Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 MAPK signaling pathway 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
2 MAPK signaling pathway 💬
 [1] BRAF 💬 Dabrafenib mesylate 💬 Dabrafenib [1] 34 💬
3 MAPK signaling pathway 💬
 [8] BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET 💬 Sorafenib tosylate 💬 Sorafenib [2] 34, 86 💬
4 MAPK signaling pathway 💬
 [8] BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
5 MAPK signaling pathway 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
6 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine besylate 💬 Amlodipine [3] 51, 67, 298 💬
7 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine maleate 💬 Amlodipine [3] 51, 67, 298 💬
8 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [3] 51, 67, 298 💬
9 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine benzoate 💬 Amlodipine [3] 51, 67, 298 💬
10 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Bevantolol hydrochloride 💬 Bevantolol [1]  8  💬
11 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem hydrochloride 💬 Diltiazem [4] 51, 58, 86, 88 💬
12 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem malate 💬 Diltiazem [4] 51, 58, 86, 88 💬
13 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [4] 51, 58, 86, 88 💬
14 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
15 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine hydrochloride 💬 Nicardipine [2] 70, 86 💬
16 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
17 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [1] 81 💬
18 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
19 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline maleate 💬 Perhexiline [2] 58, 272 💬
20 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
21 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine hydrochloride 💬 Propiverine [1] 226 💬
22 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
23 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
24 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil hydrochloride 💬 Verapamil [4] 58, 96, 140, 167 💬
25 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
26 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Suvecaltamide 💬 Suvecaltamide [1]  6  💬
27 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Divalproex sodium 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
28 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
29 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproate sodium 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
30 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬
31 MAPK signaling pathway 💬
 [1] CACNA1S 💬 Pinaverium bromide 💬 Pinaverium [1] 298 💬
32 MAPK signaling pathway 💬
 [2] CACNA2D1, CACNA2D2 💬 Mirogabalin 💬 Mirogabalin [1] 70 💬
33 MAPK signaling pathway 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Gabapentin 💬 Gabapentin [5]  6 , 13, 19, 70, 298 💬
34 MAPK signaling pathway 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Pregabalin 💬 Pregabalin [5] 13, 36, 46, 70, 298 💬
35 MAPK signaling pathway 💬
 [1] CSF1R 💬 Axatilimab 💬 Axatilimab [1] 85 💬
36 MAPK signaling pathway 💬
 [9] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB, RET 💬 Sunitinib malate 💬 Sunitinib [2] 28, 34 💬
37 MAPK signaling pathway 💬
 [9] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB, RET 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
38 MAPK signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
39 MAPK signaling pathway 💬
 [1] EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib [2] 94, 160 💬
40 MAPK signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [2] 94, 160 💬
41 MAPK signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
42 MAPK signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
43 MAPK signaling pathway 💬
 [2] EGFR, ERBB2 💬 Lapatinib ditosylate 💬 Lapatinib [3] 34, 74, 75 💬
44 MAPK signaling pathway 💬
 [2] EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
45 MAPK signaling pathway 💬
 [3] EGFR, ERBB2, ERBB4 💬 Afatinib 💬 Afatinib [1] 285 💬
46 MAPK signaling pathway 💬
 [3] EGFR, ERBB2, ERBB4 💬 Afatinib dimaleate 💬 Afatinib [1] 285 💬
47 MAPK signaling pathway 💬
 [3] EGFR, ERBB2, ERBB4 💬 Neratinib 💬 Neratinib [1] 34 💬
48 MAPK signaling pathway 💬
 [3] EGFR, ERBB2, ERBB4 💬 Neratinib maleate 💬 Neratinib [1] 34 💬
49 MAPK signaling pathway 💬
 [4] EGFR, ERBB2, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
50 MAPK signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
51 MAPK signaling pathway 💬
 [3] EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
52 MAPK signaling pathway 💬
 [1] FGF19 💬 Aldafermin 💬 Aldafermin [1] 94 💬
53 MAPK signaling pathway 💬
 [1] FGF23 💬 Burosumab 💬 Burosumab [1] 238 💬
54 MAPK signaling pathway 💬
 [3] FGFR1, FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib [1] 276 💬
55 MAPK signaling pathway 💬
 [3] FGFR1, FGFR2, FGFR3 💬 Infigratinib phosphate 💬 Infigratinib [1] 276 💬
56 MAPK signaling pathway 💬
 [10] FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Catequentinib 💬 Anlotinib [1] 85 💬
57 MAPK signaling pathway 💬
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
58 MAPK signaling pathway 💬
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
59 MAPK signaling pathway 💬
 [1] FGFR2 💬 Palifermin 💬 Palifermin [6] 13, 36, 38, 39, 65, 96 💬
60 MAPK signaling pathway 💬
 [1] FGFR3 💬 Recifercept 💬 Recifercept [1] 276 💬
61 MAPK signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
62 MAPK signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
63 MAPK signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Cediranib maleate 💬 Cediranib [1] 34 💬
64 MAPK signaling pathway 💬
 [6] FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Pazopanib hydrochloride 💬 Pazopanib [1] 227 💬
65 MAPK signaling pathway 💬
