Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Ampreloxetine 1件: Ampreloxetine1件: Ampreloxetine 💬 2件: SLC6A2,
SLC6A4 💬 		3件: Neuroactive ligand signaling, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 6, 17 💬
2 Angiotensin II 2件: Angiotensin; Angiotensin II3件: Angiotensin II ,
Angiotensin II ,
Angiotensin II acetate 💬 		2件: AGTR1,
AGTR2 💬 		17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬7件: 17, 46, 49, 66, 218, 222, 224 💬
3 Botulinum toxin type A 5件: Botulinum toxin A; Botulinum toxin type A; BTX-A; Incobotulinumtoxina; Onabotulinumtoxina2件: Botulinum toxin type A ,
Prabotulinumtoxin A 💬 		1件: SNAP25 💬 2件: Insulin secretion, Synaptic vesicle cycle 💬14件: 2, 5, 6, 7, 13, 15, 17, 47, 51, 70, 113, 149, 171, 226 💬
4 Captopril 1件: Captopril1件: Captopril 💬 1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬7件: 17, 46, 86, 96, 97, 107, 271 💬
5 Carbidopa 1件: Carbidopa1件: Carbidopa 💬 1件: DDC 💬 8件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬5件: 6, 13, 17, 140, 201 💬
6 Domperidone 1件: Domperidone2件: Domperidone ,
Domperidone maleate 💬 		1件: DRD2 💬 10件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬5件: 6, 13, 17, 51, 230 💬
7 Droxidopa 2件: Droxidopa; L-dops1件: Droxidopa 💬 9件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬 		16件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬5件: 5, 6, 17, 169, 170 💬
8 Emeramide 1件: Emeramide---2件: 5, 17 💬
9 Entacapone 2件: Entacapona; Entacapone1件: Entacapone 💬 1件: COMT 💬 3件: Dopaminergic synapse, Steroid hormone biosynthesis, Tyrosine metabolism 💬2件: 6, 17 💬
10 Epigallocatechin gallate 2件: Egcg; Epigallocatechin-3-gallate---8件: 6, 8, 13, 17, 28, 85, 206, 299 💬
11 Exenatide 1件: Exenatide1件: Exenatide 💬 1件: GLP1R 💬 4件: Hormone signaling, Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬5件: 6, 17, 78, 193, 233 💬
12 Fipamezole 1件: Fipamezole---2件: 6, 17 💬
13 Fludrocortisone 1件: Fludrocortisone2件: Fludrocortisone acetate ,
Fludrocortisone 💬 		1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬3件: 6, 17, 81 💬
14 Flumazenil 1件: Flumazenil1件: Flumazenil 💬 16件: GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRB,
GABRB,
GABRB,
GABRD,
GABRE,
GABRG,
GABRG,
GABRG,
GABRP,
GABRQ 💬 		8件: GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬5件: 6, 13, 17, 18, 206 💬
15 Fluoxetine 3件: Fluoxetine; Fluoxetine hydrochloride; Fluoxétine2件: Fluoxetine ,
Fluoxetine hydrochloride 💬 		1件: SLC6A4 💬 3件: Neuroactive ligand signaling, Serotonergic synapse, Synaptic vesicle cycle 💬3件: 13, 17, 86 💬
16 Flutemetamol 1件: Flutemetamol---5件: 5, 6, 7, 17, 127 💬
17 Flutemetamol (18F) 1件: Flutemetamol1件: Flutemetamol F 18 💬 --5件: 5, 6, 7, 17, 127 💬
18 Foralumab 1件: Foralumab---3件: 13, 17, 96 💬
19 Green tea leaf 3件: Green TEA; Green TEA leaf; TEA extract1件: Green tea leaf 💬 --5件: 6, 17, 28, 46, 96 💬
20 Hydrogen 1件: Hydrogen---7件: 5, 6, 13, 17, 97, 226, 288 💬
21 Levodopa 2件: L-dopa; Levodopa1件: Levodopa 💬 5件: DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬 		13件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬6件: 6, 17, 90, 140, 164, 201 💬
22 Lithium carbonate 1件: Lithium carbonate1件: Lithium carbonate 💬 --6件: 2, 13, 17, 18, 127, 310 💬
23 Losartan 2件: Losartan; Losartan potassium2件: Losartan potassium ,
