Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Ras signaling pathway 💬
 [1] ABL1 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
2 Ras signaling pathway 💬
 [1] ABL1 💬 Bosutinib hydrate 💬 Bosutinib [2]  2 , 67 💬
3 Ras signaling pathway 💬
 [1] ABL1 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
4 Ras signaling pathway 💬
 [4] ABL1, EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
5 Ras signaling pathway 💬
 [4] ABL1, EPHA2, KIT, PDGFRB 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
6 Ras signaling pathway 💬
 [3] ABL1, KIT, PDGFRA 💬 Imatinib mesylate 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
7 Ras signaling pathway 💬
 [3] ABL1, KIT, PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
8 Ras signaling pathway 💬
 [4] ABL1, KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
9 Ras signaling pathway 💬
 [1] CSF1R 💬 Axatilimab 💬 Axatilimab [1] 85 💬
10 Ras signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib malate 💬 Sunitinib [2] 28, 34 💬
11 Ras signaling pathway 💬
 [8] CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
12 Ras signaling pathway 💬
 [1] EGFR 💬 Afatinib 💬 Afatinib [1] 285 💬
13 Ras signaling pathway 💬
 [1] EGFR 💬 Afatinib dimaleate 💬 Afatinib [1] 285 💬
14 Ras signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
15 Ras signaling pathway 💬
 [1] EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib [2] 94, 160 💬
16 Ras signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [2] 94, 160 💬
17 Ras signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
18 Ras signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
19 Ras signaling pathway 💬
 [1] EGFR 💬 Lapatinib ditosylate 💬 Lapatinib [3] 34, 74, 75 💬
20 Ras signaling pathway 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
21 Ras signaling pathway 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
22 Ras signaling pathway 💬
 [1] EGFR 💬 Neratinib maleate 💬 Neratinib [1] 34 💬
23 Ras signaling pathway 💬
 [3] EGFR, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
24 Ras signaling pathway 💬
 [1] FGF19 💬 Aldafermin 💬 Aldafermin [1] 94 💬
25 Ras signaling pathway 💬
 [1] FGF23 💬 Burosumab 💬 Burosumab [1] 238 💬
26 Ras signaling pathway 💬
 [3] FGFR1, FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib [1] 276 💬
27 Ras signaling pathway 💬
 [3] FGFR1, FGFR2, FGFR3 💬 Infigratinib phosphate 💬 Infigratinib [1] 276 💬
28 Ras signaling pathway 💬
 [10] FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Catequentinib 💬 Anlotinib [1] 85 💬
29 Ras signaling pathway 💬
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
30 Ras signaling pathway 💬
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
31 Ras signaling pathway 💬
 [1] FGFR2 💬 Palifermin 💬 Palifermin [6] 13, 36, 38, 39, 65, 96 💬
32 Ras signaling pathway 💬
 [1] FGFR3 💬 Recifercept 💬 Recifercept [1] 276 💬
33 Ras signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
34 Ras signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
35 Ras signaling pathway 💬
 [3] FLT1, FLT4, KDR 💬 Cediranib maleate 💬 Cediranib [1] 34 💬
36 Ras signaling pathway 💬
 [6] FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Pazopanib hydrochloride 💬 Pazopanib [1] 227 💬
37 Ras signaling pathway 💬
 [1] FLT3 💬 Pacritinib 💬 Pacritinib [1] 331 💬
38 Ras signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib tosylate 💬 Sorafenib [2] 34, 86 💬
39 Ras signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
40 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Acamprosate calcium 💬 Acamprosate [2]  6 , 206 💬
41 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Acamprosate 💬 Acamprosate [2]  6 , 206 💬
42 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Amantadine hydrochloride 💬 Amantadine [5]  2 ,  6 ,  8 , 13, 127 💬
43 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Amantadine 💬 Amantadine [5]  2 ,  6 ,  8 , 13, 127 💬
44 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Dextromethorphan hydrobromide 💬 Dextromethorphan [10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
45 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
46 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine [7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬
47 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Esketamine hydrochloride 💬 Esketamine [7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬
48 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Ketamine hydrochloride 💬 Ketamine [6]  6 , 13, 70, 113, 156, 215 💬
49 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Ketamine 💬 Ketamine [6]  6 , 13, 70, 113, 156, 215 💬
50 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Latrepirdine 💬 Latrepirdine [1]  8  💬
51 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Latrepirdine dihydrochloride 💬 Latrepirdine [1]  8  💬
52 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Memantine hydrochloride 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
53 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Memantine 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
54 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Methadone hydrochloride 💬 Methadone [1] 60 💬
55 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Methadone 💬 Methadone [1] 60 💬
56 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [8]  2 ,  3 ,  5 ,  8 , 13, 17, 203, 206 💬
57 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Tenocyclidine 💬 Tenocyclidine [1] 36 💬
58 Ras signaling pathway 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
59 Ras signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [4] 96, 168, 265, 299 💬
60 Ras signaling pathway 💬
 [1] IGF1R 💬 Mecasermin rinfabate 💬 Mecasermin [4] 96, 168, 265, 299 💬
61 Ras signaling pathway 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
62 Ras signaling pathway 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
63 Ras signaling pathway 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [1] 156 💬
64 Ras signaling pathway 💬
 [1] INSR 💬 Insulin lispro 💬 Insulin lispro [1] 53 💬
65 Ras signaling pathway 💬
 [2] KDR, MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
66 Ras signaling pathway 💬
 [2] KDR, MET 💬 Cabozantinib s-malate 💬 Cabozantinib [1] 34 💬
67 Ras signaling pathway 💬
 [1] KIT 💬 Barzolvolimab 💬 Barzolvolimab [1] 98 💬
68 Ras signaling pathway 💬
 [1] KIT 💬 Masitinib 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
69 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
70 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
71 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib [1] 280 💬
72 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [4] 34, 278, 279, 280 💬
73 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
74 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib [1] 34 💬
75 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
76 Ras signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
77 Ras signaling pathway 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [6] 46, 49, 51, 53, 271, 300 💬
78 Ras signaling pathway 💬
 [1] NGFB 💬 Tanezumab 💬 Tanezumab [2] 226, 298 💬
79 Ras signaling pathway 💬
 [1] NGFR 💬 Cenegermin 💬 Cenegermin [1] 53 💬
80 Ras signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 Seralutinib 💬 Seralutinib [1] 86 💬
81 Ras signaling pathway 💬
 [3] PGF, VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
82 Ras signaling pathway 💬
 [1] PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib [4] 138, 278, 279, 280 💬
83 Ras signaling pathway 💬
 [1] PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib [2] 53, 65 💬
84 Ras signaling pathway 💬
 [1] PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
85 Ras signaling pathway 💬
 [2] PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib [1] 121 💬
86 Ras signaling pathway 💬
 [3] PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
87 Ras signaling pathway 💬
 [1] PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin [1] 168 💬
88 Ras signaling pathway 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
89 Ras signaling pathway 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
90 Ras signaling pathway 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [8] 13, 34, 85, 87, 89, 227, 280, 331 💬
91 Ras signaling pathway 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