 [1] FLT3 💬 Pacritinib 💬 Pacritinib [1] 331 💬
66 MAPK signaling pathway 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
67 MAPK signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [4] 96, 168, 265, 299 💬
68 MAPK signaling pathway 💬
 [1] IGF1R 💬 Mecasermin rinfabate 💬 Mecasermin [4] 96, 168, 265, 299 💬
69 MAPK signaling pathway 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬
70 MAPK signaling pathway 💬
 [2] IL1A, IL1B 💬 Lutikizumab 💬 Lutikizumab [3] 46, 96, 97 💬
71 MAPK signaling pathway 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [5] 51, 84, 106, 107, 266 💬
72 MAPK signaling pathway 💬
 [3] IL1A, IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
73 MAPK signaling pathway 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [11] 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
74 MAPK signaling pathway 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
75 MAPK signaling pathway 💬
 [1] IL1R1 💬 Anakinra 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
76 MAPK signaling pathway 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
77 MAPK signaling pathway 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
78 MAPK signaling pathway 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [1] 156 💬
79 MAPK signaling pathway 💬
 [1] INSR 💬 Insulin lispro 💬 Insulin lispro [1] 53 💬
80 MAPK signaling pathway 💬
 [2] KDR, MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
81 MAPK signaling pathway 💬
 [2] KDR, MET 💬 Cabozantinib s-malate 💬 Cabozantinib [1] 34 💬
82 MAPK signaling pathway 💬
 [1] KIT 💬 Barzolvolimab 💬 Barzolvolimab [1] 98 💬
83 MAPK signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
84 MAPK signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib mesylate 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
85 MAPK signaling pathway 💬
 [2] KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
86 MAPK signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
87 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
88 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
89 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib [1] 280 💬
90 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [4] 34, 278, 279, 280 💬
91 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
92 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib [1] 34 💬
93 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
94 MAPK signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
95 MAPK signaling pathway 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
96 MAPK signaling pathway 💬
 [1] MAPKAPK2 💬 Zunsemetinib 💬 Zunsemetinib [1] 46 💬
97 MAPK signaling pathway 💬
 [1] MAPT 💬 Bepranemab 💬 Bepranemab [1]  5  💬
98 MAPK signaling pathway 💬
 [1] MAPT 💬 Flortaucipir F 18 💬 Flortaucipir [3]  5 ,  7 , 127 💬
99 MAPK signaling pathway 💬
 [1] MAPT 💬 Gosuranemab 💬 Gosuranemab [1]  5  💬
100 MAPK signaling pathway 💬
 [1] MAPT 💬 Hydromethylthionine mesylate 💬 Hydromethylthionine mesylate [1] 127 💬
101 MAPK signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [6] 46, 49, 51, 53, 271, 300 💬
102 MAPK signaling pathway 💬
 [1] NGFB 💬 Tanezumab 💬 Tanezumab [2] 226, 298 💬
103 MAPK signaling pathway 💬
 [1] NGFR 💬 Cenegermin 💬 Cenegermin [1] 53 💬
104 MAPK signaling pathway 💬
 [4] P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
105 MAPK signaling pathway 💬
 [4] P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
106 MAPK signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 Seralutinib 💬 Seralutinib [1] 86 💬
107 MAPK signaling pathway 💬
 [3] PGF, VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
108 MAPK signaling pathway 💬
 [5] PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine [42] 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
109 MAPK signaling pathway 💬
 [5] PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus [33]  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
110 MAPK signaling pathway 💬
 [5] PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬
111 MAPK signaling pathway 💬
 [5] PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus [33]  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
112 MAPK signaling pathway 💬
 [5] PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬
113 MAPK signaling pathway 💬
 [1] PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin [1] 168 💬
114 MAPK signaling pathway 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
115 MAPK signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
116 MAPK signaling pathway 💬
 [3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [4] 51, 85, 222, 274 💬
117 MAPK signaling pathway 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [21] 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
118 MAPK signaling pathway 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [7] 37, 46, 49, 96, 107, 226, 271 💬
119 MAPK signaling pathway 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
120 MAPK signaling pathway 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
121 MAPK signaling pathway 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
122 MAPK signaling pathway 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
123 MAPK signaling pathway 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
124 MAPK signaling pathway 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
125 MAPK signaling pathway 💬
 [1] TNF 💬 Pomalidomide 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
126 MAPK signaling pathway 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [21]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
127 MAPK signaling pathway 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [8] 13, 34, 85, 87, 89, 227, 280, 331 💬
128 MAPK signaling pathway 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