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Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Dopaminergic synapse 💬

[3] CACNA1B, CACNA1C, CACNA1D 💬

Cilnidipine 💬

Cilnidipine

[1] 67 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Amlodipine besylate 💬

Amlodipine

[3] 51, 67, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
298	Hereditary pancreatitis;Chronic pancreatitis;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Amlodipine maleate 💬

Amlodipine

[3] 51, 67, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
298	Hereditary pancreatitis;Chronic pancreatitis;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Amlodipine 💬

Amlodipine

[3] 51, 67, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
298	Hereditary pancreatitis;Chronic pancreatitis;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Amlodipine benzoate 💬

Amlodipine

[3] 51, 67, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
298	Hereditary pancreatitis;Chronic pancreatitis;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Bevantolol hydrochloride 💬

Bevantolol

[1] 8 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Diltiazem hydrochloride 💬

Name	Other Names
Diltiazem hydrochloride	Diltiazem hydrochloride (JP18/USP) Cardizem (TN) Cartia XT (TN) Dilacor XR (TN) Dilt-CD (TN) CARDIZEM CARDIZEM CD CARDIZEM LA DILTIAZEM HCL CD DILTIAZEM HYDROCHLORIDE IN SODIUM CHLORIDE TIAZAC CARTIA CARTIA XT DILTIAZEM HCI DILTIAZEM HCL ER DILTIAZEM HYDROCHLORIDE DILTIAZEM HYDROCHLORIDE EXTENDED RELEASE DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE MATZIM LA TIADYLT ER

Diltiazem

[4] 51, 58, 86, 88 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
58	Hypertrophic cardiomyopathy;HCM;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Diltiazem malate 💬

Diltiazem

[4] 51, 58, 86, 88 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
58	Hypertrophic cardiomyopathy;HCM;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Diltiazem 💬

Diltiazem

[4] 51, 58, 86, 88 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
58	Hypertrophic cardiomyopathy;HCM;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Isradipine 💬

Isradipine

[1] 6 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Nicardipine hydrochloride 💬

Nicardipine

[2] 70, 86 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Nicardipine 💬

Nicardipine

[2] 70, 86 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Nifedipine 💬

Nifedipine

[1] 81 💬

Disease ID	Name
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency;

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Nilvadipine 💬

Nilvadipine

[1] 90 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Perhexiline maleate 💬

Perhexiline

[2] 58, 272 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Perhexiline 💬

Perhexiline

[2] 58, 272 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Propiverine hydrochloride 💬

Propiverine

[1] 226 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Propiverine 💬

Propiverine

[1] 226 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Verapamil hydrochloride 💬

Verapamil

[4] 58, 96, 140, 167 💬

Dopaminergic synapse 💬

[2] CACNA1C, CACNA1D 💬

Verapamil 💬

Verapamil

[4] 58, 96, 140, 167 💬

Dopaminergic synapse 💬

[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4
SCN1A	sodium voltage-gated channel alpha subunit 1

Topiramate 💬

Topiramate

[5] 6 , 140, 144, 156, 193 💬

Dopaminergic synapse 💬

[1] COMT 💬

Entacapone 💬

Entacapone

[2] 6 , 17 💬

Dopaminergic synapse 💬

[1] COMT 💬

Opicapone 💬

Opicapone

[1] 6 💬

Dopaminergic synapse 💬

[1] COMT 💬

Tolcapone 💬

Tolcapone

[3] 6 , 28, 127 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
28	Systemic amyloidosis;Immunoglobulin light chain amyloidosis;Amyloid light-chain amyloidosis;AL amyloidosis;Immunoglobulin light chain amyloidosis;Immunoglobulin-related amyloidosis;Amyloid heavy-chain amyloidosis;Amyloid heavy-chain amyloidosis;AH amyloidosis;Systemic wild-type transthyretin amyloidosis;Senile systemic amyloidosis;SSA;Hereditary transthyretin amyloidosis;Familial amyloidosis;Familial amyloid polyneuropathy;FAP;Hereditary systemic amyloidosis;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Dopaminergic synapse 💬

[1] DDC 💬

Benserazide hydrochloride 💬

Benserazide

[1] 6 💬

Dopaminergic synapse 💬

[1] DDC 💬

Benserazide 💬

Benserazide

[1] 6 💬

Dopaminergic synapse 💬

[1] DDC 💬

Carbidopa 💬

Carbidopa

[5] 6 , 13, 17, 140, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
140	Dorabe syndrome;Dravet syndrome;
201	Angelman syndrome;

Dopaminergic synapse 💬

[2] DRD1, DRD2 💬

Apomorphine hydrochloride 💬

Apomorphine

[3] 5 , 6 , 7 💬

Dopaminergic synapse 💬

[2] DRD1, DRD2 💬

Apomorphine 💬

Apomorphine

[3] 5 , 6 , 7 💬

Dopaminergic synapse 💬

[2] DRD1, DRD2 💬

Flupentixol 💬

Flupentixol

[1] 97 💬

Dopaminergic synapse 💬

[2] DRD1, DRD2 💬

Flupentixol dihydrochloride 💬

Flupentixol

[1] 97 💬

Dopaminergic synapse 💬

[2] DRD1, DRD2 💬

Flupentixol decanoate 💬

Flupentixol

[1] 97 💬

Dopaminergic synapse 💬

[2] DRD1, DRD2 💬

Pergolide mesylate 💬

Pergolide

[1] 6 💬

Dopaminergic synapse 💬

[2] DRD1, DRD2 💬

Pergolide 💬

Pergolide

[1] 6 💬

Dopaminergic synapse 💬

[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬

Dexpramipexole 💬

Dexpramipexole

[1] 2 💬

Dopaminergic synapse 💬

[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬

Dopamine hydrochloride 💬

Name	Other Names
Dopamine hydrochloride	Dopamine hydrochloride (JP18/USP) Actopamin (TN) Intropin (TN) DOPAMINE HCI DOPAMINE HCI IN 5% DEXTROSE DOPAMINE HYDROCHLORIDE DOPAMINE HYDROCHLORIDE AND DEXTROSE DOPAMINE HYDROCHLORIDE IN DEXTROSE

