Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Amantadine 3件: Amantadine; Amantadine hydrochloride; Amantadine sulfate2件: Amantadine hydrochloride ,
Amantadine 💬 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		21件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬5件: 2, 6, 8, 13, 127 💬
2 Amiodarone 1件: Amiodarone2件: Amiodarone hydrochloride ,
Amiodarone 💬 		16件: ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
KCND3,
KCNJ11,
KCNJ12_18,
KCNJ3,
KCNJ5,
KCNJ8,
KCNQ1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		34件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy, Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Hormone signaling, Insulin secretion, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 127 💬
3 AVB-101 1件: AVB-101---1件: 127 💬
4 Censavudine 1件: Censavudine1件: Censavudine 💬 --3件: 2, 127, 325 💬
5 Citalopram 1件: Citalopram2件: Citalopram hydrobromide ,
Citalopram 💬 		1件: SLC6A4 💬 3件: Neuroactive ligand signaling, Serotonergic synapse, Synaptic vesicle cycle 💬5件: 6, 13, 46, 98, 127 💬
6 Davunetide 1件: Davunetide1件: Davunetide 💬 --3件: 5, 7, 127 💬
7 Donepezil 2件: Donepezil; Donepezil hydrochloride2件: Donepezil hydrochloride ,
Donepezil 💬 		1件: ACHE 💬 3件: Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬8件: 5, 6, 13, 46, 124, 127, 156, 206 💬
8 Ferulic acid 1件: Ferulic acid---1件: 127 💬
9 Flortaucipir 0件: 1件: Flortaucipir F 18 💬 1件: MAPT 💬 4件: Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬3件: 5, 7, 127 💬
10 Fludeoxyglucose (18F) 2件: 18F-FDG; Fludeoxyglucose F 181件: Fludeoxyglucose F 18 💬 --12件: 5, 6, 7, 8, 34, 41, 46, 84, 85, 96, 127, 300 💬
11 Flutemetamol 1件: Flutemetamol---5件: 5, 6, 7, 17, 127 💬
12 Flutemetamol (18F) 1件: Flutemetamol1件: Flutemetamol F 18 💬 --5件: 5, 6, 7, 17, 127 💬
13 Galantamine 2件: Galantamine; Galantamine hydrobromide2件: Galantamine hydrobromide ,
Galantamine 💬 		1件: ACHE 💬 3件: Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬3件: 6, 11, 127 💬
14 Hydromethylthionine mesylate 1件: Lmtm1件: Hydromethylthionine mesylate 💬 1件: MAPT 💬 4件: Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬1件: 127 💬
15 Latozinemab 2件: AL001; Latozinemab1件: Latozinemab 💬 1件: SORT1 💬 3件: Cholesterol metabolism, Lysosome, Neurotrophin signaling pathway 💬2件: 2, 127 💬
16 Lemborexant 0件: 1件: Lemborexant 💬 2件: HCRTR1,
HCRTR2 💬 		2件: Hormone signaling, Neuroactive ligand-receptor interaction 💬1件: 127 💬
17 Lithium carbonate 1件: Lithium carbonate1件: Lithium carbonate 💬 --6件: 2, 13, 17, 18, 127, 310 💬
18 Memantine 2件: Memantine; Memantine hydrochloride2件: Memantine hydrochloride ,
Memantine 💬 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		21件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬8件: 2, 6, 8, 13, 49, 127, 205, 206 💬
19 Metformin 3件: Metformin; Metformin hydrochloride; Metformina2件: Metformin hydrochloride ,
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
20 Methylene blue 2件: Methylene blue; Methylthioninium chloride2件: Methylene blue ,
Methylthioninium chloride hydrate 💬 		--3件: 97, 127, 235 💬
21 Methylprednisolone 3件: Methylprednisolon; Methylprednisolone; Methylprednisolone acetate2件: Methylprednisolone ,
Methylprednisolone acetate 💬 		1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
22 Methylthioninium 1件: Methylthioninium---1件: 127 💬
23 Nabilone 1件: Nabilone1件: Nabilone 💬 2件: CNR1,
CNR2 💬 		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬4件: 6, 13, 97, 127 💬
24 Oxytocin 1件: Oxytocin1件: Oxytocin 💬 1件: OXTR 💬 5件: Calcium signaling pathway, Hormone signaling, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬8件: 6, 70, 72, 127, 168, 193, 206, 226 💬
25 PBFT02 1件: PBFT02---1件: 127 💬
26 Phenothiazine 1件: Phenothiazine1件: Phenothiazine 💬 --1件: 127 💬
27 Pittsburgh Compound B 2件: C-11 PIB; Pittsburgh compound B---3件: 6, 17, 127 💬
28 Rotigotine 3件: Rotigotina; Rotigotine; Rotigotine hydrochloride1件: Rotigotine 💬 1件: DRD2 💬 10件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 6, 67, 127 💬
29 THK-5351 1件: THK-5351---5件: 5, 6, 7, 17, 127 💬
30 Tolcapone 2件: Tolcapon; Tolcapone1件: Tolcapone 💬 1件: COMT 💬 3件: Dopaminergic synapse, Steroid hormone biosynthesis, Tyrosine metabolism 💬3件: 6, 28, 127 💬
31 Valproic acid 3件: Valproate; Valproate sodium; Valproic acid3件: Divalproex sodium ,
Valproic acid ,
Valproate sodium 💬 		7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
E4.1.1.15,
E4.1.1.15 💬 		16件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬13件: 2, 3, 5, 6, 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
32 Verdiperstat 1件: Verdiperstat1件: Verdiperstat 💬 1件: MPO 💬 5件: Acute myeloid leukemia, Drug metabolism - other enzymes, Neutrophil extracellular trap formation, Phagosome, Transcriptional misregulation in cancer 💬2件: 17, 127 💬
33 Vortioxetine 1件: Vortioxetine2件: Vortioxetine ,
Vortioxetine hydrobromide 💬 		7件: HTR1,
HTR3,
HTR3,
HTR3,
HTR3,
HTR3,
SLC6A4 💬 		6件: Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 6, 127 💬