8. Huntington disease Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 296 / Drugs : 245 - (DrugBank : 63) / Drug target genes : 89 - Drug target pathways : 165
Huntington disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 8 | Huntington disease | - |
| 6 | Parkinson disease | 64.162 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 53.890 |
| 2 | Amyotrophic lateral sclerosis | 53.019 |
| 46 | Malignant rheumatoid arthritis | 48.417 |
| 206 | Fragile X syndrome | 44.316 |
| 97 | Ulcerative colitis | 43.315 |
| 140 | Dorabe syndrome | 35.083 |
| 17 | Multiple system atrophy | 34.119 |
| 156 | Rett syndrome | 33.733 |
| 144 | Lennox-Gastaut syndrome | 33.328 |
| 96 | Crohn disease | 33.306 |
| 5 | Progressive supranuclear palsy | 30.643 |
| 21 | Mitochondrial disease | 29.787 |
| 18 | Spinocerebellar degeneration | 27.657 |
| 193 | Prader-Willi syndrome | 25.929 |
| 70 | Spinal stenosis | 24.188 |
| 3 | Spinal muscular atrophy | 22.881 |
| 145 | West syndrome | 22.095 |
| 22 | Moyamoya disease | 18.520 |
| 205 | Fragile X syndrome related disease | 18.480 |
| 34 | Neurofibromatosis | 17.365 |
| 201 | Angelman syndrome | 16.995 |
| 152 | PCDH19-related syndrome | 16.000 |
| 113 | Muscular dystrophy | 15.959 |
| 298 | Hereditary pancreatitis | 15.723 |
| 84 | Sarcoidosis | 15.707 |
| 231 | Alpha-1-antitrypsin deficiency | 14.700 |
| 36 | Epidermolysis bullosa | 14.138 |
| 203 | 22q11.2 deletion syndrome | 14.000 |
| 158 | Tuberous sclerosis | 13.469 |
| 272 | Fibrodysplasia ossificans progressiva | 12.306 |
| 98 | Eosinophilic gastro-intestinal disorder | 12.195 |
| 127 | Frontotemporal lobar degeneration | 10.221 |
| 155 | Acquired aphasia with convulsive disorder | 10.194 |
| 86 | Pulmonary arterial hypertension | 10.139 |
| 75 | Cushing disease | 9.677 |
| 296 | Biliary atresia | 9.514 |
| 299 | Cystic fibrosis | 7.937 |
| 78 | Hypopituitarism | 7.758 |
| 4 | Primary lateral sclerosis | 6.975 |
| 85 | Idiopathic interstitial pneumonia | 6.429 |
| 226 | Interstitial cystitis with Hunners ulcer | 6.286 |
| 107 | Juvenile idiopathic arthritis | 5.474 |
| 118 | Myelomeningocele | 4.607 |
| 51 | Scleroderma | 4.314 |
| 49 | Systemic lupus erythematosus | 4.300 |
| 28 | Systemic amyloidosis | 4.176 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 4.168 |
| 169 | Menkes disease | 4.143 |
| 170 | Occipital horn syndrome | 4.143 |
| 215 | Tetralogy of Fallot | 3.979 |
| 254 | Porphyria | 3.810 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 265 | Lipodystrophy | 2.989 |
| 168 | Ehlers-Danlos syndrome | 2.910 |
| 179 | Williams syndrome | 2.910 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 2.816 |
| 271 | Ankylosing spondylitis | 2.728 |
| 1 | Spinal and bulbar muscular atrophy | 2.649 |
| 10 | Charcot-Marie-Tooth disease | 2.435 |
| 288 | Autoimmune acquired coagulation factor deficiency | 2.286 |
| 309 | Progressive myoclonus epilepsy | 2.277 |
| 87 | Pulmonary veno-occlusive disease | 2.277 |
| 88 | Chronic thromboembolic pulmonary hypertension | 2.106 |
| 11 | Myasthenia gravis | 2.049 |
| 256 | Muscle glycogenosis | 2.032 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 120 | Hereditary dystonia | 2.000 |
| 210 | Single Ventricle | 1.987 |
| 58 | Hypertrophic cardiomyopathy | 1.968 |
| 162 | Pemphigoid | 1.944 |
| 90 | Retinitis pigmentosa | 1.944 |
| 38 | Stevens-Johnson syndrome | 1.865 |
| 67 | Polycystic kidney disease | 1.765 |
| 114 | Non-dystrophic myotonia syndrome | 1.604 |
| 65 | Primary immunodeficiency | 1.405 |
| 20 | Adrenoleukodystrophy | 1.366 |
| 187 | Kabuki syndrome | 1.349 |
| 171 | Wilson disease | 1.349 |
| 222 | Primary nephrotic syndrome | 1.320 |
| 212 | Tricuspid atresia | 1.192 |
| 63 | Idiopathic thrombocytopenic purpura | 1.171 |
| 89 | Lymphangioleiomyomatosis | 1.168 |
| 246 | Methylmalonic acidemia | 1.087 |
| 57 | Idiopathic dilated cardiomyopathy | 1.071 |
| 7 | Corticobasal degeneration | 1.071 |
| 91 | Budd-Chiari syndrome | 1.024 |
| 202 | Smith-Magenis syndrome | 1.024 |
| 71 | Idiopathic osteonecrosis of the femoral head | 1.024 |
| 324 | Methylglutaconic aciduria | 1.000 |