol 💬 		3件: DHFR,
DHFR2,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
7Clobetasol propionate + Methotrexate3件: Clobetasol,
Clobetasol propionate,
Methotrexate (Methotrexate)		4件: Methotrexate (Methotrexate),
Clobetasol propionate ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Clobetasol 💬 		3件: DHFR,
DHFR2,
NR3C1 💬 		4件: Folate biosynthesis, Folate transport and metabolism, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬1件: 162 💬
8Combination Product: Exercise, and methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
9Combination Product: Laser, exercise, and methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
10Combination Product: Methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
11CP-690,550 + methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
12Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids3件: Azathioprine,
Cyclophosphamide,
Methotrexate (Methotrexate)		6件: Methotrexate (Methotrexate),
Azathioprine ,
Cyclophosphamide ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Azathioprine sodium ,
Cyclophosphamide 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 44 💬
13Cyclosporin, Methotrexate (GVHD prophylaxis)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 326 💬
14DMARDs (methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
15Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase3件: Cyclophosphamide,
Doxorubicin,
Methotrexate (Methotrexate)		6件: Methotrexate (Methotrexate),
Cyclophosphamide ,
Doxorubicin hydrochloride ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Doxorubicin ,
Cyclophosphamide 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 65 💬
16Early immunosuppressants (azathioprine, methotrexate)2件: Azathioprine,
Methotrexate (Methotrexate)		4件: Methotrexate (Methotrexate),
Azathioprine ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Azathioprine sodium 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 96 💬
17Etanercept + Methotrexate2件: Etanercept,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Etanercept ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		4件: DHFR,
DHFR2,
LTA,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
18Etanercept , Methotrexate2件: Etanercept,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Etanercept ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		4件: DHFR,
DHFR2,
LTA,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
19Etanercept, methotrexate and depomedrone2件: Etanercept,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Etanercept ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		4件: DHFR,
DHFR2,
LTA,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
20Etanercept, Methotrexate, Prednisolone3件: Etanercept,
Methotrexate (Methotrexate),
Prednisolone		4件: Methotrexate (Methotrexate),
Prednisolone ,
Etanercept ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		5件: DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		70件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 56 💬
21Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)3件: Azathioprine,
Methotrexate (Methotrexate),
Mycophenolate mofetil		6件: Methotrexate (Methotrexate),
Azathioprine ,
Mycophenolate mofetil ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Azathioprine sodium ,
Mycophenolate mofetil hydrochloride 💬 		4件: DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		5件: Drug metabolism - other enzymes, Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Purine metabolism 💬1件: 49 💬
22Infliximab + methotrexate (MTX)2件: Infliximab,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Infliximab 💬 		3件: DHFR,
DHFR2,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
23Infliximab plus methotrexate2件: Infliximab,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Infliximab 💬 		3件: DHFR,
DHFR2,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 107 💬
24Infliximab, methylprednisolone, methotrexate3件: Infliximab,
Methotrexate (Methotrexate),
Methylprednisolone		5件: Methotrexate (Methotrexate),
Methylprednisolone ,
Methylprednisolone acetate ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Infliximab 💬 		4件: DHFR,
DHFR2,
NR3C1,
TNF 💬 		70件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
25Inj. Methotrexate 25mg/week1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
26Intrathecal methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 13 💬
27JAK inhibitor(tofacitinib/upadacitinib) as advised by the rheumatologist as add on to 25 mg methotrexate3件: Methotrexate (Methotrexate),
Tofacitinib,
Upadacitinib		7件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tofacitinib citrate ,
Tofacitinib ,
Upadacitinib ,
Upadacitinib tartrate ,
Upadacitinib hydrate 💬 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46 💬
28Leflunomide plus Methotrexate2件: Leflunomide,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Leflunomide ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		3件: DHFR,
DHFR2,
DHODH 💬 		4件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Pyrimidine metabolism 💬1件: 107 💬
29Methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬41件: 11, 13, 14, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 223, 240, 256, 270, 271, 284, 285, 286, 326, 331 💬
30Methotrexate 'Lederle' 2,5mg tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
31Methotrexate 'Lederle' 2.5mg Tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
32Methotrexate 'Lederle' Tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
33Methotrexate (Metoject® prefilled pen)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
34Methotrexate (MTX)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬2件: 46, 55 💬
35Methotrexate (stable dose)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
36Methotrexate (tapering dose)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
37Methotrexate + Infliximab2件: Infliximab,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Infliximab 💬 		3件: DHFR,
DHFR2,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
38Methotrexate + Methylprednisolone2件: Methotrexate (Methotrexate),
