127. 前頭側頭葉変性症 Disease details / Clinical trials / Drug dev / DR info

13c6 leucine
   Washington University School of Medicine
      2017   -   NCT03545126   United States
18F-AV-1451
   Columbia University
      2016   Phase 2   NCT02676843   United States
   Skåne University Hospital, Region Skåne
      2014   Phase 2   EUCTR2014-000422-38-SE   Sweden
   VU University Medical Center
      2016   Phase 2   EUCTR2015-005604-29-NL   Netherlands
18F-AV-45
   Avid Radiopharmaceuticals, Inc
      2009   Phase 2   EUCTR2008-003597-18-GB   United Kingdom
18F-FDG
   Avid Radiopharmaceuticals
      2009   Phase 2   NCT01890343   United Kingdom
18F-RO6958948
   Skåne University Hospital
      2017   Phase 2   EUCTR2017-000094-36-SE   Sweden
3 tesla MRI
   IRCCS San Raffaele
      2021   -   NCT06826157   Italy
Adeno-associated viral vector serotype 9 expressing codon-optimized human GRN gene
   Prevail Therapeutics, a wholly-owned subsidiary of Eli Lilly and Company
      2022   Phase 1;Phase 2   EUCTR2019-003159-12-FR   Australia;Belgium;France;Spain;United Kingdom;United States
      2021   Phase 1;Phase 2   EUCTR2019-003159-12-BE   Australia;Belgium;France;Spain;United Kingdom;United States
AL-108
   University of California, San Francisco
      2010   Phase 1   NCT01056965   United States
AL001
   Alector Inc.
      2021   Phase 3   EUCTR2019-004066-18-FR   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-SE   Argentina;Australia;Belgium;Canada;France;Germany;Greece;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;Türkiye;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-PT   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-NL   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-IT   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-GB   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-ES   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-DE   Argentina;Australia;Belgium;Canada;France;Germany;Greece;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;Türkiye;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-BE   Argentina;Australia;Belgium;Canada;France;Germany;Greece;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;Türkiye;United Kingdom;United States
      2019   Phase 2   NCT03987295   Canada;Germany;Italy;Netherlands;United Kingdom;United States
      2019   Phase 2   EUCTR2019-000138-20-NL   Canada;Germany;Italy;Netherlands;United Kingdom;United States
      2019   Phase 2   EUCTR2019-000138-20-IT   Canada;Germany;Italy;Netherlands;United Kingdom;United States
      2019   Phase 2   EUCTR2019-000138-20-GB   Canada;Germany;Italy;Netherlands;United Kingdom;United States
      2019   Phase 2   EUCTR2019-000138-20-DE   Canada;Germany;Italy;Netherlands;United Kingdom;United States
      2018   Phase 1   NCT03636204   Canada;Netherlands;United Kingdom;United States
Amantadine
   Johns Hopkins University
      2005   Phase 4   NCT00127114   United States
Amiodarone
   AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA
      2012   -   EUCTR2011-004571-37-IT   Italy
Amyvid
   IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
      2014   Phase 3   EUCTR2014-001315-40-IT   Italy
Apolipoprotein E genetic test
   IRCCS San Raffaele
      2021   -   NCT06826157   Italy
AV1451 TAU
   Mayo Clinic
      2020   -   NCT04680130   United States
AVB-101
   AVIADOBIO LTD
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-IT   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
   AviadoBio Ltd
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-SE   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-FR   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-BE   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
BIIB092
   University of California, San Francisco
      2018   Phase 1   NCT03658135   United States
Blood sample
   University Hospital, Lille
      2022   -   NCT05288842   France
Brain PET scan
   Avid Radiopharmaceuticals
      2017   Phase 1   NCT03040713   United States
C-11 ER176
   Mayo Clinic
      2020   -   NCT04680130   United States
C-11 PIB
   Mayo Clinic
      2020   -   NCT04680130   United States
      2010   Phase 1   NCT01623284   United States
      2008   Phase 4   NCT00950430   United States
Censavudine
   Transposon Therapeutics, Inc
      2022   Phase 2   EUCTR2021-002251-11-FR   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2021-002251-11-ES   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2021-002251-11-BE   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
      2021   Phase 2   EUCTR2021-002251-11-DE   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
Citalopram
   Sunnybrook Health Sciences Centre
      2006   Phase 4   NCT00376051   Canada
Cognitive and behavioral experimental tasks
   Institut National de la Santé Et de la Recherche Médicale, France
      2017   -   NCT03272230   France
Davunetide
   University of California, San Francisco
      2010   Phase 1   NCT01056965   United States
DNL593
   Denali Therapeutics Inc.