Dopamine

[4] 6 , 7 , 74, 77 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
7	Corticobasal degeneration;Corticobasal syndrome;CBD;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;

Dopaminergic synapse 💬

[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬

Dopamine 💬

Dopamine

[4] 6 , 7 , 74, 77 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
7	Corticobasal degeneration;Corticobasal syndrome;CBD;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;

Dopaminergic synapse 💬

[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬

Foslevodopa 💬

Foslevodopa

[1] 6 💬

Dopaminergic synapse 💬

[5] DRD1, DRD2, DRD3, DRD4, DRD5 💬

Levodopa 💬

Levodopa

[6] 6 , 17, 90, 140, 164, 201 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
90	Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy;
140	Dorabe syndrome;Dravet syndrome;
164	Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome;
201	Angelman syndrome;

Dopaminergic synapse 💬

[2] DRD1, DRD5 💬

Tavapadon 💬

Tavapadon

[1] 6 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Bromocriptine mesylate 💬

Bromocriptine

[2] 6 , 74 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Bromocriptine 💬

Bromocriptine

[2] 6 , 74 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Buspirone hydrochloride 💬

Buspirone

[3] 6 , 51, 179 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Buspirone 💬

Buspirone

[3] 6 , 51, 179 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Cabergoline 💬

Cabergoline

[4] 6 , 74, 75, 77 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing syndrome;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly;

Dopaminergic synapse 💬

[1] DRD2 💬

Chlorpromazine 💬

Chlorpromazine

[1] 254 💬

Disease ID	Name
254	Porphyria;Acute intermittent porphyria;AIP;Hereditary coproporphyria;HCP;Variegate porphyria;VP;Erythropoietic protoporphyria;EPP;Porphyria cutanea tarda;PCT;Congenital erythropoietic porphyria;CEP;X-linked dominant protoporphyria;XLDP;Hepatoerythropoietic porphyria;HEP;

Dopaminergic synapse 💬

[1] DRD2 💬

Chlorpromazine hydrochloride 💬

Chlorpromazine

[1] 254 💬

Disease ID	Name
254	Porphyria;Acute intermittent porphyria;AIP;Hereditary coproporphyria;HCP;Variegate porphyria;VP;Erythropoietic protoporphyria;EPP;Porphyria cutanea tarda;PCT;Congenital erythropoietic porphyria;CEP;X-linked dominant protoporphyria;XLDP;Hepatoerythropoietic porphyria;HEP;

Dopaminergic synapse 💬

[1] DRD2 💬

Domperidone 💬

Domperidone

[5] 6 , 13, 17, 51, 230 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Dopaminergic synapse 💬

[1] DRD2 💬

Domperidone maleate 💬

Domperidone

[5] 6 , 13, 17, 51, 230 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Dopaminergic synapse 💬

[1] DRD2 💬

Haloperidol 💬

Haloperidol

[1] 8 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Haloperidol decanoate 💬

Haloperidol

[1] 8 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Haloperidol lactate 💬

Haloperidol

[1] 8 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Iloperidone 💬

Iloperidone

[1] 6 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Melperone 💬

Melperone

[1] 6 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Melperone hydrochloride 💬

Melperone

[1] 6 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Metoclopramide 💬

Metoclopramide

[1] 51 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Metoclopramide hydrochloride 💬

Metoclopramide

[1] 51 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Metoclopramide hydrochloride 💬

Metoclopramide

[1] 51 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Pimozide 💬

Pimozide

[1] 2 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Pridopidine 💬

Pridopidine

[3] 2 , 6 , 8 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Pridopidine hydrochloride 💬

Pridopidine

[3] 2 , 6 , 8 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Quetiapine fumarate 💬

Quetiapine

[1] 6 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Quetiapine 💬

Quetiapine

[1] 6 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Risperidone 💬

Risperidone

[3] 8 , 156, 187 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Rotigotine 💬

Rotigotine

[3] 6 , 67, 127 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant PKD;ADPKD;Autosomal recessive PKD;ARPKD;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Dopaminergic synapse 💬

[1] DRD2 💬

Sarizotan hydrochloride 💬

Sarizotan

[2] 6 , 156 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Terguride 💬

Terguride

[2] 51, 86 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Trifluoperazine hydrochloride 💬

Trifluoperazine

[2] 283, 284 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Trifluoperazine maleate 💬