Methylprednisolone		4件: Methotrexate (Methotrexate),
Methylprednisolone ,
Methylprednisolone acetate ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		3件: DHFR,
DHFR2,
NR3C1 💬 		4件: Folate biosynthesis, Folate transport and metabolism, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬1件: 46 💬
39Methotrexate + targeted therapy administration1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
40METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 96 💬
41Methotrexate - Amneal1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
42Methotrexate - DAVA1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
43Methotrexate - Delay1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
44Methotrexate - etanercept - prednisolone arm3件: Etanercept,
Methotrexate (Methotrexate),
Prednisolone		4件: Methotrexate (Methotrexate),
Prednisolone ,
Etanercept ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		5件: DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 		70件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬2件: 46, 107 💬
45Methotrexate - Immediate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
46Methotrexate 10 mg1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
47Methotrexate 10 mg tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
48Methotrexate 2.5 mg1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 44 💬
49METHOTREXATE 2.5 mg tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
50Methotrexate 2.5mg Tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
51Methotrexate 2.5mg Tablets BP1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
52Methotrexate 25 mg1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 44 💬
53Methotrexate 50mg/ml solution for injection, pre-filled syringe1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
54Methotrexate ``Lederle`` 2.5mg tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
55Methotrexate alone1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 107 💬
56Methotrexate and folic acid2件: Folic acid,
Methotrexate (Methotrexate)		4件: Folic acid ,
Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Folate sodium 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 49 💬
57Methotrexate as methotrexate disodium1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
58Methotrexate bellon1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 97 💬
59Methotrexate bellon 25mg/ml1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 97 💬
60Methotrexate capsules1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
61Methotrexate Combined With Tofacitinib2件: Methotrexate (Methotrexate),
Tofacitinib		4件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tofacitinib citrate ,
Tofacitinib 💬 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46 💬
62METHOTREXATE DISODIUM1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬5件: 46, 96, 97, 107, 271 💬
63Methotrexate Ebewe1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
64METHOTREXATE HOSPIRA 2,5 mg tablety1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
65METHOTREXATE HOSPIRA 2.5 mg tablety1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
66Methotrexate injection1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬2件: 96, 97 💬
67Methotrexate Lachema 5inj. sol1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 50 💬
68Methotrexate Lederle 2.5 mg Tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
69Methotrexate Monotherapy1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 107 💬
70Methotrexate or leflunomide + sulfasalazine + hydroxychloroquine administration4件: Hydroxychloroquine,
Leflunomide,
Methotrexate (Methotrexate),
Sulfasalazine		6件: Methotrexate (Methotrexate),
Sulfasalazine ,
Leflunomide ,
Hydroxychloroquine sulfate ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Hydroxychloroquine 💬 		3件: DHFR,
DHFR2,
DHODH 💬 		4件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Pyrimidine metabolism 💬1件: 46 💬
71Methotrexate Pfizer 2,5 mg tabletter1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
72Methotrexate ph. Eur.1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 14 💬
73Methotrexate plus ENBREL or ENBREL alone1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
74Methotrexate plus ERB-041 for 12 weeks1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
75Methotrexate plus sulfasalazine2件: Methotrexate (Methotrexate),
Sulfasalazine		3件: Methotrexate (Methotrexate),
Sulfasalazine ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
76Methotrexate pre-filled pen1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
77Methotrexate prefilled pen1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬2件: 46, 107 💬
78Methotrexate prefilled syringe1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
79METHOTREXATE SODIUM1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬2件: 46, 256 💬
80Methotrexate Sodium 2.5mg Tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
81Methotrexate Sodium Tablets 2.5 mg1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
82Methotrexate Sodium Tablets 2.5mg1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
83Methotrexate Tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬2件: 40, 46 💬
84Methotrexate tablets 2.5 mg1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
85Methotrexate treatment1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬2件: 41, 46 💬
86Methotrexate Wyeth 2,5mg1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 50 💬
87Methotrexate Wyeth 2,5mg tbl.1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 50 💬
88Methotrexate ® 2.5mg Tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
89Methotrexate(MTX)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
90Methotrexate(necessary)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
91METHOTREXATE*100CPR 2,5MG1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
92METHOTREXATE*10MG/1,33ML 4S1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
93METHOTREXATE*15MG/2ML 4SIR1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
94METHOTREXATE*2,5MG 25CPR1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