      2022   Phase 1/Phase 2   NCT05262023   Belgium;Brazil;Colombia;Czechia;France;Italy;Netherlands;Portugal;Serbia;Spain;Turkey;United Kingdom;United States
DNL593 sterile lyophilisate
   Denali Therapeutics Inc.
      2023   Phase 1;Phase 2   EUCTR2021-005733-16-PT   Argentina;Belgium;Brazil;Colombia;Czech Republic;Czechia;France;Hungary;Italy;Netherlands;Portugal;Serbia;Spain;Sweden;Turkey;United Kingdom;United States
      2023   Phase 1;Phase 2   EUCTR2021-005733-16-IT   Argentina;Belgium;Brazil;Colombia;Czechia;France;Hungary;Italy;Netherlands;Portugal;Serbia;Spain;Sweden;Turkey;United Kingdom;United States
      2023   Phase 1;Phase 2   EUCTR2021-005733-16-CZ   Belgium;Brazil;Colombia;Czech Republic;Czechia;France;Italy;Netherlands;Portugal;Serbia;Spain;Turkey;United Kingdom;United States
      2022   Phase 1;Phase 2   EUCTR2021-005733-16-NL   Belgium;Brazil;Colombia;Czech Republic;Czechia;France;Italy;Netherlands;Portugal;Serbia;Spain;Turkey;United Kingdom;United States
      2022   Phase 1;Phase 2   EUCTR2021-005733-16-FR   Argentina;Belgium;Brazil;Colombia;Czech Republic;Czechia;France;Hungary;Italy;Netherlands;Portugal;Serbia;Spain;Sweden;Turkey;United Kingdom;United States
      2022   Phase 1;Phase 2   EUCTR2021-005733-16-ES   Argentina;Belgium;Brazil;Colombia;Czechia;France;Italy;Netherlands;Portugal;Serbia;Spain;Sweden;Turkey;United Kingdom;United States
Donepezil
   National Hospital Organization Kikuchi Hospital
      2008   -   JPRN-UMIN000003239   Japan
DPA
   Erasmus Medical Center
      2020   Phase 2   EUCTR2020-002672-12-NL   Netherlands
Ecocapture
   Institut National de la Santé Et de la Recherche Médicale, France
      2017   -   NCT03272230   France
Elecsys (roche) abeta42, ttau and ptau
   Skane University Hospital
      2017   -   NCT03174938   Sweden
Electroencephalogram
   IRCCS San Raffaele
      2021   -   NCT06826157   Italy
ET-stem
   Samsung Medical Center
      2022   Phase 1   NCT05315661   Korea, Republic of
EVP-0334
   FORUM Pharmaceuticals Inc.
      2015   Phase 2;Phase 3   EUCTR2014-001489-85-GB   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-001489-85-BE   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2014   Phase 2   EUCTR2014-001489-85-NL   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2014   Phase 2   EUCTR2014-001489-85-IT   Belgium;France;Italy;Netherlands;United Kingdom;United States
F 18 T807
   Tammie L. S. Benzinger, MD, PhD
      2017   Phase 2   NCT02707978   United States
F-18
   Chang Gung Memorial Hospital
      2018   Early Phase 1   NCT03625128   Taiwan
   Skåne University Hospital
      2017   Phase 2   EUCTR2017-000094-36-SE   Sweden
F-18 AV 1451
   Mayo Clinic
      2016   -   NCT02736695   United States
F-18 FDG
   Mayo Clinic
      2010   Phase 1   NCT01623284   United States
      2008   Phase 4   NCT00950430   United States
Ferulic acid
   Shimane University Hospital
      2010   -   JPRN-UMIN000003683   Japan
Florbetapir 18F
   Avid Radiopharmaceuticals
      2009   Phase 2   NCT01890343   United Kingdom
Florbetapir 18F injection
   Avid Radiopharmaceuticals, Inc
      2009   Phase 2   EUCTR2008-003597-18-GB   United Kingdom
Flortaucipir F18
   Avid Radiopharmaceuticals
      2017   Phase 1   NCT03040713   United States
Flutemetamol
   Skåne University Hospital
      2017   Phase 2   EUCTR2017-000094-36-SE   Sweden
Flutemetamol F18 injection
   Skane University Hospital
      2017   -   NCT03174938   Sweden
FPI-2620
   University of Pennsylvania
      2022   Phase 3   NCT05456503   United States
FRM-0334
   FORUM Pharmaceuticals Inc
      2014   Phase 2   NCT02149160   Belgium;France;Italy;Netherlands;United Kingdom;United States
   FORUM Pharmaceuticals Inc.