Trifluoperazine

[2] 283, 284 💬

Dopaminergic synapse 💬

[1] DRD2 💬

Trifluoperazine 💬

Trifluoperazine

[2] 283, 284 💬

Dopaminergic synapse 💬

[2] DRD2, DRD3 💬

Aplindore fumarate 💬

Aplindore

[1] 6 💬

Dopaminergic synapse 💬

[2] DRD2, DRD3 💬

Aripiprazole 💬

Aripiprazole

[2] 6 , 206 💬

Dopaminergic synapse 💬

[2] DRD2, DRD3 💬

Pardoprunox hydrochloride 💬

Pardoprunox

[1] 6 💬

Dopaminergic synapse 💬

[2] DRD2, DRD3 💬

Pardoprunox 💬

Pardoprunox

[1] 6 💬

Dopaminergic synapse 💬

[2] DRD2, DRD3 💬

Piribedil 💬

Piribedil

[1] 6 💬

Dopaminergic synapse 💬

[3] DRD2, DRD3, DRD4 💬

Lisuride 💬

Lisuride

[2] 6 , 86 💬

Dopaminergic synapse 💬

[3] DRD2, DRD3, DRD4 💬

Olanzapine 💬

Olanzapine

[2] 2 , 8 💬

Dopaminergic synapse 💬

[3] DRD2, DRD3, DRD4 💬

Olanzapine pamoate 💬

Olanzapine

[2] 2 , 8 💬

Dopaminergic synapse 💬

[3] DRD2, DRD3, DRD4 💬

Pramipexole dihydrochloride 💬

Pramipexole

[2] 6 , 20 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
20	Adrenoleukodystrophy;ALD;Childhood cerebral ALD;CCALD;Adolescent cerebral ALD;AdoCALD;AdolCALD;Adrenomyeloneuropathy;AMN;Adult cerebral ALD;ACALD;

Dopaminergic synapse 💬

[3] DRD2, DRD3, DRD4 💬

Pramipexole 💬

Pramipexole

[2] 6 , 20 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
20	Adrenoleukodystrophy;ALD;Childhood cerebral ALD;CCALD;Adolescent cerebral ALD;AdoCALD;AdolCALD;Adrenomyeloneuropathy;AMN;Adult cerebral ALD;ACALD;

Dopaminergic synapse 💬

[3] DRD2, DRD3, DRD4 💬

Ropinirole hydrochloride 💬

Ropinirole

[3] 6 , 74, 309 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
309	Progressive myoclonus epilepsy;Unverricht-Lundborg disease;Lafora disease;Benign adult familial myoclonus epilepsy;BAFME;

Dopaminergic synapse 💬

[3] DRD2, DRD3, DRD4 💬

Ropinirole 💬

Ropinirole

[3] 6 , 74, 309 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
309	Progressive myoclonus epilepsy;Unverricht-Lundborg disease;Lafora disease;Benign adult familial myoclonus epilepsy;BAFME;

Dopaminergic synapse 💬

[1] DRD4 💬

Clozapine 💬

Clozapine

[1] 6 💬

Dopaminergic synapse 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Perampanel 💬

Perampanel

[3] 2 , 6 , 144 💬

Dopaminergic synapse 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Perampanel hydrate 💬

Perampanel

[3] 2 , 6 , 144 💬

Dopaminergic synapse 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Talampanel 💬

Talampanel

[2] 2 , 6 💬

Dopaminergic synapse 💬

[6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B

Riluzole 💬

Riluzole

[8] 2 , 3 , 5 , 8 , 13, 17, 203, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;
5	Progressive supranuclear palsy;PSP;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
203	22q11.2 deletion syndrome;
206	Fragile X syndrome;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Acamprosate calcium 💬

Acamprosate

[2] 6 , 206 💬

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Acamprosate 💬

Acamprosate

[2] 6 , 206 💬

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Amantadine hydrochloride 💬

Amantadine

[5] 2 , 6 , 8 , 13, 127 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Amantadine 💬

Amantadine

[5] 2 , 6 , 8 , 13, 127 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Dextromethorphan hydrobromide 💬

Dextromethorphan

[10] 2 , 6 , 8 , 13, 21, 46, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
85	Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
156	Rett syndrome;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Dextromethorphan 💬

Dextromethorphan

[10] 2 , 6 , 8 , 13, 21, 46, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
85	Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
156	Rett syndrome;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Esketamine 💬

Esketamine

[7] 2 , 4 , 6 , 70, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
4	Primary lateral sclerosis;PLS;
6	Parkinson disease;Disease Parkinson's;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
156	Rett syndrome;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Esketamine hydrochloride 💬

Esketamine

[7] 2 , 4 , 6 , 70, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
4	Primary lateral sclerosis;PLS;
6	Parkinson disease;Disease Parkinson's;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
156	Rett syndrome;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Ketamine hydrochloride 💬

Ketamine

[6] 6 , 13, 70, 113, 156, 215 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
70	Spinal stenosis;Extensive spinal canal stenosis;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
156	Rett syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Ketamine 💬

Ketamine

[6] 6 , 13, 70, 113, 156, 215 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
70	Spinal stenosis;Extensive spinal canal stenosis;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
156	Rett syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Latrepirdine 💬

Latrepirdine

[1] 8 💬

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Latrepirdine dihydrochloride 💬

Latrepirdine

[1] 8 💬

100

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Memantine hydrochloride 💬

Memantine

[8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
49	Systemic lupus erythematosus;SLE;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
205	Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome;
206	Fragile X syndrome;

101

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Memantine 💬

Memantine

[8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
49	Systemic lupus erythematosus;SLE;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
205	Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS;Fragile X-associated tremor;Ataxia syndrome;
206	Fragile X syndrome;

