Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Prion disease 💬
 [1] C5 💬 Avacincaptad pegol sodium 💬 Avacincaptad pegol [1] 301 💬
2 Prion disease 💬
 [1] C5 💬 Crovalimab 💬 Crovalimab [3] 48, 62, 109 💬
3 Prion disease 💬
 [1] C5 💬 Eculizumab 💬 Eculizumab [8] 11, 13, 14, 61, 62, 109, 221, 223 💬
4 Prion disease 💬
 [1] C5 💬 Gefurulimab 💬 Gefurulimab [1] 11 💬
5 Prion disease 💬
 [1] C5 💬 Nomacopan 💬 Nomacopan [1] 162 💬
6 Prion disease 💬
 [1] C5 💬 Pozelimab 💬 Pozelimab [3] 11, 15, 62 💬
7 Prion disease 💬
 [1] C5 💬 Ravulizumab 💬 Ravulizumab [8]  2 , 11, 13, 50, 62, 66, 109, 224 💬
8 Prion disease 💬
 [1] C5 💬 Vilobelimab 💬 Vilobelimab [3] 43, 44, 269 💬
9 Prion disease 💬
 [1] C5 💬 Zilucoplan sodium 💬 Zilucoplan [3]  2 , 11, 62 💬
10 Prion disease 💬
 [1] C5 💬 Zilucoplan 💬 Zilucoplan [3]  2 , 11, 62 💬
11 Prion disease 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
12 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine besylate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
13 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine maleate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
14 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
15 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine benzoate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
16 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Benidipine hydrochloride 💬 Benidipine [1] 57 💬
17 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Benidipine 💬 Benidipine [1] 57 💬
18 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Bevantolol hydrochloride 💬 Bevantolol [1]  8  💬
19 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem hydrochloride 💬 Diltiazem [4] 51, 58, 86, 88 💬
20 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem malate 💬 Diltiazem [4] 51, 58, 86, 88 💬
21 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [4] 51, 58, 86, 88 💬
22 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
23 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine hydrochloride 💬 Nicardipine [2] 70, 86 💬
24 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
25 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
26 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
27 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline maleate 💬 Perhexiline [2] 58, 272 💬
28 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
29 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine hydrochloride 💬 Propiverine [1] 226 💬
30 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
31 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
32 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil hydrochloride 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
33 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
34 Prion disease 💬
 [1] CACNA1S 💬 Pinaverium bromide 💬 Pinaverium [1] 298 💬
35 Prion disease 💬
 [1] CASP9 💬 Rimiducid 💬 Rimiducid [7] 19, 49, 60, 65, 284, 285, 326 💬
36 Prion disease 💬
 [1] FYN 💬 Dasatinib 💬 Dasatinib [3] 13, 51, 85 💬
37 Prion disease 💬
 [1] FYN 💬 Dasatinib 💬 Dasatinib [3] 13, 51, 85 💬
38 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Acamprosate calcium 💬 Acamprosate [3]  2 ,  6 , 206 💬
39 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Acamprosate 💬 Acamprosate [3]  2 ,  6 , 206 💬
40 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amantadine hydrochloride 💬 Amantadine [5]  2 ,  6 ,  8 , 13, 127 💬
41 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amantadine 💬 Amantadine [5]  2 ,  6 ,  8 , 13, 127 💬
42 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan hydrobromide 💬 Dextromethorphan [10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
43 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
44 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan polistirex 💬 Dextromethorphan [10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
45 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine [7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬
46 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine [7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬
47 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Ketamine hydrochloride 💬 Ketamine [6]  6 , 13, 70, 113, 156, 215 💬
48 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Ketamine 💬 Ketamine [6]  6 , 13, 70, 113, 156, 215 💬
49 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Latrepirdine 💬 Latrepirdine [1]  8  💬
50 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Latrepirdine dihydrochloride 💬 Latrepirdine [1]  8  💬
51 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
52 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
53 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Methadone hydrochloride 💬 Methadone [1] 60 💬
54 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Methadone 💬 Methadone [1] 60 💬
55 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