      2015   Phase 2;Phase 3   EUCTR2014-001489-85-GB   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-001489-85-BE   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2014   Phase 2   EUCTR2014-001489-85-NL   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2014   Phase 2   EUCTR2014-001489-85-IT   Belgium;France;Italy;Netherlands;United Kingdom;United States
Galantamine hydrobromide
   Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
      2003   Phase 2   NCT00416169   -
Histone deacetylase inhibitor
   FORUM Pharmaceuticals Inc.
      2015   Phase 2;Phase 3   EUCTR2014-001489-85-GB   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2015   Phase 2   EUCTR2014-001489-85-BE   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2014   Phase 2   EUCTR2014-001489-85-NL   Belgium;France;Italy;Netherlands;United Kingdom;United States
      2014   Phase 2   EUCTR2014-001489-85-IT   Belgium;France;Italy;Netherlands;United Kingdom;United States
Icm_apathy_tasks
   Institut National de la Santé Et de la Recherche Médicale, France
      2017   -   NCT03272230   France
Injection
   AVIADOBIO LTD
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-IT   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
   IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
      2014   Phase 3   EUCTR2014-001315-40-IT   Italy
   Kagawa University
      2021   -   JPRN-UMIN000043737   Japan
   OSPEDALE S. RAFFAELE DI MILANO
      2013   -   EUCTR2012-004328-40-IT   Italy
   Prevail Therapeutics, a wholly-owned subsidiary of Eli Lilly and Company
      2022   Phase 1;Phase 2   EUCTR2019-003159-12-FR   Australia;Belgium;France;Spain;United Kingdom;United States
      2021   Phase 1;Phase 2   EUCTR2019-003159-12-BE   Australia;Belgium;France;Spain;United Kingdom;United States
   Skåne University Hospital
      2017   Phase 2   EUCTR2017-000094-36-SE   Sweden
   Skåne University Hospital, Region Skåne
      2014   Phase 2   EUCTR2014-000422-38-SE   Sweden
   VU University Medical Center
      2016   Phase 2   EUCTR2015-005604-29-NL   Netherlands
   Wave Life Sciences UK Limited
      2023   Phase 1;Phase 2   EUCTR2022-002267-29-BE   Australia;Belgium;Canada;Ireland;Netherlands;New Zealand;United Kingdom
      2022   Phase 1;Phase 2   EUCTR2020-005193-94-SE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
      2022   Phase 1;Phase 2   EUCTR2020-005193-94-BE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
      2021   Phase 1;Phase 2   EUCTR2020-005193-94-DE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
Intranasal oxytocin
   Lawson Health Research Institute
      2013   Phase 2   NCT01937013   Canada
      2009   -   NCT01002300   Canada
Intrathalamic AAV.pgrn administration
   AviadoBio Ltd
      2023   Phase 1/Phase 2   NCT06064890   Netherlands;Poland;Spain;Sweden;United Kingdom;United States
Intrathalamic AVB-101
   AviadoBio Ltd
      2023   Phase 1/Phase 2   NCT06064890   Netherlands;Poland;Spain;Sweden;United Kingdom;United States
Ketogenic diet
   Xuanwu Hospital, Beijing
      2025   -   NCT06761729   -
Latozinemab
   Alector Inc.
