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Target Gene/Pathway Pathway / Gene

Search results

No.

KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[5] Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, Glycerolipid metabolism, Folate biosynthesis

Epalrestat 💬

[1] 10 💬

2

[3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism

Methotrexate sodium 💬

[39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
54	Adult still disease
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

3

[3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism

Methotrexate 💬

[39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
54	Adult still disease
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

4

[3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism

Methotrexate sodium 💬

[39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
54	Adult still disease
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

5

[3] One carbon pool by folate, Folate biosynthesis, Folate transport and metabolism

Methotrexate 💬

[39] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 60, 62, 65, 84, 85, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 284, 285, 286, 326, 331 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
54	Adult still disease
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

6

[2] Thiamine metabolism, Folate biosynthesis

Ilofotase alfa 💬

Recombinant human alkaline phosphatase

[1] 172 💬

7

[2] Thiamine metabolism, Folate biosynthesis

Asfotase alfa 💬

[1] 172 💬

8

[3] Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Folate biosynthesis

Pegvaliase 💬

[1] 240 💬

9

[3] Tryptophan metabolism, Folate biosynthesis, Serotonergic synapse

Telotristat 💬

[1] 97 💬

10

[3] Tryptophan metabolism, Folate biosynthesis, Serotonergic synapse

Telotristat 💬

[1] 97 💬

11

[3] Tryptophan metabolism, Folate biosynthesis, Serotonergic synapse

Rodatristat ethyl 💬

Rodatristat ethyl

[1] 86 💬

12

[3] Tryptophan metabolism, Folate biosynthesis, Serotonergic synapse

Rodatristat 💬

[1] 86 💬