56 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Troriluzole 💬 Troriluzole [1] 18 💬
57 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Troriluzole hydrochloride 💬 Troriluzole [1] 18 💬
58 Prion disease 💬
 [1] GRIN2B 💬 Radiprodil 💬 Radiprodil [3] 137, 145, 158 💬
59 Prion disease 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬
60 Prion disease 💬
 [1] IL1A 💬 Vilamakitug 💬 Vilamakitug [1] 271 💬
61 Prion disease 💬
 [2] IL1A, IL1B 💬 Lutikizumab 💬 Lutikizumab [3] 46, 96, 97 💬
62 Prion disease 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [5] 51, 84, 106, 107, 266 💬
63 Prion disease 💬
 [4] IL1A, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [12] 13, 34, 40, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
64 Prion disease 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [11] 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
65 Prion disease 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
66 Prion disease 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
67 Prion disease 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
68 Prion disease 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
69 Prion disease 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
70 Prion disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
71 Prion disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
72 Prion disease 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [4] 138, 278, 279, 280 💬
73 Prion disease 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
74 Prion disease 💬
 [2] PIK3CA, PIK3CD 💬 Copanlisib 💬 Copanlisib [1] 121 💬
75 Prion disease 💬
 [1] PIK3CD 💬 Leniolisib phosphate 💬 Leniolisib [2] 53, 65 💬
76 Prion disease 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
77 Prion disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [39] 11, 14, 19, 20, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 61, 62, 63, 64, 65, 67, 90, 95, 97, 107, 118, 162, 164, 222, 223, 226, 228, 234, 283, 284, 285, 302 💬
78 Prion disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬
79 Prion disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [37]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
80 Prion disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [37]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
81 Prion disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬
82 Prion disease 💬
 [1] PRKCD 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
83 Prion disease 💬
 [1] PRKCD 💬 Sotrastaurin acetate 💬 Sotrastaurin [1] 97 💬
84 Prion disease 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [19] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 172, 222, 223, 228, 256, 283, 288, 331 💬
85 Prion disease 💬
 [1] PSMB5 💬 Carfilzomib 💬 Carfilzomib [2] 16, 28 💬
86 Prion disease 💬
 [1] PSMB5 💬 Ixazomib 💬 Ixazomib [4] 13, 16, 28, 51 💬
87 Prion disease 💬
 [1] PSMB5 💬 Ixazomib citrate 💬 Ixazomib [4] 13, 16, 28, 51 💬
88 Prion disease 💬
 [1] SOD1 💬 Tofersen 💬 Tofersen [1]  2  💬
89 Prion disease 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [22] 19, 37, 38, 40, 41, 46, 55, 56, 84, 90, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
90 Prion disease 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [10] 37, 40, 46, 48, 49, 96, 97, 107, 226, 271 💬
91 Prion disease 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
92 Prion disease 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
93 Prion disease 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 162, 164, 223, 269, 270, 271 💬
94 Prion disease 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [9] 16, 26, 28, 34, 49, 56, 284, 300, 331 💬
95 Prion disease 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
96 Prion disease 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
97 Prion disease 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [22]  2 , 16, 20, 28, 49, 51, 53, 56, 63, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
98 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Belantamab mafodotin 💬 Belantamab mafodotin [2] 28, 63 💬
99 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Brentuximab vedotin 💬 Brentuximab vedotin [2] 49, 51 💬
100 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Colchicine 💬 Colchicine [9]  2 , 42, 46, 50, 56, 93, 97, 210, 266 💬
101 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Paclitaxel 💬 Paclitaxel [2] 46, 85 💬
102 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vinblastine sulfate 💬 Vinblastine [3] 34, 63, 65 💬
103 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vinblastine 💬 Vinblastine [3] 34, 63, 65 💬
104 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vincristine sulfate 💬 Vincristine [5] 26, 34, 63, 65, 331 💬
105 Prion disease 💬
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vincristine 💬 Vincristine [5] 26, 34, 63, 65, 331 💬