      2020   Phase 3   EUCTR2019-004066-18-SE   Argentina;Australia;Belgium;Canada;France;Germany;Greece;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;Türkiye;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-PT   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-NL   Australia;Belgium;Canada;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-DE   Argentina;Australia;Belgium;Canada;France;Germany;Greece;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;Türkiye;United Kingdom;United States
      2020   Phase 3   EUCTR2019-004066-18-BE   Argentina;Australia;Belgium;Canada;France;Germany;Greece;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;Türkiye;United Kingdom;United States
      2019   Phase 2   EUCTR2019-000138-20-NL   Canada;Germany;Italy;Netherlands;United Kingdom;United States
      2019   Phase 2   EUCTR2019-000138-20-DE   Canada;Germany;Italy;Netherlands;United Kingdom;United States
Lemborexant 5 MG
   Nova Scotia Health Authority
      2023   Phase 4   NCT06093126   Canada
Lithium carbonate
   Columbia University
      2017   Phase 2   NCT02862210   United States
Lmtm
   TauRx Therapeutics Ltd
      2014   Phase 3   NCT02245568   Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
Lmtm/TRX0237
   TauRx Therapeutics Ltd
      2016   Phase 3   EUCTR2014-002013-37-NL   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-HR   Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-FI   Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-ES   Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-BE   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2014-002013-37-GB   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-PL   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-IT   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-HR   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-FI   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-ES   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2013   Phase 3   EUCTR2011-005529-34-NL   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2013   Phase 3   EUCTR2011-005529-34-GB   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2012   Phase 3   EUCTR2011-005529-34-DE   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
Lumbar puncture
   University Hospital, Lille
      2022   -   NCT05288842   France
Lumipulse (fujirebio) abeta42, ttau and ptau
   Skane University Hospital
      2017   -   NCT03174938   Sweden
LY3884963
   Prevail Therapeutics
      2020   Phase 1/Phase 2   NCT04408625   Australia;Belgium;France;Spain;United Kingdom;United States
   Prevail Therapeutics, a wholly-owned subsidiary of Eli Lilly and Company
      2021   Phase 1;Phase 2   EUCTR2019-003159-12-BE   Australia;Belgium;France;Spain;United Kingdom;United States
Memantine
   Nantes University Hospital
      2005   Phase 2   NCT00200538   France
   University of California, San Francisco
      2007   Phase 4   NCT00545974   United States
      2004   Phase 4   NCT00187525   -
Memantine hydrochloride
   Tiffany Chow, MD
      2007   Phase 3   NCT00594737   Canada
Metformin
   University of Florida
      2020   Phase 2   NCT04220021   United States
Methylprednisolone
   Prevail Therapeutics
      2020   Phase 1/Phase 2   NCT04408625   Australia;Belgium;France;Spain;United Kingdom;United States
Methylthioninium
   TauRx Therapeutics Ltd
      2016   Phase 3   EUCTR2014-002013-37-NL   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-HR   Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-FI   Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-ES   Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-BE   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2014-002013-37-GB   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-PL   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-IT   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-HR   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-FI   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-ES   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2013   Phase 3   EUCTR2011-005529-34-NL   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2013   Phase 3   EUCTR2011-005529-34-GB   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2012   Phase 3   EUCTR2011-005529-34-DE   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
Methylthioninium chloride
   TauRx Therapeutics PTE Ltd
      2006   Phase 2   EUCTR2005-005915-13-GB   United Kingdom
MTC TRX0014-001 capsules
   TauRx Therapeutics PTE Ltd
      2006   Phase 2   EUCTR2005-005915-13-GB   United Kingdom
Nabilone
   Simon Ducharme, MD
      2023   Phase 2   NCT05742698   Canada
Neupro - 2 MG/24 H + 4 MG/24 H + 6 MG/24 H+ 8 MG/24 H cerotto otto transdermico 7 cerotti + 7 cerotti + 7 cerotti + 7 cerotti trandermici IN bustina
   I.R.C.C.S. FONDAZIONE S.LUCIA
      2021   Phase 2   EUCTR2019-002997-30-IT   Italy
Neurohormonal mechanisms
   Institut National de la Santé Et de la Recherche Médicale, France
      2017   -   NCT03272230   France
Neuropsychological assessment
   Institut National de la Santé Et de la Recherche Médicale, France
      2017   -   NCT03272230   France
Novolin-R insulin
   HealthPartners Institute
      2019   Phase 2   NCT04115384   United States
Open label - AL001
   Alector Inc.