102

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Methadone hydrochloride 💬

Methadone

[1] 60 💬

103

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Methadone 💬

Methadone

[1] 60 💬

104

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Tenocyclidine 💬

Tenocyclidine

[1] 36 💬

105

Dopaminergic synapse 💬

[3] KCNJ3, KCNJ5, SCN1A 💬

Amiodarone hydrochloride 💬

Amiodarone

[1] 127 💬

106

Dopaminergic synapse 💬

[3] KCNJ3, KCNJ5, SCN1A 💬

Amiodarone 💬

Amiodarone

[1] 127 💬

107

Dopaminergic synapse 💬

[1] MAO 💬

Moclobemide 💬

Moclobemide

[1] 6 💬

108

Dopaminergic synapse 💬

[1] MAO 💬

Rasagiline mesylate 💬

Rasagiline

[5] 2 , 5 , 6 , 17, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

109

Dopaminergic synapse 💬

[1] MAO 💬

Rasagiline 💬

Rasagiline

[5] 2 , 5 , 6 , 17, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

110

Dopaminergic synapse 💬

[1] MAO 💬

Rasagiline tartrate 💬

Rasagiline

[5] 2 , 5 , 6 , 17, 66 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

111

Dopaminergic synapse 💬

[1] MAO 💬

Safinamide 💬

Safinamide

[2] 6 , 17 💬

112

Dopaminergic synapse 💬

[1] MAO 💬

Safinamide mesylate 💬

Safinamide

[2] 6 , 17 💬

113

Dopaminergic synapse 💬

[1] MAO 💬

Selegiline hydrochloride 💬

Selegiline

[1] 6 💬

114

Dopaminergic synapse 💬

[1] MAO 💬

Selegiline 💬

Selegiline

[1] 6 💬

115

Dopaminergic synapse 💬

[2] MAO, MAO 💬

Iproniazid 💬

Iproniazid

[1] 6 💬

116

Dopaminergic synapse 💬

[2] MAO, MAO 💬

Iproniazid phosphate 💬

Iproniazid

[1] 6 💬

117

Dopaminergic synapse 💬

[3] MAO, MAO, SLC6A3 💬

Phentermine 💬

Phentermine

[1] 97 💬

118

Dopaminergic synapse 💬

[3] MAO, MAO, SLC6A3 💬

Phentermine hydrochloride 💬

Phentermine

[1] 97 💬

119

Dopaminergic synapse 💬

[4] P38, P38, P38, P38 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

Disease ID

Name

113

Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;

222

Primary nephrotic syndrome;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Membranoproliferative glomerulonephritis;MPGN;

120

Dopaminergic synapse 💬

[4] P38, P38, P38, P38 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

121

Dopaminergic synapse 💬

[3] PPP3C, PPP3C, PPP3C 💬

Cyclosporine 💬

Name	Other Names
Cyclosporine	Cyclosporine (USP) Ciclosporin (JP18) Gengraf (TN) Neoral (TN) Restasis (TN) Sandimmune (TN) CEQUA NEORAL RESTASIS RESTASIS MULTIDOSE SANDIMMUNE VERKAZIA VEVYE CYCLOSPORINE CYCLOSPORINE, MODFIED GENGRAF

Cyclosporine

[42] 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬

Disease ID	Name
11	Myasthenia gravis;MG;
19	Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis;
20	Adrenoleukodystrophy;ALD;Childhood cerebral ALD;CCALD;Adolescent cerebral ALD;AdoCALD;AdolCALD;Adrenomyeloneuropathy;AMN;Adult cerebral ALD;ACALD;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM;
28	Systemic amyloidosis;Immunoglobulin light chain amyloidosis;Amyloid light-chain amyloidosis;AL amyloidosis;Immunoglobulin light chain amyloidosis;Immunoglobulin-related amyloidosis;Amyloid heavy-chain amyloidosis;Amyloid heavy-chain amyloidosis;AH amyloidosis;Systemic wild-type transthyretin amyloidosis;Senile systemic amyloidosis;SSA;Hereditary transthyretin amyloidosis;Familial amyloidosis;Familial amyloid polyneuropathy;FAP;Hereditary systemic amyloidosis;
36	Epidermolysis bullosa;Kindler syndrome;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
54	Adult still disease;Adult-onset Still's disease;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
58	Hypertrophic cardiomyopathy;HCM;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;Cold agglutinin disease;CAD;Paroxysmal cold hemoglobinuria;Evans syndrome;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;Immune thrombocytopenic purpura;
64	Thrombotic thrombocytopenic purpura;TTP;Upshaw-Schulman syndrome;USS;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
162	Pemphigoid;
164	Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome;
222	Primary nephrotic syndrome;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Membranoproliferative glomerulonephritis;MPGN;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;Contiguous ABCD1/DXS1357E deletion syndrome;CADDS;Peroxisome biogenesis disorder;PBD;PEX gene disorder;Zellweger syndrome;Neonatal adrenoleukodystrophy;Infantile Refsum disease;Rhizomelic chondrodysplasia punctata type 1;RCDP type 1;RCDP1;Peroxisomal beta-oxidation enzyme deficiency;Acyl-CoA oxidase deficiency;AOX deficiency;D-Bifunctional protein deficiency;DBP deficiency;Sterol carrier protein X deficiency;SCPx deficiency;2-methylacyl-CoA racemase deficiency;Alpha-methylacyl-CoA racemase deficiency;AMACR deficiency;Plasmalogen biosynthesis enzyme deficiency;Rhizomelic chondrodysplasia punctata type 2;RCDP type 2;RCDP2;Rhizomelic chondrodysplasia punctata type 3;RCDP type 3;RCDP3;Refsum disease;Primary hyperoxaluria type 1;PH1;Primary hyperoxaluria;Acatalasemia;Acatalasia;Takahara disease;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
274	Osteogenesis Imperfecta;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
302	Leber hereditary optic neuropathy;LHON;Leber disease;
326	Osteopetrosis;Neonatal/infantile osteopetrosis;Intermediate osteopetrosis;Delayed-onset osteopetrosis;