Losartan 💬 		1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
24 Metoprolol 2件: Metoprolol; Metoprolol succinate4件: Metoprolol tartrate ,
Metoprolol succinate ,
Metoprolol ,
Metoprolol fumarate 💬 		1件: ADRB1 💬 13件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 17, 57, 58, 113, 193, 226 💬
25 Midodrine 2件: Midodrine; Midodrine hydrochloride2件: Midodrine hydrochloride ,
Midodrine 💬 		3件: ADRA1A,
ADRA1B,
ADRA1D 💬 		9件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬3件: 6, 17, 58 💬
26 Nebivolol 1件: Nebivolol2件: Nebivolol ,
Nebivolol hydrochloride 💬 		1件: ADRB1 💬 13件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 17, 85, 113, 167 💬
27 Nicotinamide 2件: Niacinamide; Nicotinamide1件: Niacinamide 💬 --20件: 2, 5, 6, 7, 8, 13, 17, 18, 21, 46, 49, 60, 63, 65, 67, 85, 97, 107, 162, 191 💬
28 Nicotinamide riboside 2件: Nicotinamide riboside; Nicotinamide riboside chloride---14件: 2, 5, 6, 7, 8, 17, 18, 21, 49, 60, 65, 85, 97, 191 💬
29 Nitrogen 1件: Nitrogen1件: Nitrogen 💬 --5件: 5, 6, 17, 211, 299 💬
30 Pittsburgh Compound B 2件: C-11 PIB; Pittsburgh compound B---3件: 6, 17, 127 💬
31 Pseudoephedrine 1件: Pseudoephedrine3件: Pseudoephedrine hydrochloride ,
Pseudoephedrine sulfate ,
Pseudoephedrine 💬 		9件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬 		16件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 17 💬
32 Rasagiline 2件: Rasagiline; Rasagiline mesylate3件: Rasagiline mesylate ,
Rasagiline ,
Rasagiline tartrate 💬 		1件: MAO 💬 13件: Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬5件: 2, 5, 6, 17, 66 💬
33 Rifampin 2件: Rifampicin; Rifampin2件: Rifampin ,
Rifampicin sodium 💬 		--10件: 6, 13, 17, 46, 84, 86, 93, 97, 299, 338 💬
34 Riluzole 1件: Riluzole1件: Riluzole 💬 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		24件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬8件: 2, 3, 5, 8, 13, 17, 203, 206 💬
35 Safinamide 2件: Safinamida; Safinamide2件: Safinamide ,
Safinamide mesylate 💬 		1件: MAO 💬 13件: Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬2件: 6, 17 💬
36 Sirolimus 2件: Rapamycin; Sirolimus1件: Sirolimus 💬 1件: MTOR 💬 49件: AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬46件: 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
37 THK-5351 1件: THK-5351---5件: 5, 6, 7, 17, 127 💬
38 Tolterodine 1件: Tolterodine2件: Tolterodine ,
Tolterodine tartrate 💬 		1件: CHRM3 💬 12件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬1件: 17 💬
39 Trimethaphan 1件: Trimethaphan---1件: 17 💬
40 Ubiquinol 1件: Ubiquinol---3件: 6, 8, 17 💬
41 Verdiperstat 1件: Verdiperstat1件: Verdiperstat 💬 1件: MPO 💬 5件: Acute myeloid leukemia, Drug metabolism - other enzymes, Neutrophil extracellular trap formation, Phagosome, Transcriptional misregulation in cancer 💬2件: 17, 127 💬
42 Water 1件: Water1件: Water 💬 --28件: 2, 5, 6, 13, 17, 19, 22, 35, 46, 51, 53, 56, 57, 63, 64, 66, 67, 72, 85, 96, 97, 206, 225, 226, 230, 274, 278, 299 💬
43 YA-101 1件: YA-101---1件: 17 💬
44 Zoledronic acid 3件: Zoledronate; Zoledronic acid; Zoledronic acid monohydrate5件: Zoledronic acid ,
Zoledronate disodium ,
Zoledronate trisodium ,
Zoledronic acid ,
Zoledronic acid hemipentahydrate 💬 		1件: FDPS 💬 3件: Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬16件: 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