      2020   Phase 3   NCT04374136   Argentina;Australia;Belgium;Canada;France;Germany;Greece;Italy;Netherlands;Portugal;Spain;Sweden;Switzerland;Turkey;United Kingdom;United States
Optional prednisone
   Prevail Therapeutics
      2020   Phase 1/Phase 2   NCT04408625   Australia;Belgium;France;Spain;United Kingdom;United States
Optional sirolimus
   Prevail Therapeutics
      2020   Phase 1/Phase 2   NCT04408625   Australia;Belgium;France;Spain;United Kingdom;United States
Ossitocina
   ALMA MATER STUDIORUM UNIVERSITà DI BOLOGNA
      2019   Phase 2   EUCTR2018-000143-12-IT   Italy
Oxytocin
   Lawson Health Research Institute
      2011   Phase 1   NCT01386333   Canada
PBFT02
   Passage Bio, Inc.
      2021   Phase 1/Phase 2   NCT04747431   Brazil;Canada;Italy;Portugal;United Kingdom;United States
PEA-LUT
   I.R.C.C.S. Fondazione Santa Lucia
      2019   Phase 2   NCT04489017   Italy
PET/CT
   David Wilson
      2021   Phase 1/Phase 2   NCT05374278   United States
   Kagawa University
      2021   -   JPRN-UMIN000043737   Japan
Phenothiazine
   TauRx Therapeutics Ltd
      2016   Phase 3   EUCTR2014-002013-37-NL   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-HR   Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-FI   Australia;Belgium;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-ES   Argentina;Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2015   Phase 3   EUCTR2014-002013-37-BE   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Italy;Korea, Republic of;Malaysia;Netherlands;Poland;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2014-002013-37-GB   Australia;Belgium;Bulgaria;Canada;Croatia;Finland;France;Germany;Korea, Republic of;Malaysia;Netherlands;Romania;Russian Federation;Singapore;Spain;Taiwan;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-PL   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-IT   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-HR   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-FI   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2014   Phase 3   EUCTR2011-005529-34-ES   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2013   Phase 3   EUCTR2011-005529-34-NL   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Singapore;Spain;United Kingdom;United States
      2013   Phase 3   EUCTR2011-005529-34-GB   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
      2012   Phase 3   EUCTR2011-005529-34-DE   Australia;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
Pittsburgh compound B
   Mayo Clinic
      2008   Phase 4   NCT00950430   United States
PR006A
   Prevail Therapeutics, a wholly-owned subsidiary of Eli Lilly and Company
      2022   Phase 1;Phase 2   EUCTR2019-003159-12-FR   Australia;Belgium;France;Spain;United Kingdom;United States
      2021   Phase 1;Phase 2   EUCTR2019-003159-12-BE   Australia;Belgium;France;Spain;United Kingdom;United States
Probiotic
   Centre hospitalier de l'Université de Montréal (CHUM)
      2024   -   NCT06051123   Canada
Recombinant AAV-9 vector expressing THE human progranulin protein
   AVIADOBIO LTD
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-IT   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
   AviadoBio Ltd
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-SE   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-FR   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
      2023   Phase 1;Phase 2   EUCTR2022-002568-62-BE   Belgium;France;Italy;Netherlands;Poland;Spain;Sweden;United Kingdom;United States
Rotigotina
   I.R.C.C.S. FONDAZIONE S.LUCIA
      2021   Phase 2   EUCTR2019-002997-30-IT   Italy
Rotigotine
   I.R.C.C.S. FONDAZIONE S.LUCIA
      2021   Phase 2   EUCTR2019-002997-30-IT   Italy
Rotigotine 4MG/24HRS patch
   I.R.C.C.S. Fondazione Santa Lucia
