Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cushing syndrome 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 46, 49, 66, 218, 222, 224 💬
2 Cushing syndrome 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 46, 49, 66, 218, 222, 224 💬
3 Cushing syndrome 💬
 [1] AGTR1 💬 Angiotensin II acetate 💬 Angiotensin II [7] 17, 46, 49, 66, 218, 222, 224 💬
4 Cushing syndrome 💬
 [1] AGTR1 💬 Azilsartan medoxomil 💬 Azilsartan medoxomil [1] 66 💬
5 Cushing syndrome 💬
 [1] AGTR1 💬 Azilsartan 💬 Azilsartan medoxomil [1] 66 💬
6 Cushing syndrome 💬
 [1] AGTR1 💬 Azilsartan kamedoxomil 💬 Azilsartan medoxomil [1] 66 💬
7 Cushing syndrome 💬
 [1] AGTR1 💬 Buloxibutid 💬 Buloxibutid [1] 85 💬
8 Cushing syndrome 💬
 [1] AGTR1 💬 Buloxibutid sodium 💬 Buloxibutid [1] 85 💬
9 Cushing syndrome 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬
10 Cushing syndrome 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
11 Cushing syndrome 💬
 [1] AGTR1 💬 Losartan potassium 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
12 Cushing syndrome 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
13 Cushing syndrome 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
14 Cushing syndrome 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬
15 Cushing syndrome 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [8] 57, 58, 66, 75, 86, 210, 222, 224 💬
16 Cushing syndrome 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
17 Cushing syndrome 💬
 [1] BRAF 💬 Dabrafenib mesylate 💬 Dabrafenib [1] 34 💬
18 Cushing syndrome 💬
 [1] BRAF 💬 Sorafenib tosylate 💬 Sorafenib [2] 34, 86 💬
19 Cushing syndrome 💬
 [1] BRAF 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
20 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine besylate 💬 Amlodipine [3] 51, 67, 298 💬
21 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine maleate 💬 Amlodipine [3] 51, 67, 298 💬
22 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [3] 51, 67, 298 💬
23 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine benzoate 💬 Amlodipine [3] 51, 67, 298 💬
24 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Bevantolol hydrochloride 💬 Bevantolol [1]  8  💬
25 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
26 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem hydrochloride 💬 Diltiazem [4] 51, 58, 86, 88 💬
27 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem malate 💬 Diltiazem [4] 51, 58, 86, 88 💬
28 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [4] 51, 58, 86, 88 💬
29 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
30 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine hydrochloride 💬 Nicardipine [2] 70, 86 💬
31 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
32 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [1] 81 💬
33 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
34 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline maleate 💬 Perhexiline [2] 58, 272 💬
35 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
36 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine hydrochloride 💬 Propiverine [1] 226 💬
37 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
38 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
39 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil hydrochloride 💬 Verapamil [4] 58, 96, 140, 167 💬
40 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
41 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Suvecaltamide 💬 Suvecaltamide [1]  6  💬
42 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Divalproex sodium 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
43 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
44 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproate sodium 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
45 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬
46 Cushing syndrome 💬
 [1] CACNA1S 💬 Pinaverium bromide 💬 Pinaverium [1] 298 💬
47 Cushing syndrome 💬
 [2] CDK4, CDK6 💬 Abemaciclib 💬 Abemaciclib [1] 34 💬
48 Cushing syndrome 💬
 [1] CRHR1 💬 Crinecerfont 💬 Crinecerfont [1] 81 💬
49 Cushing syndrome 💬
 [1] CRHR1 💬 Tildacerfont 💬 Tildacerfont [1] 81 💬
50 Cushing syndrome 💬
 [2] CRHR1, CRHR2 💬 Corticorelin 💬 Corticorelin [2] 75, 205 💬
51 Cushing syndrome 💬
 [3] CYP11A, CYP11B1, CYP17A 💬 Levoketoconazole 💬 Levoketoconazole [1] 75 💬
52 Cushing syndrome 💬
 [1] CYP11B1 💬 Metyrapone 💬 Metyrapone [1] 75 💬
53 Cushing syndrome 💬
 [1] CYP17A 💬 Abiraterone acetate 💬 Abiraterone [2] 75, 81 💬
54 Cushing syndrome 💬
 [1] EGFR 💬 Afatinib 💬 Afatinib [1] 285 💬
55 Cushing syndrome 💬
 [1] EGFR 💬 Afatinib dimaleate 💬 Afatinib [1] 285 💬
56 Cushing syndrome 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
57 Cushing syndrome 💬
 [1] EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib [2] 94, 160 💬
58 Cushing syndrome 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [2] 94, 160 💬
59 Cushing syndrome 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
60 Cushing syndrome 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
61 Cushing syndrome 💬
 [1] EGFR 💬 Lapatinib ditosylate 💬 Lapatinib [3] 34, 74, 75 💬
62 Cushing syndrome 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
63 Cushing syndrome 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
64 Cushing syndrome 💬
 [1] EGFR 💬 Neratinib maleate 💬 Neratinib [1] 34 💬
65 Cushing syndrome 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
66 Cushing syndrome 💬
 [1] KCNA4 💬 Amifampridine 💬 Amifampridine [3]  3 , 11, 12 💬
67 Cushing syndrome 💬
 [1] KCNA4 💬 Amifampridine phosphate 💬 Amifampridine [3]  3 , 11, 12 💬
68 Cushing syndrome 💬
 [1] KCNA4 💬 Dalfampridine 💬 Dalfampridine [4]  3 ,  4 , 13, 14 💬
69 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
70 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
71 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib [1] 280 💬
72 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [4] 34, 278, 279, 280 💬
73 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
74 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib [1] 34 💬
75 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
76 Cushing syndrome 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
77 Cushing syndrome 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
78 Cushing syndrome 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
79 Cushing syndrome 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
80 Cushing syndrome 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
81 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Bucladesine 💬 Bucladesine [1] 246 💬
82 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Flavoxate 💬 Flavoxate [1] 226 💬
83 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
84 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
85 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Aminophylline 💬 Aminophylline [1] 63 💬
86 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Aminophylline dihydrate 💬 Aminophylline [1] 63 💬
87 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Flavoxate hydrochloride 💬 Flavoxate [1] 226 💬
88 Cushing syndrome 💬
 [3] PDE11, PDE8, PDE8 💬 Theophylline 💬 Theophylline [2] 236, 299 💬