122

Dopaminergic synapse 💬

[3] PPP3C, PPP3C, PPP3C 💬

Pimecrolimus 💬

Pimecrolimus

[1] 160 💬

Disease ID

Name

160

Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS;

123

Dopaminergic synapse 💬

[3] PPP3C, PPP3C, PPP3C 💬

Voclosporin 💬

Voclosporin

[2] 49, 222 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
222	Primary nephrotic syndrome;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Membranoproliferative glomerulonephritis;MPGN;

124

Dopaminergic synapse 💬

[3] PPP3C, PPP3C, PPP3C 💬

Tacrolimus 💬

Tacrolimus

[33] 2 , 6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
36	Epidermolysis bullosa;Kindler syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;Cold agglutinin disease;CAD;Paroxysmal cold hemoglobinuria;Evans syndrome;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
95	Autoimmune hepatitis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
151	Rasmussen encephalitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
164	Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome;
222	Primary nephrotic syndrome;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Membranoproliferative glomerulonephritis;MPGN;
224	Purpura nephritis;Henoch-Schönlein purpura nephritis;HSPN;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;Contiguous ABCD1/DXS1357E deletion syndrome;CADDS;Peroxisome biogenesis disorder;PBD;PEX gene disorder;Zellweger syndrome;Neonatal adrenoleukodystrophy;Infantile Refsum disease;Rhizomelic chondrodysplasia punctata type 1;RCDP type 1;RCDP1;Peroxisomal beta-oxidation enzyme deficiency;Acyl-CoA oxidase deficiency;AOX deficiency;D-Bifunctional protein deficiency;DBP deficiency;Sterol carrier protein X deficiency;SCPx deficiency;2-methylacyl-CoA racemase deficiency;Alpha-methylacyl-CoA racemase deficiency;AMACR deficiency;Plasmalogen biosynthesis enzyme deficiency;Rhizomelic chondrodysplasia punctata type 2;RCDP type 2;RCDP2;Rhizomelic chondrodysplasia punctata type 3;RCDP type 3;RCDP3;Refsum disease;Primary hyperoxaluria type 1;PH1;Primary hyperoxaluria;Acatalasemia;Acatalasia;Takahara disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
299	Cystic fibrosis;CF;

125

Dopaminergic synapse 💬

[3] PPP3C, PPP3C, PPP3C 💬

Tacrolimus 💬

Tacrolimus

[33] 2 , 6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
36	Epidermolysis bullosa;Kindler syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;Cold agglutinin disease;CAD;Paroxysmal cold hemoglobinuria;Evans syndrome;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
95	Autoimmune hepatitis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
151	Rasmussen encephalitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;TSC;
164	Oculocutaneous albinism;Hermansky-Pudlak syndrome;HPS;Chediak-Higashi syndrome;Chédiak-Higashi syndrome;CHS;Griscelli syndrome;
222	Primary nephrotic syndrome;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Membranoproliferative glomerulonephritis;MPGN;
224	Purpura nephritis;Henoch-Schönlein purpura nephritis;HSPN;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;HHT;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;Contiguous ABCD1/DXS1357E deletion syndrome;CADDS;Peroxisome biogenesis disorder;PBD;PEX gene disorder;Zellweger syndrome;Neonatal adrenoleukodystrophy;Infantile Refsum disease;Rhizomelic chondrodysplasia punctata type 1;RCDP type 1;RCDP1;Peroxisomal beta-oxidation enzyme deficiency;Acyl-CoA oxidase deficiency;AOX deficiency;D-Bifunctional protein deficiency;DBP deficiency;Sterol carrier protein X deficiency;SCPx deficiency;2-methylacyl-CoA racemase deficiency;Alpha-methylacyl-CoA racemase deficiency;AMACR deficiency;Plasmalogen biosynthesis enzyme deficiency;Rhizomelic chondrodysplasia punctata type 2;RCDP type 2;RCDP2;Rhizomelic chondrodysplasia punctata type 3;RCDP type 3;RCDP3;Refsum disease;Primary hyperoxaluria type 1;PH1;Primary hyperoxaluria;Acatalasemia;Acatalasia;Takahara disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
286	Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia;
299	Cystic fibrosis;CF;

126

Dopaminergic synapse 💬

[1] PRKCB 💬

Enzastaurin hydrochloride 💬

Enzastaurin

[1] 168 💬

Disease ID

Name

168

Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS;

127

Dopaminergic synapse 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Disease ID