      2021   Phase 2   NCT04937452   Italy
Rotigotine 6MG/24HRS patch
   I.R.C.C.S. Fondazione Santa Lucia
      2021   Phase 2   NCT04937452   Italy
Saline nasal mist
   Lawson Health Research Institute
      2013   Phase 2   NCT01937013   Canada
      2011   Phase 1   NCT01386333   Canada
Synthetic stereopure antisense oligonucleotide targeting human C9orf72 hexanucleotide repeat-containing mrna transcripts
   Wave Life Sciences UK Limited
      2023   Phase 1;Phase 2   EUCTR2022-002267-29-BE   Australia;Belgium;Canada;Ireland;Netherlands;New Zealand;United Kingdom
      2022   Phase 1;Phase 2   EUCTR2020-005193-94-SE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
      2022   Phase 1;Phase 2   EUCTR2020-005193-94-BE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
      2021   Phase 1;Phase 2   EUCTR2020-005193-94-DE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
Syntocinon
   ALMA MATER STUDIORUM UNIVERSITà DI BOLOGNA
      2019   Phase 2   EUCTR2018-000143-12-IT   Italy
   Lawson Health Research Institute
      2018   Phase 2   NCT03260920   Canada;United States
T807
   VU University Medical Center
      2016   Phase 2   EUCTR2015-005604-29-NL   Netherlands
TBC
   Prevail Therapeutics, a wholly-owned subsidiary of Eli Lilly and Company
      2022   Phase 1;Phase 2   EUCTR2019-003159-12-FR   Australia;Belgium;France;Spain;United Kingdom;United States
      2021   Phase 1;Phase 2   EUCTR2019-003159-12-BE   Australia;Belgium;France;Spain;United Kingdom;United States
THK-5351
   Kagawa University
      2021   -   JPRN-UMIN000043737   Japan
   Nagoya University Department of Neurology
      2015   -   JPRN-UMIN000018496   Japan
Tolcapone
   Columbia University
      2011   Phase 2   NCT00604591   United States
TPN-101
   Transposon Therapeutics, Inc
      2022   Phase 2   EUCTR2021-002251-11-FR   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2021-002251-11-ES   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
      2022   Phase 2   EUCTR2021-002251-11-BE   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
      2021   Phase 2   EUCTR2021-002251-11-DE   Belgium;Canada;France;Germany;Netherlands;Spain;United Kingdom;United States
TPN-101, 400 MG/DAY
   Transposon Therapeutics, Inc.
      2021   Phase 2   NCT04993755   Belgium;France;Germany;Netherlands;Spain;United States
TRX0237
   TauRx Therapeutics Ltd
      2013   Phase 3   NCT01626378   Argentina;Australia;Bulgaria;Canada;Croatia;Finland;Germany;Italy;Netherlands;Poland;Romania;Singapore;Spain;United Kingdom;United States
Verdiperstat
   Peter Ljubenkov, MD
      2022   Phase 1   NCT05184569   United States
VES001
   Mads Kjolby
      2024   Phase 1   NCT06705192   Netherlands;United Kingdom
Vizamyl
   Skåne University Hospital
      2017   Phase 2   EUCTR2017-000094-36-SE   Sweden
Vortioxetine
   Johns Hopkins University
      2025   Phase 2   NCT06604520   United States
Whole exome sequencing
   Neuromed IRCCS
      2025   -   NCT06803784   Italy
Whole genome sequencing
   Neuromed IRCCS
      2025   -   NCT06803784   Italy
WVE-004
   Wave Life Sciences Ltd.
      2022   Phase 1/Phase 2   NCT05683860   Netherlands;United Kingdom
      2021   Phase 1/Phase 2   NCT04931862   Australia;Belgium;Canada;Ireland;Netherlands;New Zealand;Sweden;United Kingdom
   Wave Life Sciences UK Limited
      2023   Phase 1;Phase 2   EUCTR2022-002267-29-BE   Australia;Belgium;Canada;Ireland;Netherlands;New Zealand;United Kingdom
      2022   Phase 1;Phase 2   EUCTR2020-005193-94-SE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
      2022   Phase 1;Phase 2   EUCTR2020-005193-94-BE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States
      2021   Phase 1;Phase 2   EUCTR2020-005193-94-DE   Australia;Belgium;Canada;Germany;Ireland;Netherlands;New Zealand;Sweden;United Kingdom;United States