95METHOTREXATE*20MG/2,66ML 4S1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
96METHOTREXATE*25CPR 2,5MG1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬2件: 46, 107 💬
97METHOTREXATE*7,5MG/ML 4SIR.1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
98Methotrexate, Leucovorin and BMS-9861423件: BMS-986142,
Leucovorin,
Methotrexate (Methotrexate)		5件: Methotrexate (Methotrexate),
Leucovorin calcium ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Folinic acid ,
Folinic acid calcium salt pentahydrate 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
99Methotrexate-Lachema1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
100Methotrexate-Sulfasalazine-Hydroxychloroquine3件: Hydroxychloroquine,
Methotrexate (Methotrexate),
Sulfasalazine		5件: Methotrexate (Methotrexate),
Sulfasalazine ,
Hydroxychloroquine sulfate ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Hydroxychloroquine 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
101Methotrexate® 2.5 mg tablets1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
102Modified Zhiwang Decoction Combined with methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
103MP-435(dose1) + Methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
104Mycophenolate mofetil,methotrexate2件: Methotrexate (Methotrexate),
Mycophenolate mofetil		4件: Methotrexate (Methotrexate),
Mycophenolate mofetil ,
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Mycophenolate mofetil hydrochloride 💬 		4件: DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 		5件: Drug metabolism - other enzymes, Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate, Purine metabolism 💬3件: 42, 43, 45 💬
105Oral methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
106Other: Methotrexate therapy1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
107Phase 1: Methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
108Response to anakinra associated with methotrexate2件: Anakinra,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Anakinra 💬 		4件: DHFR,
DHFR2,
IL1R1,
IL1R2 💬 		18件: Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬1件: 46 💬
109Response to infliximab associated with methotrexate2件: Infliximab,
Methotrexate (Methotrexate)		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Infliximab 💬 		3件: DHFR,
DHFR2,
TNF 💬 		69件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Folate transport and metabolism, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬1件: 46 💬
110Stable weekly dose of methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
111Tab. Methotrexate 25mg/week1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
112Tacrolimus with Methotrexate2件: Methotrexate (Methotrexate),
Tacrolimus		4件: Tacrolimus ,
Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tacrolimus 💬 		7件: DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 		36件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Folate transport and metabolism, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬1件: 46 💬
113TAK-715 and methotrexate2件: Methotrexate (Methotrexate),
TAK-715		2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
114TAK-783 and methotrexate1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬
115Tasocitinib plus Methotrexate2件: Methotrexate (Methotrexate),
Tofacitinib		4件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tofacitinib citrate ,
Tofacitinib 💬 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46 💬
116To see the efficacy of Upadacitinib, Methotrexate versus Tofacitinib, Methotrexate in moderate to severe Rheumatoid arthritis3件: Methotrexate (Methotrexate),
Tofacitinib,
Upadacitinib		7件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tofacitinib citrate ,
Tofacitinib ,
Upadacitinib ,
Upadacitinib tartrate ,
Upadacitinib hydrate 💬 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46 💬
117Tocilizumab + methotrexate(MTX)2件: Methotrexate (Methotrexate),
Tocilizumab		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tocilizumab 💬 		3件: DHFR,
DHFR2,
IL6R 💬 		14件: Coronavirus disease, Cytokine-cytokine receptor interaction, Folate biosynthesis, Folate transport and metabolism, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬1件: 46 💬
118Tocilizumab plus methotrexate2件: Methotrexate (Methotrexate),
Tocilizumab		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tocilizumab 💬 		3件: DHFR,
DHFR2,
IL6R 💬 		14件: Coronavirus disease, Cytokine-cytokine receptor interaction, Folate biosynthesis, Folate transport and metabolism, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬1件: 46 💬
119Tocilizumab+Methotrexate(MTX)2件: Methotrexate (Methotrexate),
Tocilizumab		3件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tocilizumab 💬 		3件: DHFR,
DHFR2,
IL6R 💬 		14件: Coronavirus disease, Cytokine-cytokine receptor interaction, Folate biosynthesis, Folate transport and metabolism, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬1件: 46 💬
120Tofacitinib with methotrexate2件: Methotrexate (Methotrexate),
Tofacitinib		4件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tofacitinib citrate ,
Tofacitinib 💬 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46 💬
121Tofacitinib without methotrexate2件: Methotrexate (Methotrexate),
Tofacitinib		4件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE),
Tofacitinib citrate ,
Tofacitinib 💬 		6件: DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 		42件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease, Efferocytosis, Epstein-Barr virus infection, Folate biosynthesis, Folate transport and metabolism, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Hormone signaling, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬1件: 46 💬
122Treatment with systemic therapy (methotrexate)1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 162 💬
123Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level1件: Methotrexate (Methotrexate)2件: Methotrexate (Methotrexate),
Methotrexate sodium (Methotrexate sodium, METHOTREXATE) 💬 		2件: DHFR,
DHFR2 💬 		3件: Folate biosynthesis, Folate transport and metabolism, One carbon pool by folate 💬1件: 46 💬