Name

168

128

Dopaminergic synapse 💬

[1] SCN1A 💬

Bupivacaine hydrochloride 💬

Name	Other Names
Bupivacaine hydrochloride	Bupivacaine hydrochloride (USP) Bupivacaine hydrochloride hydrate (JP18) Marcaine (TN) BUPIVACAINE HCL MARCAINE MARCAINE SPINAL SENSORCAINE BUPIVACAINE BUPIVACAINE HCI BUPIVACAINE HYDROCHLORIDE BUPIVACAINE HYDROCHLORIDE INJECTION, SOLUTION BUPIVACAINE HYDROCHLORIDE WITH DEXTROSE BUPIVICAINE HYDROCHLORIDE SENSORCAINE MPF

Bupivacaine

[6] 46, 53, 70, 96, 168, 226 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
168	Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;

129

Dopaminergic synapse 💬

[1] SCN1A 💬

Bupivacaine 💬

Bupivacaine

[6] 46, 53, 70, 96, 168, 226 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
168	Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;

130

Dopaminergic synapse 💬

[1] SCN1A 💬

Carbamazepine 💬

Carbamazepine

[3] 6 , 13, 231 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
231	Alpha-1-antitrypsin deficiency;AATD;

131

Dopaminergic synapse 💬

[1] SCN1A 💬

Eleclazine 💬

Eleclazine

[1] 58 💬

132

Dopaminergic synapse 💬

[1] SCN1A 💬

Flecainide acetate 💬

Flecainide

[2] 6 , 115 💬

133

Dopaminergic synapse 💬

[1] SCN1A 💬

Flecainide 💬

Flecainide

[2] 6 , 115 💬

134

Dopaminergic synapse 💬

[1] SCN1A 💬

Lamotrigine 💬

Lamotrigine

[6] 13, 34, 38, 113, 114, 144 💬

Disease ID	Name
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
114	Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Autosomal-dominant myotonia congenita;Becker disease;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia;
144	Lennox-Gastaut syndrome;

135

Dopaminergic synapse 💬

[1] SCN1A 💬

Levobupivacaine hydrochloride 💬

Levobupivacaine

[1] 46 💬

136

Dopaminergic synapse 💬

[1] SCN1A 💬

Levobupivacaine 💬

Levobupivacaine

[1] 46 💬

137

Dopaminergic synapse 💬

[1] SCN1A 💬

Lidocaine 💬

Name	Other Names
Lidocaine	Lidocaine (JP18/USP/INN) Dentipatch (TN) Xylocaine (TN) LIDODERM ZTLIDO LIDOCAINE LIDOCAINE 5% LIDOCAINE 5% PATCH LIDOCAINE PATCH LIDOCAN LIDOCAN III LIDOCAN IV LIDOCAN V LIDOCAN VI LIDOCAN VII TRIDACAINE II TRIDACAINE III TRIDACAINE XL

Lidocaine

[14] 6 , 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
168	Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
231	Alpha-1-antitrypsin deficiency;AATD;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;Glycogen storage disease type 0;GSD0;Glycogen synthase deficiency;Glycogen storage disease type II;GSDII;Pompe disease;Alpha-1,4-glucosidase acid deficiency;Glycogen storage disease type III;GSDIII;Cori disease;Forbes disease;Glycogen debranching enzyme deficiency;Glycogen storage disease type IV;GSDIV;Andersen disease;Glycogen-branching enzyme deficiency;GBED;Glycogen storage disease type V;GSDV;McArdle disease;Muscle phosphorylase deficiency;Muscular phosphorylase deficiency;Glycogen storage disease type VII;GSDVII;Tarui disease;Phosphofructokinase deficiency;PFK deficiency;Glycogen storage disease type IXd;GSDIXd;Phosphorylase kinase deficiency;Phosphoglycerate kinase deficiency;PGK deficiency;Glycogen storage disease type X;GSDX;Phosphoglycerate mutase deficiency;Glycogen storage diseass type XI;GSDXI;Kanno disease;Lactate dehydrogenase deficiency;Glycogen storage diseass type XII;GSDXII;Aldolase A deficiency;Glycogen storage diseass type XIII;GSDXIII;Beta-enolase deficiency;Glycogen storage diseass type XIV;GSDXIV;Phosphoglucomutase deficiency;Glycogen storage diseass type XV;GSDXV;Glycogenin 1 deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;

138

Dopaminergic synapse 💬

[1] SCN1A 💬

Lidocaine hydrochloride 💬

Name	Other Names
Lidocaine hydrochloride	Lidocaine hydrochloride (JAN/USP) Dalcaine (TN) Xylocaine (TN) AKTEN LIDOCAINE LIDOCAINE HCI LIDOCAINE HCI AND DEXTROSE LIDOCAINE HYDROCHLORIDE AND DEXTROSE XYLOCAIN XYLOCAINE XYLOCAINE MPF XYLOCAINE- MPF 0.5% LIDOCAINE HCL GLYDO GLYDO- LIDOCAINE HYDROCHLORIDE JELLY LIDOCAINE HCL LIDOCAINE HYDROCHLORIDE LIDOCAINE VISCOUS NA

Lidocaine

[14] 6 , 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
168	Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
231	Alpha-1-antitrypsin deficiency;AATD;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;Glycogen storage disease type 0;GSD0;Glycogen synthase deficiency;Glycogen storage disease type II;GSDII;Pompe disease;Alpha-1,4-glucosidase acid deficiency;Glycogen storage disease type III;GSDIII;Cori disease;Forbes disease;Glycogen debranching enzyme deficiency;Glycogen storage disease type IV;GSDIV;Andersen disease;Glycogen-branching enzyme deficiency;GBED;Glycogen storage disease type V;GSDV;McArdle disease;Muscle phosphorylase deficiency;Muscular phosphorylase deficiency;Glycogen storage disease type VII;GSDVII;Tarui disease;Phosphofructokinase deficiency;PFK deficiency;Glycogen storage disease type IXd;GSDIXd;Phosphorylase kinase deficiency;Phosphoglycerate kinase deficiency;PGK deficiency;Glycogen storage disease type X;GSDX;Phosphoglycerate mutase deficiency;Glycogen storage diseass type XI;GSDXI;Kanno disease;Lactate dehydrogenase deficiency;Glycogen storage diseass type XII;GSDXII;Aldolase A deficiency;Glycogen storage diseass type XIII;GSDXIII;Beta-enolase deficiency;Glycogen storage diseass type XIV;GSDXIV;Phosphoglucomutase deficiency;Glycogen storage diseass type XV;GSDXV;Glycogenin 1 deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;

139

Dopaminergic synapse 💬

[1] SCN1A 💬

Lidocaine hydrochloride monohydrate 💬

Name	Other Names
Lidocaine hydrochloride monohydrate	Lidocaine hydrochloride monohydrate Lidocaine (TN) Zingo (TN) ZINGO 1% LIDOCAINE HCI 2% LIDOCAINE HCI LIDOCAINE HCI LIDOCAINE HCL LIDOCAINE HYDROCHLORIDE LIDOCAINE VISCOUS NA

Lidocaine

[14] 6 , 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
168	Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
231	Alpha-1-antitrypsin deficiency;AATD;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;Glycogen storage disease type 0;GSD0;Glycogen synthase deficiency;Glycogen storage disease type II;GSDII;Pompe disease;Alpha-1,4-glucosidase acid deficiency;Glycogen storage disease type III;GSDIII;Cori disease;Forbes disease;Glycogen debranching enzyme deficiency;Glycogen storage disease type IV;GSDIV;Andersen disease;Glycogen-branching enzyme deficiency;GBED;Glycogen storage disease type V;GSDV;McArdle disease;Muscle phosphorylase deficiency;Muscular phosphorylase deficiency;Glycogen storage disease type VII;GSDVII;Tarui disease;Phosphofructokinase deficiency;PFK deficiency;Glycogen storage disease type IXd;GSDIXd;Phosphorylase kinase deficiency;Phosphoglycerate kinase deficiency;PGK deficiency;Glycogen storage disease type X;GSDX;Phosphoglycerate mutase deficiency;Glycogen storage diseass type XI;GSDXI;Kanno disease;Lactate dehydrogenase deficiency;Glycogen storage diseass type XII;GSDXII;Aldolase A deficiency;Glycogen storage diseass type XIII;GSDXIII;Beta-enolase deficiency;Glycogen storage diseass type XIV;GSDXIV;Phosphoglucomutase deficiency;Glycogen storage diseass type XV;GSDXV;Glycogenin 1 deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;

140

Dopaminergic synapse 💬

[1] SCN1A 💬

Mexiletine hydrochloride 💬

Mexiletine

[5] 1 , 2 , 10, 113, 114 💬

Disease ID	Name
1	Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy-Alter-Sung syndrome;
2	Amyotrophic lateral sclerosis;ALS;
10	Charcot-Marie-Tooth disease;CMT;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
114	Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Autosomal-dominant myotonia congenita;Becker disease;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia;

141

Dopaminergic synapse 💬

[1] SCN1A 💬

Mexiletine 💬

Mexiletine

[5] 1 , 2 , 10, 113, 114 💬

Disease ID	Name
1	Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy-Alter-Sung syndrome;
2	Amyotrophic lateral sclerosis;ALS;
10	Charcot-Marie-Tooth disease;CMT;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
114	Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;Myotonia congenita;Thomsen disease;Autosomal-dominant myotonia congenita;Becker disease;Autosomal-recessive myotonia congenita;Paramyotonia congenita;Sodium channel myotonia;

142

Dopaminergic synapse 💬

[1] SCN1A 💬

Oxcarbazepine 💬

Oxcarbazepine

[1] 13 💬

143

Dopaminergic synapse 💬

[1] SCN1A 💬

Benoxinate hydrochloride 💬

Oxybuprocaine

[1] 6 💬

144

Dopaminergic synapse 💬

[1] SCN1A 💬

Oxybuprocaine 💬

Oxybuprocaine

[1] 6 💬

145

Dopaminergic synapse 💬

[1] SCN1A 💬

Phenytoin 💬

Phenytoin

[1] 13 💬

146

Dopaminergic synapse 💬

[1] SCN1A 💬

Phenytoin sodium 💬

Phenytoin

[1] 13 💬

147

Dopaminergic synapse 💬

[1] SCN1A 💬

Quinidine gluconate 💬

Quinidine

[2] 8 , 13 💬

148

Dopaminergic synapse 💬

[1] SCN1A 💬

Quinidine polygalacturonate 💬

Quinidine

[2] 8 , 13 💬

149

Dopaminergic synapse 💬

[1] SCN1A 💬

Quinidine sulfate 💬

Quinidine

[2] 8 , 13 💬

150

Dopaminergic synapse 💬

[1] SCN1A 💬

Quinidine 💬

Quinidine

[2] 8 , 13 💬

151

Dopaminergic synapse 💬

[1] SCN1A 💬

Ropivacaine hydrochloride 💬

Ropivacaine

[5] 22, 36, 46, 70, 97 💬

Disease ID	Name
22	Moyamoya disease;Occlusive disease in circle of Willis;
36	Epidermolysis bullosa;Kindler syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

152

Dopaminergic synapse 💬

[1] SCN1A 💬

Ropivacaine 💬

Ropivacaine

[5] 22, 36, 46, 70, 97 💬

Disease ID	Name
22	Moyamoya disease;Occlusive disease in circle of Willis;
36	Epidermolysis bullosa;Kindler syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
70	Spinal stenosis;Extensive spinal canal stenosis;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;

153

Dopaminergic synapse 💬

[1] SCN1A 💬

Rufinamide 💬

Rufinamide

[1] 144 💬

154

Dopaminergic synapse 💬

[1] SCN1A 💬

Zonisamide 💬

Zonisamide

[1] 6 💬

155

Dopaminergic synapse 💬

[1] SLC18A1_2 💬

Deutetrabenazine 💬

Deutetrabenazine

[1] 8 💬

156

Dopaminergic synapse 💬

[1] SLC18A1_2 💬

Tetrabenazine 💬

Tetrabenazine

[1] 8 💬

157

Dopaminergic synapse 💬

[1] SLC18A1_2 💬

Valbenazine 💬

Valbenazine

[1] 8 💬

158

Dopaminergic synapse 💬

[1] SLC18A1_2 💬

Valbenazine tosylate 💬

Valbenazine

[1] 8 💬

159

Dopaminergic synapse 💬

[2] SLC18A1_2, SLC6A3 💬

Midomafetamine 💬

Midomafetamine

[1] 72 💬

Disease ID	Name
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH;

160

Dopaminergic synapse 💬

[2] SLC18A1_2, SLC6A3 💬

Midomafetamine hydrochloride 💬

Midomafetamine

[1] 72 💬

Disease ID	Name
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;Central diabetes insipidus;Syndrome of inappropriate secretion of ADH;SIADH;

161

Dopaminergic synapse 💬

[1] SLC6A3 💬

Armodafinil 💬

Armodafinil

[3] 6 , 13, 84 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
84	Sarcoidosis;

162

Dopaminergic synapse 💬

[1] SLC6A3 💬

Bupropion hydrochloride 💬

Name	Other Names
Bupropion hydrochloride	Bupropion hydrochloride (JAN/USP) Wellbutrin (TN) Zyban (TN) FORFIVO WELLBUTRIN BUPROPION BUPROPION HCL BUPROPION HCL ER BUPROPION HYDROCHLORIDE BUPROPION HYDROCHLORIDE SR

Bupropion

[6] 8 , 18, 21, 96, 97, 171 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
18	Spinocerebellar degeneration;SCD;:Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysial atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Neu:Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
171	Wilson disease;WD;

163

Dopaminergic synapse 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[6] 8 , 18, 21, 96, 97, 171 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
18	Spinocerebellar degeneration;SCD;:Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysial atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Neu:Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
171	Wilson disease;WD;

164

Dopaminergic synapse 💬

[1] SLC6A3 💬

Bupropion hydrobromide 💬

Bupropion

[6] 8 , 18, 21, 96, 97, 171 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
18	Spinocerebellar degeneration;SCD;:Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysial atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Neu:Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
21	Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
171	Wilson disease;WD;

165

Dopaminergic synapse 💬

[1] SLC6A3 💬

Ioflupane I 123 💬

Ioflupane I-123

[1] 6 💬

166

Dopaminergic synapse 💬

[1] SLC6A3 💬

Lisdexamfetamine dimesylate 💬

Lisdexamfetamine

[1] 13 💬

167

Dopaminergic synapse 💬

[1] SLC6A3 💬

Lisdexamfetamine 💬

Lisdexamfetamine

[1] 13 💬

168

Dopaminergic synapse 💬

[1] SLC6A3 💬

Methylphenidate hydrochloride 💬

Name	Other Names
Methylphenidate hydrochloride	Methylphenidate hydrochloride (JAN/USP) Concerta (TN) Metadate (TN) Quillivant xr (TN) Ritalin (TN) APTENSIO XR CONCERTA COTEMPLA XR-ODT JORNAY PM METADATE CD METHYLIN METHYLPHENIDATE HYDROCHLORIDE QUILLICHEW ER QUILLIVANT RELEXXII RITALIN METHYLPHENIDATE METHYLPHENIDATE HCL METHYLPHENIDATE HYDROCHLORIDE CD METHYLPHENIDATE HYDROCHLORIDE EXTENDED RELEASE

Methylphenidate

[7] 6 , 13, 34, 84, 113, 179, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
84	Sarcoidosis;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
179	Williams syndrome;
206	Fragile X syndrome;

169

Dopaminergic synapse 💬

[1] SLC6A3 💬

Methylphenidate 💬

Methylphenidate

[7] 6 , 13, 34, 84, 113, 179, 206 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
84	Sarcoidosis;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
179	Williams syndrome;
206	Fragile X syndrome;

170

Dopaminergic synapse 💬

[1] SLC6A3 💬

Solriamfetol 💬

Solriamfetol

[1] 13 💬

171

Dopaminergic synapse 💬

[1] SLC6A3 💬

Solriamfetol hydrochloride 💬

Solriamfetol

[1] 13 💬